DRSC/TRiP Functional Genomics Resources

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Protein Alignment sim and Arnt

DIOPT Version :10

Sequence 1:NP_524340.2 Gene:sim / 41612 FlyBaseID:FBgn0004666 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_001032826.1 Gene:Arnt / 11863 MGIID:88071 Length:791 Species:Mus musculus


Alignment Length:726 Identity:172/726 - (23%)
Similarity:280/726 - (38%) Gaps:141/726 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            :|......|.||.|......||:.::|..:|:..:.||.:::|:..|::|..:    |.|.....
Mouse    91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLR----GTGNTSTD 151

  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFEYIHNY 154
            ........|.:||...:|:..|||:|:|:.: |:::|:|::.:..|...|.|..|:::::.:|..
Mouse   152 GSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPD 216

  Fly   155 DQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSH---------------TIEI 204
            |.|::...||...:.....:....|......|.|  |:.....||.               .:.:
Mouse   217 DVDKLREQLSTSENALTGRVLDLKTGTVKKEGQQ--SSMRMCMGSRRSFICRMRCGTSSVDPVSM 279

  Fly   205 EKTFFLRMKCVLAKRNAGLTTSG---FKVIHCSGYLKARIYPDRG---------DGQGSLIQNLG 257
            .:..|||.:|   :...|....|   |.|:||:||:||  :|..|         .||||   ...
Mouse   280 NRLSFLRNRC---RNGLGSVKEGEPHFVVVHCTGYIKA--WPPAGVSLPDDDPEAGQGS---KFC 336

  Fly   258 LVAVGH----SLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIH 318
            |||:|.    |.|:............|:.|..::....|.|.|.....||:||:|:.|.:.::.|
Mouse   337 LVAIGRLQVTSSPNCTDMSNICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCH 401

  Fly   319 AADIMAMRCS-HQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIV--SVNYVL 380
            ..|...:|.| .|::..||||.:..:||.:|...|:|:::.:....|..|....:|:  :.|...
Mouse   402 PEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWLWMRTSSFTFQNPYSDEIEYIICTNTNVKN 466

  Fly   381 SEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQS 445
            |.:|.:..:.|     .:.|..:.|.|..:......|.....|..|        ..::.:||.:.
Mouse   467 SSQEPRPTLSN-----TIPRSQLGPTANLSLEMGTGQLPSRQQQQQ--------HTELDMVPGRD 518

  Fly   446 VVVQPQCAGATGQPV-GPGTPVSLALSASPKL-----DPYFEPELPLQPAVTPVPPTNNSSSSSN 504
            .:.....:..:.||| ..|:..|..|..|..|     ||.| ||  :.|::|.......|||:. 
Mouse   519 GLASYNHSQVSVQPVASAGSEHSKPLEKSEGLFAQDRDPRF-PE--IYPSITADQSKGISSSTV- 579

  Fly   505 NNNGVWHHHHVQQQQQSGS------MDHDSLSYTQLYPPLNDLVVSSSSSVG------GGTASSA 557
                    ...||....||      ...::...:.|.||:.  :|..|||.|      ...::.|
Mouse   580 --------PATQQLFSQGSSFPPNPRPAENFRNSGLTPPVT--IVQPSSSAGQILAQISRHSNPA 634

  Fly   558 GGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSS 622
            .|.:....|||.......|.|...|                     |.:....|..| |..:|||
Mouse   635 QGSAPTWTSSSRPGFAAQQVPTQAT---------------------AKTRSSQFGVN-NFQTSSS 677

  Fly   623 ESERQL------STGNA---SIVNETS-----PSQTTYSDLSHNFE-----------LSYFSDNS 662
            .|...|      |:|.|   ::.|..|     ..|||....:...|           ..:...:|
Mouse   678 FSAMSLPGAPTASSGTAAYPALPNRGSNFPPETGQTTGQFQARTAEGVGVWPQWQGQQPHHRSSS 742

  Fly   663 SQQHQHQQQQQ 673
            |:||..|.|.|
Mouse   743 SEQHVQQTQAQ 753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simNP_524340.2 bHLH-PAS_dSIM_like 25..86 CDD:381583 15/59 (25%)
PAS 102..215 CDD:395786 29/128 (23%)
PAS_3 291..377 CDD:430001 26/88 (30%)
ArntNP_001032826.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..97 1/5 (20%)
bHLH-PAS_ARNT 86..150 CDD:381517 16/62 (26%)
DNA-binding. /evidence=ECO:0000269|PubMed:26245371, ECO:0000269|PubMed:28602820 88..128 9/36 (25%)
Required for heterodimer formation with EPAS1. /evidence=ECO:0000269|PubMed:26245371 112..264 37/157 (24%)
Required for heterodimer formation with HIF1A. /evidence=ECO:0000269|PubMed:26245371 112..168 13/59 (22%)
PAS 163..269 CDD:395786 26/107 (24%)
Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000269|PubMed:24001774 167..171 1/3 (33%)
PAS_11 362..462 CDD:464214 28/99 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..508 9/55 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..554 8/23 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..667 9/56 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..715 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 730..791 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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