DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sim and hif-1

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001023891.2	Gene:	hif-1 / 180359	WormBaseID:	WBGene00001851	Length:	721	Species:	Caenorhabditis elegans

Alignment Length:	687	Identity:	150/687 - (21%)
Similarity:	251/687 - (36%)	Gaps:	207/687 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPL-PAAITSQLDKASVIRLTTSYLKMRQ----VFPDGL- 84
            :|.|::|||.||.||:..|.:|...:|: .....:.||:.:::|:..:..::|:    |..:.|
Worm    13 RETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLENNLD 77

  Fly    85 ----GEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGN 145
                .|.|...       ||.|       .||||:.:|..|..|:|::|:.:::|||:|.:|||.
Worm    78 NEITNEVWTED-------TIAE-------CLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLTGR 128

  Fly   146 SIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFL 210
            ::.:::|..|.||.:....:           .|.|                ||..|........|
Worm   129 ALRDFLHPSDYDEFDKQSKM-----------LHKP----------------RGEDTDTTGINMVL 166

  Fly   211 RMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPD---------RGDGQGSLIQNLGLVAVGHSLP 266
            |||.|::.|...|.            ||:.:|..         ...|..|.:|.:.:.|...:..
Worm   167 RMKTVISPRGRCLN------------LKSALYKSVSFLVHSKVSTGGHVSFMQGITIPAGQGTTN 219

  Fly   267 SSAITEIKLHQN---MFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCS 328
            ::|....|..::   .|..|...||::.|...:.:.:...|.:.|:..:.|:.:|.||:|.:..|
Worm   220 ANASAMTKYTESPMGAFTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKS 284

  Fly   329 HQILLYKGQVTTKYYRFLTKGGGWVWVQSYA-TLVHNSRSSREVFIVSVNYVLSEREVKDLVLNE 392
            .:.|..||.:.|.|||.:.......|:|:.| |:.|.::..:..:::.|:|||
Worm   285 MKELFAKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVL------------ 337

  Fly   393 IQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATG 457
               |:          |.|:.:... ...:..|.....:.:.|......:.:|..:|  :|...|
Worm   338 ---GI----------QGAEESLVV-CTDSMPAGMQVDIKKEVDDTRDYIGRQPEIV--ECVDFT- 385

  Fly   458 QPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPV----PPTNNSSSSSNNNNGVWHHHHVQQ- 517
                                |..|||.|....:.||    .|...:...:..|:    :..|.|
Worm   386 --------------------PLIEPEDPFDTVIEPVVGGEEPVKQADMGARKNS----YDDVLQW 426

  Fly   518 --QQQSGS------MDHDSLSYTQLYPPLN--------DLVVSSS-----SSVGGGTASSAG--- 558
              :.|..|      ...|....|:   |.|        |.:.|||     .:..|..|.|.|
Worm   427 LFRDQPSSPPPARYRSADRFRTTE---PSNFGSALASPDFMDSSSRTSRPKTSYGRRAQSQGSRT 488

  Fly   559 -GGSSASASSS------------GVYSTEMQYPDT---TTGNLYYNNNNHYYYDYDATVDVATSM 607
             |.||.|||::            |:....:..|.:   .:|.:.|.:              |.||
Worm   489 TGSSSTSASATLPHSANYSPLAEGISQCGLNSPPSCSIKSGQVVYGD--------------ARSM 539

  Fly   608 IRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQT 644
            .|       ||..|..|.|         .:..|||.|
Worm   540 GR-------SCDPSDSSRR---------FSALSPSDT 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	15/52 (29%)
		PAS	102..215	CDD:279347	30/112 (27%)
		PAS	102..163	CDD:214512	21/60 (35%)
		PAS	278..376	CDD:238075	25/101 (25%)
		PAS_3	291..377	CDD:285623	21/86 (24%)
hif-1	NP_001023891.2	HLH	10..66	CDD:238036	15/52 (29%)
		PAS	94..>145	CDD:238075	20/50 (40%)
		PAS	233..>312	CDD:238075	21/78 (27%)
		PAS_11	236..338	CDD:291273	29/116 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I7753
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm14250
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910