Protein Alignment sim and Arnt2

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_031514.3
• Gene: Arnt2 / 11864
• MGIID: 107188
• Length: 712
• Species: Mus musculus
• Alignment Length: 713
• Identity: 160/713 - (22%)
• Similarity: 270/713 - (37%)
• Gaps: 167/713 - (23%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLK-MRQVFPDGLGEAWG 89
            :|......|.||.|......||:.::|..:|:..:.||.:::|:..|::| ||     |.|....
Mouse    65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMR-----GTGNKST 124

  Fly    90 SSPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFEYIHN 153
            .........|.:||...:|:..|||:||||.: |:::|:|::.:..|...|.|..|::::|.:|.
Mouse   125 DGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHP 189

  Fly   154 YDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKC---- 214
            .|.:::...|....:.....:....|......|.|  |:.....||     .::|..||:|
Mouse   190 DDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQ--SSMRMCMGS-----RRSFICRMRCGNAP 247

  Fly   215 ----------VLAKR---NAGLTTSG---FKVIHCSGYLKARIYP---------DRGDGQGSLIQ 254
                      .:.||   ..|....|   :.|:||:||:||  :|         |...||||
Mouse   248 LDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKA--WPPAGMTIPEEDADVGQGS--- 307

  Fly   255 NLGLVAVGH-SLPSSAI----------TEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDL 308
            ...|||:|. .:.||.:          ||       |:.|...|..:.|.|.|...:.||:||||
Mouse   308 KYCLVAIGRLQVTSSPVCMDMSGMSVPTE-------FLSRHNSDGIITFVDPRCISVIGYQPQDL 365

  Fly   309 IEKTLYQYIHAADIMAMRCS-HQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVF 372
            :.|.:.::.|..|...:|.| .|::..||||.:..|||.||...|:.:::.:....|..|....:
Mouse   366 LGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWLLIRTSSFTFQNPYSDEIEY 430

  Fly   373 IVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQ 437
            ::..|     ..||.|...:.:..|.:|:.:| :...:|.......|...:|.::...|.|:.:|
Mouse   431 VICTN-----TNVKQLQQQQAELEVHQRDGLS-SYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQ 489

  Fly   438 ----------VVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTP 492
                      ..:...:..::....|..:.|....|:|.....|..           ....:|..
Mouse   490 ERDPRFAEMFAGISASEKKMMSSASASGSQQIYSQGSPFPAGHSGK-----------AFSSSVVH 543

  Fly   493 VPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSA 557
            ||..|:..|||:....:        .|.|..::...:::|...||.                  .
Mouse   544 VPGVNDIQSSSSTGQNI--------SQISRQLNQGQVAWTGSRPPF------------------P 582

  Fly   558 GGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSS 622
            |..|...:|:.|:.|:                                   .|:.|:.:|.|..|
Mouse   583 GQPSKTQSSAFGIGSS-----------------------------------HPYPADPSSYSPLS 612

  Fly   623 ESERQLSTGNA--SIVNET----------SPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQ 673
            .......:|||  |:.|.|          ...|...|::...::..:....|.:||.|||..|
Mouse   613 SPAASSPSGNAYPSLANRTPGFAESGQSGGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQ 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	17/60 (28%)
		PAS	102..215	CDD:395786	31/127 (24%)
		PAS_3	291..377	CDD:430001	27/86 (31%)
Arnt2	NP_031514.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..73		1/7 (14%)
		bHLH-PAS_ARNT	62..124	CDD:381517	18/63 (29%)
		PAS	137..243	CDD:395786	30/112 (27%)
		PAS_11	336..436	CDD:464214	32/111 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	573..712		28/156 (18%)