DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sim and hlh-34

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_506391.2	Gene:	hlh-34 / 179860	WormBaseID:	WBGene00011327	Length:	322	Species:	Caenorhabditis elegans

Alignment Length:	364	Identity:	101/364 - (27%)
Similarity:	169/364 - (46%)	Gaps:	60/364 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEK-SKNAARTRREKENTEFCELAKLLPLPAAITSQ-LDKASVIRLTTSYLKMRQVFPDGLGEAW 88
            |:| ||:.|:.||:.||.||.:||..|||..||:.| :||.:::||.|:|:|:..:|  |..:..
Worm     9 KQKPSKSQAQQRRQMENYEFSQLANELPLARAISGQHIDKTTMVRLATAYIKLHNIF--GQSQRA 71

  Fly    89 GSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHN 153
            .||.....|:......:| |..||||..::...|.::|||||.|::|||||||:|||::.:|||.
Worm    72 YSSADYYYGSDSLWTNNH-LDLLDGFFVILDRRGDVLYISETISIYLGLSQVEMTGNAMVDYIHE 135

  Fly   154 YDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK 218
            .|.:..|:.|: :..:|...:..                                 :|:|..|.|
Worm   136 QDINCFNSALN-YCDLNWPQMCN---------------------------------VRVKSSLTK 166

  Fly   219 R---NAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMF 280
            |   :|...:.|:||:.    |:..:.|:         .|..::|. :.:|:..::.:.:..|.|
Worm   167 RANKDAVRASPGYKVLR----LEITMGPN---------TNTRMIAC-YPMPTPVLSTVTIPSNSF 217

  Fly   281 MFRAKLDMKLIFFDARVSQLTG---YEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKY 342
            :....:|:.:.|.|.:..||..   |...::...:||..|..:|...:...|..:...|...|.|
Worm   218 VIITSIDLHITFADEKAHQLLNNPFYPDSNIKGMSLYSLIDISDSEVISKMHFDIFNLGAYKTPY 282

  Fly   343 YRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLS 381
            ||.:.......:........|.|.||:: |..|:.:|.|
Worm   283 YRMILNQTSETFYVESNIFRHTSISSKQ-FNDSITFVSS 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	26/53 (49%)
		PAS	102..215	CDD:279347	32/112 (29%)
		PAS	102..163	CDD:214512	28/60 (47%)
		PAS	278..376	CDD:238075	23/100 (23%)
		PAS_3	291..377	CDD:285623	21/88 (24%)
hlh-34	NP_506391.2	HLH	6..67	CDD:238036	27/59 (46%)
		PAS	93..>145	CDD:238075	26/51 (51%)
		PAS	214..305	CDD:238075	19/90 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I8139
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I3384
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm14175
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900