DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sim and Npas1

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_032744.1	Gene:	Npas1 / 18142	MGIID:	109205	Length:	594	Species:	Mus musculus

Alignment Length:	485	Identity:	182/485 - (37%)
Similarity:	266/485 - (54%)	Gaps:	52/485 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVF-----PDGL- 84
            ||||:||||.||.|||.||.|||||||||.||:|||||||::||:.:||::|:..     |.||
Mouse    47 KEKSRNAARWRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLR 111

  Fly    85 --GEAWGSSPAMQRG--ATIKE-----LGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQV 140
              |...|.:|. :||  |.:.|     ||.|:||:||||:|.:..:||.:|||||.|::||||||
Mouse   112 AVGPPAGLAPG-RRGPVALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQV 175

  Fly   141 ELTGNSIFEYIHNYDQDEMNAILSLH---------PHINQHPLAQTHTPIGSPNGVQHPSAYDHD 196
            ||||:|:|:|||..|..|:...|.|.         |.::....:.:.:.:.:|.....|:
Mouse   176 ELTGSSVFDYIHPGDHSEVLEQLGLRAASIGPPTPPSVSSSSSSSSSSLVDTPEIEASPT----- 235

  Fly   197 RGSHTIEI-EKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVA 260
            ..|..... |::||:|||..|.||...:..||:||||.:|.|:||.              |||||
Mouse   236 EASPAFRAQERSFFVRMKSTLTKRGLNVKASGYKVIHVTGRLRARA--------------LGLVA 286

  Fly   261 VGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAM 325
            :||:||.:.:.|:.||.:|.:||..|.:.::..::|||......|.:|:.::.||::|..|...:
Mouse   287 LGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDMGPSELVGRSCYQFVHGQDATRI 351

  Fly   326 RCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVL 390
            |.||..||.||||.|.|||:|.:.||:||:||.||:..|.:|:.|..::.|::|||..|.....|
Mouse   352 RQSHLDLLDKGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKSTGEHHVLWVSHVLSNAEGSQTPL 416

  Fly   391 NEIQTGVV--KREPISPAAQAAQAAQAAQAAQAAQAAQAAH---VAQAVQAQVVVVPQQSVVVQP 450
            :..|...:  :.||..|..:..:........||..|.|...   .|:..:.:|...|:::...:.
Mouse   417 DAFQLPAIVSQEEPSRPGPEPTEEEPPVDGKQAVPADQDKDKDPQARGKRIKVEASPKEARGSED 481

  Fly   451 QCAGATGQPVGPGTP--VSLALSASPKLDP 478
            ........|..|..|  .|:..:.:.|.||
Mouse   482 SGEEELSDPPAPPRPEFTSVIRAGALKHDP 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	37/51 (73%)
		PAS	102..215	CDD:279347	48/127 (38%)
		PAS	102..163	CDD:214512	36/65 (55%)
		PAS	278..376	CDD:238075	38/97 (39%)
		PAS_3	291..377	CDD:285623	34/85 (40%)
Npas1	NP_032744.1	bHLH-PAS_NPAS1_PASD5	43..116	CDD:381574	42/68 (62%)
		PAS	141..198	CDD:214512	33/56 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..237		3/35 (9%)
		PAS_3	316..387	CDD:369881	30/70 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..498		13/70 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840