DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sim and sim2

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	XP_031752412.1	Gene:	sim2 / 100492082	XenbaseID:	XB-GENE-1013958	Length:	761	Species:	Xenopus tropicalis

Alignment Length:	663	Identity:	300/663 - (45%)
Similarity:	364/663 - (54%)	Gaps:	173/663 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWG 89
            |||||||||:|||||||.||.|||||||||:||||||||||:|||||||||||.|||||||:|||
Frog     1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPDGLGDAWG 65

  Fly    90 SSPAM-QRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHN 153
            ....| ......||||||||||||||:||||.|||||||||||||||||||||||||||:||||.
Frog    66 HPSRMGPLDNVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHP 130

  Fly   154 YDQDEMNAILS----LHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKC 214
            .|.|||.|:|:    ||||:.|.                             .|||::|||||||
Frog   131 SDHDEMTAVLTAHQPLHPHLLQE-----------------------------YEIERSFFLRMKC 166

  Fly   215 VLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNM 279
            ||||||||||.||:||||||||||.|.|........|..|.:||||||.|||.|||||||||.||
Frog   167 VLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDISLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNM 231

  Fly   280 FMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYR 344
            |||||.||:||||.|:||::|||||||||||||||.::|..|:..:|.||.:||.||||||||||
Frog   232 FMFRASLDLKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDVFHLRYSHHLLLVKGQVTTKYYR 296

  Fly   345 FLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVK-----REPIS 404
            .|:|.|||||||||||:||||||||...||||||||::.|.|:|.|:..|..|.|     |.|::
Frog   297 LLSKNGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLEQVTVSKVPFSCRTPMT 361

  Fly   405 PAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSL- 468
            .:.:|.:                                                     |:.:
Frog   362 TSQEARK-----------------------------------------------------PIKVK 373

  Fly   469 --ALSASPKLDPYFEPELPL--------QPAVTPVPPTNNSSSSSNNNNGVWHHHHVQQQQQSGS 523
              .:.:.|:.:||.:|....        |.......||.|::::               |:||..
Frog   374 SGKVKSKPRANPYPQPYTSFIGDKLDCSQYGSWKGSPTINTATN---------------QEQSNH 423

  Fly   524 MDHDSLSYTQLYP----------PLNDLVVSSSSSVGGGTASSAGGGSSASASSSG--VYSTEMQ 576
            .::..|.||..|.          |::..|:||...|   ..|..|...|:|.....  .:||
Frog   424 SENSELLYTPTYSLPFPYHYGHFPMDSHVLSSKKQV---VPSRYGQPQSSSPCEVARFFFST--- 482

  Fly   577 YPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSP 641
                    |......|::|         |:.:.|.|...|                   :::.|.
Frog   483 --------LQTGGECHWHY---------TNSVVPGSPPKN-------------------IHDQSV 511

  Fly   642 SQTTYSDLSHNFE 654
            :|..: :|:||:|
Frog   512 NQARH-NLAHNYE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	46/51 (90%)
		PAS	102..215	CDD:279347	68/116 (59%)
		PAS	102..163	CDD:214512	53/60 (88%)
		PAS	278..376	CDD:238075	71/97 (73%)
		PAS_3	291..377	CDD:285623	61/85 (72%)
sim2	XP_031752412.1	bHLH-PAS_SIM2	1..74	CDD:381582	59/72 (82%)
		PAS	88..>158	CDD:238075	52/98 (53%)
		PAS_3	243..329	CDD:369881	61/85 (72%)
		SIM_C	359..636	CDD:399545	42/276 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4763
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm49524
Panther	1	1.100	-	-	O	PTHR23043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.100