Protein Alignment sim and aha-1

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001251327.1
• Gene: aha-1 / 172889
• WormBaseID: WBGene00000095
• Length: 453
• Species: Caenorhabditis elegans
• Alignment Length: 465
• Identity: 100/465 - (21%)
• Similarity: 174/465 - (37%)
• Gaps: 127/465 - (27%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            :|......|.||.|......|||:::|..|::..:.||.:::|:..|::|       |:
 Worm    46 RENHSEIERRRRNKMTHYINELAEMVPQCASLGRKPDKLTILRMAVSHMK-------GI------ 97

  Fly    91 SPAMQRGATI-------------KELGSHLLQTLDGFIFVV-APDGKIMYISETASVHLGLSQVE 141
                 ||.|.             :||...:|:..:||:||| ...||::|::::.:..|.|.|.:
 Worm    98 -----RGHTAQDETSYKPSFLTDQELKHLILEAANGFLFVVCCQTGKVLYVADSITPVLNLKQED 157

  Fly   142 LTGNSIFEYIHNYDQDE-----------MNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDH 195
            ....::.|.||..|||:           :|.:|.|.....:...|.|...:....|
 Worm   158 WLQRNLNELIHPDDQDKIRDQLCGSEVSVNKVLDLKSGSVKREGASTRVHMSCRRG--------- 213

  Fly   196 DRGSHTIEIEKTFFLRMKCVLAK------------RNAGLTTSGFKVIHCSGYLKARIYPDRGDG 248
                        |..||:....:            ::||   ..:.|:||:||:|..  |.:|..
 Worm   214 ------------FICRMRVGALEPLHRLRNRRPLFQHAG---QNYVVMHCTGYIKNA--PPQGIN 261

  Fly   249 QGSLIQNLGLVAVGH-SLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKT 312
            ..:   :..|||:.. .:.|..:.......|.|..|...|.|:.|.|||||.|.|.....||.:.
 Worm   262 APA---SSCLVAIARLQVASMPVCADPTSTNQFSVRVSEDGKMTFIDARVSDLIGLSSDQLIGRY 323

  Fly   313 LYQYIHAADIMAMRCSHQILL--------YKGQVTTKY-------YRFLTKGGGWVWVQSYATLV 362
            .:...|.||...::.|...||        .:.:.:|.|       |:|:
 Worm   324 WWNLAHPADEKTLQDSFVALLSDQPMRINIRVRTSTDYIPCTVSAYKFM---------------- 372

  Fly   363 HNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQA 427
             |..|.:..::|:.:.:..:.::.:.|          ..|..|..||::..:...|..|....|:
 Worm   373 -NPYSEQFEYVVATHQIAPQEDINNWV----------TAPTVPQPQASEFGELGGAPSAVDYGQS 426

  Fly   428 AHVAQAVQAQ 437
            :......:||
 Worm   427 SSGGWRPEAQ 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	16/59 (27%)
		PAS	102..215	CDD:395786	29/124 (23%)
		PAS_3	291..377	CDD:430001	23/100 (23%)
aha-1	NP_001251327.1	bHLH-PAS_ARNT	41..105	CDD:381517	19/76 (25%)
		PAS	120..179	CDD:214512	18/58 (31%)
		PAS_11	288..393	CDD:464214	28/121 (23%)