DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sim and EPAS1

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	XP_011531000.1	Gene:	EPAS1 / 2034	HGNCID:	3374	Length:	883	Species:	Homo sapiens

Alignment Length:	673	Identity:	184/673 - (27%)
Similarity:	303/673 - (45%)	Gaps:	156/673 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            ||||::|||.||.||...|.|||..||||.:::|.|||||::||..|:|:..::......|....
Human    29 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESE 93

  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYD 155
            :.|.|      ::.:..|:.|:|||.||..||.::::||..|..:||:||||||:|||::.|..|
Human    94 AEADQ------QMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCD 152

  Fly   156 QDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK-- 218
            .:|:...|||..              ||..|          :.|..:..|:.||:||||.:..
Human   153 HEEIRENLSLKN--------------GSGFG----------KKSKDMSTERDFFMRMKCTVTNRG 193

  Fly   219 RNAGLTTSGFKVIHCSGYLKARIY---PDRGDGQG---SLIQNLGLVAVGHSLPSSAITEIKLHQ 277
            |...|.::.:||:||:|.:|  :|   |......|   .|:..|.::......||.  .:|.|..
Human   194 RTVNLKSATWKVLHCTGQVK--VYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSH--MDIPLDS 254

  Fly   278 NMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKY 342
            ..|:.|..:|||..:.|.|:::|.||.|::|:.::.|::.||.|...|..|||.|..||||.:..
Human   255 KTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQ 319

  Fly   343 YRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAA 407
            ||.|.|.||:||:::..|:::|.|:.:...|:.|||||||.|..|:|.:..||     |.:....
Human   320 YRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQT-----ESLFKPH 379

  Fly   408 QAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSA 472
            ..|..:....:.:.|.:.::..:...::.:    |::...:.|             ||....:|
Human   380 LMAMNSIFDSSGKGAVSEKSNFLFTKLKEE----PEELAQLAP-------------TPGDAIIS- 426

  Fly   473 SPKLD---PYFEPELPLQPAVTPVPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQL 534
               ||   ..||.......|:  :||:...::...:::         .|.::||:.    ::|
Human   427 ---LDFGNQNFEESSAYGKAI--LPPSQPWATELRSHS---------TQSEAGSLP----AFT-- 471

  Fly   535 YPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDA 599
                    |..:::.|..|.|:....||.|..:|         |:.     ||.:     .|.|.
Human   472 --------VPQAAAPGSTTPSATSSSSSCSTPNS---------PED-----YYTS-----LDNDL 509

  Fly   600 TVDVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQTTYSDL------------SHN 652
            .::|...:.          :..:|::.|.||            ||.:::|            ..:
Human   510 KIEVIEKLF----------AMDTEAKDQCST------------QTDFNELDLETLAPYIPMDGED 552

  Fly   653 FELS-------YFSDNSSQQHQH 668
            |:||       ..::|.....||
Human   553 FQLSPICPEERLLAENPQSTPQH 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	29/51 (57%)
		PAS	102..215	CDD:279347	39/112 (35%)
		PAS	102..163	CDD:214512	26/60 (43%)
		PAS	278..376	CDD:238075	37/97 (38%)
		PAS_3	291..377	CDD:285623	32/85 (38%)
EPAS1	XP_011531000.1	HLH	25..81	CDD:238036	29/51 (57%)
		PAS	99..160	CDD:214512	26/60 (43%)
		PAS	254..353	CDD:238075	37/98 (38%)
		PAS_3	267..354	CDD:285623	32/86 (37%)
		HIF-1	530..562	CDD:288296	7/43 (16%)
		HIF-1a_CTAD	846..882	CDD:285931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810