Protein Alignment sim and hlh-34

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_506391.2
• Gene: hlh-34 / 179860
• WormBaseID: WBGene00011327
• Length: 322
• Species: Caenorhabditis elegans
• Alignment Length: 364
• Identity: 101/364 - (27%)
• Similarity: 169/364 - (46%)
• Gaps: 60/364 - (16%)

  Fly    26 KEK-SKNAARTRREKENTEFCELAKLLPLPAAITSQ-LDKASVIRLTTSYLKMRQVFPDGLGEAW 88
            |:| ||:.|:.||:.||.||.:||..|||..||:.| :||.:::||.|:|:|:..:|  |..:..
 Worm     9 KQKPSKSQAQQRRQMENYEFSQLANELPLARAISGQHIDKTTMVRLATAYIKLHNIF--GQSQRA 71

  Fly    89 GSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHN 153
            .||.....|:......:| |..||||..::...|.::|||||.|::|||||||:|||::.:|||.
 Worm    72 YSSADYYYGSDSLWTNNH-LDLLDGFFVILDRRGDVLYISETISIYLGLSQVEMTGNAMVDYIHE 135

  Fly   154 YDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK 218
            .|.:..|:.|: :..:|...:..                                 :|:|..|.|
 Worm   136 QDINCFNSALN-YCDLNWPQMCN---------------------------------VRVKSSLTK 166

  Fly   219 R---NAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMF 280
            |   :|...:.|:||:.    |:..:.|:         .|..::|. :.:|:..::.:.:..|.|
 Worm   167 RANKDAVRASPGYKVLR----LEITMGPN---------TNTRMIAC-YPMPTPVLSTVTIPSNSF 217

  Fly   281 MFRAKLDMKLIFFDARVSQLTG---YEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKY 342
            :....:|:.:.|.|.:..||..   |...::...:||..|..:|...:...|..:...|...|.|
 Worm   218 VIITSIDLHITFADEKAHQLLNNPFYPDSNIKGMSLYSLIDISDSEVISKMHFDIFNLGAYKTPY 282

  Fly   343 YRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLS 381
            ||.:.......:........|.|.||:: |..|:.:|.|
 Worm   283 YRMILNQTSETFYVESNIFRHTSISSKQ-FNDSITFVSS 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	28/61 (46%)
		PAS	102..215	CDD:395786	32/112 (29%)
		PAS_3	291..377	CDD:430001	21/88 (24%)
hlh-34	NP_506391.2	bHLH_PAS	10..65	CDD:381397	25/54 (46%)
		PAS	93..>145	CDD:238075	26/51 (51%)
		PAS	214..305	CDD:238075	19/90 (21%)