Protein Alignment sim and cky-1

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001122849.1
• Gene: cky-1 / 179743
• WormBaseID: WBGene00000521
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 707
• Identity: 142/707 - (20%)
• Similarity: 241/707 - (34%)
• Gaps: 215/707 - (30%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLG----- 85
            :..::.|::.||::.|.|..:|..||||...|..:|.:..|:.|...:::..:.....|.
 Worm    78 QRSTRGASKQRRDQINVEIQKLRDLLPLSDLIKDRLFQLQVMSLGCIFIRKHRYQQTVLQPQLQM 142

  Fly    86 -EAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVEL--TGNSI 147
             :...||| |.||..|       .:.|.||:.:|...|||:::|:.||.:||.|..|:  .|:||
 Worm   143 LQMQMSSP-MPRGIDI-------CKALRGFMLMVTRSGKILHVSDNASEYLGHSVEEIMCQGDSI 199

  Fly   148 FEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRM 212
            ::.:...|                |...|.....|.|             |:.|...|:.|..|:
 Worm   200 YDLVDGRD----------------HGAVQAELASGPP-------------GAATFPEERVFICRL 235

  Fly   213 KCV-LAKRNAGLTTSGFKVIH---------------------C-----SGYLKARIYPDRGDGQG 250
            ... .|||.  |....|.:..                     |     |.|.:..|.|:..:|
 Worm   236 NLARTAKRQ--LQYHKFVLFQGRYIQPAEFYQQLNAQNSQPDCDQPVFSAYCQPLINPENAEG-- 296

  Fly   251 SLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQ 315
                    ::.|::             ::|..:..||||....|...||..|:..:.|...:.|.
 Worm   297 --------MSTGNT-------------HVFSTQHYLDMKFKEADTMASQHLGFSKEQLKGMSWYG 340

  Fly   316 YIHAADIMAMRCSHQILLY--KGQVTTKYYRFLTKGGGWVWVQSYATLVHNS------RSSREVF 372
            .||...:..:...|::|..  :|.|.. ..|.....|.|:|:.:..::..|:      :..|.|
 Worm   341 MIHPNHVPEIAHKHRLLCQEKEGSVLA-LIRLQAANGEWIWLHTVFSIRPNNELNSDGKRLRHV- 403

  Fly   373 IVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQ 437
            |...:..|::.|...|..|   :.:.......|...:.|.:......|...:.|.....:    |
 Worm   404 IHCFHQKLTDLEAATLQAN---SWIYSMRHTYPTVFSCQDSPPPSEEQQPSSPQTPPFTE----Q 461

  Fly   438 VVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLD-PYFEPELPLQPAVTPVP---PTNN 498
            ..::.:|..::        |..:.||         .|.|| ...:.|:|::|..|.:|   |.::
 Worm   462 PPMLVEQKPLI--------GAGIAPG---------FPSLDYNQIKVEIPMRPINTQIPLFTPESS 509

  Fly   499 S-SSSSNNNNGVWHHHHVQQQQQSGSMD--HDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGG 560
            | .||::.:..:..||:      :..:|  .|.|....:.|.|.|.|
 Worm   510 SPESSASLHTSLLPHHN------AFPLDILEDILPSNDVLPELKDEV------------------ 550

  Fly   561 SSASASSSGVYSTEMQYPDTTTGNLYYNNNN--HYYYDYDATVDVATSMIRPFSANSNSCSSSSE 623
                   ..:.....|.|.|:..:.:.:|.|  |.:           ||...|.
 Worm   551 -------DEILRQVEQSPATSPAHSFPSNVNFGHRH-----------SMPNAFD----------- 586

  Fly   624 SERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQHLMEQQH 680
                    :|.:.....|              :.|..|.:.||||..||||..:..|
 Worm   587 --------SAELYKYLGP--------------ALFDGNFAMQHQHHLQQQHQSQPNH 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	15/65 (23%)
		PAS	102..215	CDD:395786	27/114 (24%)
		PAS_3	291..377	CDD:430001	20/93 (22%)
cky-1	NP_001122849.1	bHLH-PAS_NPAS4_PASD10	78..134	CDD:381540	14/55 (25%)
		PAS	161..>234	CDD:238075	26/101 (26%)
		PAS_11	302..416	CDD:464214	26/128 (20%)