DRSC/TRiP Functional Genomics Resources

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Protein Alignment sim and Hif1a

DIOPT Version :10

Sequence 1:NP_524340.2 Gene:sim / 41612 FlyBaseID:FBgn0004666 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_001300848.1 Gene:Hif1a / 15251 MGIID:106918 Length:837 Species:Mus musculus


Alignment Length:731 Identity:197/731 - (26%)
Similarity:320/731 - (43%) Gaps:178/731 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            ||||::|||:||.||:..|.|||..||||..::|.||||||:|||.|||::|::...|   ...|
Mouse    20 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG---GLDS 81

  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYD 155
            ...|:     .::....|:.||||:.|:..||.::|||:..:.::||:|.||||:|:|::.|..|
Mouse    82 EDEMK-----AQMDCFYLKALDGFVMVLTDDGDMVYISDNVNKYMGLTQFELTGHSVFDFTHPCD 141

  Fly   156 QDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK-- 218
            .:||..:|             ||.     ||..        |....:..:::|||||||.|..  
Mouse   142 HEEMREML-------------THR-----NGPV--------RKGKELNTQRSFFLRMKCTLTSRG 180

  Fly   219 RNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLG--------LVAVGHSLPSSAITEIKL 275
            |...:.::.:||:||:|::  .:| |....|    ...|        ||.:...:|..:..||.|
Mouse   181 RTMNIKSATWKVLHCTGHI--HVY-DTNSNQ----PQCGYKKPPMTCLVLICEPIPHPSNIEIPL 238

  Fly   276 HQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTT 340
            ....|:.|..||||..:.|.|:::|.||||::|:.:::|:|.||.|...:..:|..:..||||||
Mouse   239 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTT 303

  Fly   341 KYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISP 405
            ..||.|.|.||:|||::.||:::|:::|:...||.||||:|.....||:.:..||..|.:...|.
Mouse   304 GQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTESVLKPVESS 368

  Fly   406 AAQAAQAAQAAQAAQA-----------------AQAAQAAHVA--------QAVQAQVVVVPQQS 445
            ..:..|.....::...                 |.||....::        :....|:..||..:
Mouse   369 DMKMTQLFTKVESEDTSCLFDKLKKEPDALTLLAPAAGDTIISLDFGSDDTETEDQQLEDVPLYN 433

  Fly   446 VVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNNNGVW 510
            .|:.|    ::.:.:.    ::||:|             ||..:.||.|..:::..:.|....: 
Mouse   434 DVMFP----SSNEKLN----INLAMS-------------PLPSSETPKPLRSSADPALNQEVAL- 476

  Fly   511 HHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYSTEM 575
                    :...|.:...||:|.  |.:.|...|.|.            ||:..:|...:....:
Mouse   477 --------KLESSPESLGLSFTM--PQIQDQPASPSD------------GSTRQSSPERLLQENV 519

  Fly   576 QYPDTTTGNLYYNNNNHYYYDYDATV----------------------------DVATSMIRPF- 611
            ..|:.:..    |:.:.|.:|.|:.:                            |:...|:.|: 
Mouse   520 NTPNFSQP----NSPSEYCFDVDSDMVNVFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYI 580

  Fly   612 ---------------SANSNSCSSSSES------ERQLS----TGNASIVNETSPSQTTYSDLSH 651
                           ...|||.|..|.|      :.||.    |..|:....|..|:|...|...
Mouse   581 PMDDDFQLRSFDQLSPLESNSPSPPSMSTVTGFQQTQLQKPTITATATTTATTDESKTETKDNKE 645

  Fly   652 NFELSYFSDNSSQQHQ 667
            :.::...|.:|:|..|
Mouse   646 DIKILIASPSSTQVPQ 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simNP_524340.2 bHLH-PAS_dSIM_like 25..86 CDD:381583 34/59 (58%)
PAS 102..215 CDD:395786 36/112 (32%)
PAS_3 291..377 CDD:430001 35/85 (41%)
Hif1aNP_001300848.1 bHLH-PAS_HIF1a_PASD8 14..84 CDD:381570 35/66 (53%)
DNA-binding. /evidence=ECO:0000269|PubMed:26245371 22..31 5/8 (63%)
PAS 94..149 CDD:214512 24/54 (44%)
Required for heterodimer formation with ARNT. /evidence=ECO:0000269|PubMed:26245371 171..192 6/20 (30%)
PAS_3 255..340 CDD:430001 35/84 (42%)
N-terminal VHL recognition site 381..418 3/36 (8%)
ODD 402..614 42/259 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..512 6/30 (20%)
NTAD 545..589 3/43 (7%)
HIF-1 565..594 CDD:463274 3/28 (11%)
C-terminal VHL recognition site 570..586 3/15 (20%)
ID 590..796 18/72 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..685 18/68 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..735
Nuclear localization signal. /evidence=ECO:0000255 729..732
CTAD 797..837
HIF-1a_CTAD 800..836 CDD:430212
Blue background indicates that the domain is not in the aligned region.

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