DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sim and Arnt2

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_031514.3	Gene:	Arnt2 / 11864	MGIID:	107188	Length:	712	Species:	Mus musculus

Alignment Length:	713	Identity:	160/713 - (22%)
Similarity:	270/713 - (37%)	Gaps:	167/713 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLK-MRQVFPDGLGEAWG 89
            :|......|.||.|......||:.::|..:|:..:.||.:::|:..|::| ||     |.|....
Mouse    65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMR-----GTGNKST 124

  Fly    90 SSPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFEYIHN 153
            .........|.:||...:|:..|||:||||.: |:::|:|::.:..|...|.|..|::::|.:|.
Mouse   125 DGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHP 189

  Fly   154 YDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKC---- 214
            .|.:::...|....:.....:....|......|.|  |:.....||     .::|..||:|
Mouse   190 DDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQ--SSMRMCMGS-----RRSFICRMRCGNAP 247

  Fly   215 ----------VLAKR---NAGLTTSG---FKVIHCSGYLKARIYP---------DRGDGQGSLIQ 254
                      .:.||   ..|....|   :.|:||:||:||  :|         |...||||
Mouse   248 LDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKA--WPPAGMTIPEEDADVGQGS--- 307

  Fly   255 NLGLVAVGH-SLPSSAI----------TEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDL 308
            ...|||:|. .:.||.:          ||       |:.|...|..:.|.|.|...:.||:||||
Mouse   308 KYCLVAIGRLQVTSSPVCMDMSGMSVPTE-------FLSRHNSDGIITFVDPRCISVIGYQPQDL 365

  Fly   309 IEKTLYQYIHAADIMAMRCS-HQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVF 372
            :.|.:.::.|..|...:|.| .|::..||||.:..|||.||...|:.:::.:....|..|....:
Mouse   366 LGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWLLIRTSSFTFQNPYSDEIEY 430

  Fly   373 IVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQ 437
            ::..|     ..||.|...:.:..|.:|:.:| :...:|.......|...:|.::...|.|:.:|
Mouse   431 VICTN-----TNVKQLQQQQAELEVHQRDGLS-SYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQ 489

  Fly   438 ----------VVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTP 492
                      ..:...:..::....|..:.|....|:|.....|..           ....:|..
Mouse   490 ERDPRFAEMFAGISASEKKMMSSASASGSQQIYSQGSPFPAGHSGK-----------AFSSSVVH 543

  Fly   493 VPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSA 557
            ||..|:..|||:....:        .|.|..::...:::|...||.                  .
Mouse   544 VPGVNDIQSSSSTGQNI--------SQISRQLNQGQVAWTGSRPPF------------------P 582

  Fly   558 GGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSS 622
            |..|...:|:.|:.|:                                   .|:.|:.:|.|..|
Mouse   583 GQPSKTQSSAFGIGSS-----------------------------------HPYPADPSSYSPLS 612

  Fly   623 ESERQLSTGNA--SIVNET----------SPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQ 673
            .......:|||  |:.|.|          ...|...|::...::..:....|.:||.|||..|
Mouse   613 SPAASSPSGNAYPSLANRTPGFAESGQSGGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQ 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	15/52 (29%)
		PAS	102..215	CDD:279347	31/127 (24%)
		PAS	102..163	CDD:214512	20/61 (33%)
		PAS	278..376	CDD:238075	30/98 (31%)
		PAS_3	291..377	CDD:285623	27/86 (31%)
Arnt2	NP_031514.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..73		1/7 (14%)
		bHLH-PAS_ARNT	62..124	CDD:381517	18/63 (29%)
		PAS	137..243	CDD:366402	30/112 (27%)
		PAS_11	336..436	CDD:373151	32/111 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..712		28/156 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47781
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920