DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pic and DDB1A

DIOPT Version :9

Sequence 1:	NP_650257.1	Gene:	pic / 41611	FlyBaseID:	FBgn0260962	Length:	1140	Species:	Drosophila melanogaster
Sequence 2:	NP_192451.1	Gene:	DDB1A / 825890	AraportID:	AT4G05420	Length:	1088	Species:	Arabidopsis thaliana

Alignment Length:	1151	Identity:	542/1151 - (47%)
Similarity:	748/1151 - (64%)	Gaps:	77/1151 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SHHYVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRPLKEININGTIAVMRH 66
            |.:|||||.|||:|.....||||||.:||||:|:..::||.|:||:||:|:.::.|.|.||.:..
plant     3 SWNYVVTAHKPTSVTHSCVGNFTSPQELNLIVAKCTRIEIHLLTPQGLQPMLDVPIYGRIATLEL 67

  Fly    67 FRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAIDPKARVI 131
            |||....:|.|||.|.||...:|:  ...:...::|:|.|:|||.:|.|::.|.|..|||..|:|
plant    68 FRPHGEAQDFLFIATERYKFCVLQ--WDPESSELITRAMGDVSDRIGRPTDNGQIGIIDPDCRLI 130

  Fly   132 GMCLYQGLFTIIPMDKDASELKATNLRMDELNVYDVEFLHGCLNPTVIVIHKDS-DGRHVKSHEI 195
            |:.||.|||.:||.|......:|.|:|::||.|.|::||.||..||:.|:::|: |.||||::|:
plant   131 GLHLYDGLFKVIPFDNKGQLKEAFNIRLEELQVLDIKFLFGCAKPTIAVLYQDNKDARHVKTYEV 195

  Fly   196 NLRDKEFMKIAWKQDNVETEATMLIPVPSPIGGVIVIGRESIVYHDGSNYHAVAPLTFRQSTINC 260
            :|:||:|::..|.|::::..|.:|||||.|:.||::||.|:|||...|.:.|: |:  |.|....
plant   196 SLKDKDFVEGPWSQNSLDNGADLLIPVPPPLCGVLIIGEETIVYCSASAFKAI-PI--RPSITKA 257

  Fly   261 YARVSSNGLRYLLGNMDGQLYMLFLGTAETSKGVTVKDIKVEQLGEISIPECITYLDNGFLYIGA 325
            |.||..:|.|||||:..|.:::|.: |.|..|   |..:|:|.|||.||...|:||||..:::|:
plant   258 YGRVDVDGSRYLLGDHAGMIHLLVI-THEKEK---VTGLKIELLGETSIASTISYLDNAVVFVGS 318

  Fly   326 RHGDSQLVRLNSEA-IDGSYVVPVENFTNLAPILDIAVVDLDRQGQGQIITCSGSFKDGSLRIIR 389
            .:||||||:||... ..||||..:|.:.||.||:|..||||:||||||::||||:|||||||::|
plant   319 SYGDSQLVKLNLHPDAKGSYVEVLERYINLGPIVDFCVVDLERQGQGQVVTCSGAFKDGSLRVVR 383

  Fly   390 IGIGIQEHACIDLPGIKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGE-EVEETEIPGFASD 453
            .||||.|.|.::|.|||||||||..:||: ::..||::|:..||||.::.| |:|||||.||.|.
plant   384 NGIGINEQASVELQGIKGMWSLKSSIDEA-FDTFLVVSFISETRILAMNLEDELEETEIEGFLSQ 447

  Fly   454 LQTFLCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQILVAS-ACDIFY 517
            :||..|.:..|:||:||||:|||||||.|:.|..||......|:.|.:.|.:|:|:|: ...:.|
plant   448 VQTLFCHDAVYNQLVQVTSNSVRLVSSTTRELRDEWHAPAGFTVNVATANASQVLLATGGGHLVY 512

  Fly   518 IVIEDGSLREQSRRTLAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLPDLETIYTEKLS 582
            :.|.||.|.|.....|.|||:||||.|:.:....|.|.|||:|||||..|.|||:|..|..|:|.
plant   513 LEIGDGKLTEVQHALLEYEVSCLDINPIGDNPNYSQLAAVGMWTDISVRIFSLPELTLITKEQLG 577

  Fly   583 GEIIPRSILMTTFEGIHYLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGTQPTTLRTFRSLSTTN 647
            |||||||:|:..||||.|||||||||.:..|.||.|||||.|:|||:|||||.|||||.|.|.|:
plant   578 GEIIPRSVLLCAFEGISYLLCALGDGHLLNFQMDTTTGQLKDRKKVSLGTQPITLRTFSSKSATH 642

  Fly   648 VFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNAVILGTIDEIQKLHIR 712
            |||.|||||||||||.||::||||||||:|||..|:.|:|||||:|.:..:.:||||:|||||||
plant   643 VFAASDRPTVIYSSNKKLLYSNVNLKEVSHMCPFNSAAFPDSLAIAREGELTIGTIDDIQKLHIR 707

  Fly   713 TVPLGEGPRRIAYQESSQTFAVSTLRIDVHGRGGAKPLRNSASTQAQNITCSSNFLPKPGGGNST 777
            |:||||..|||.:||.::||.:.:|                                    ||.
plant   708 TIPLGEHARRICHQEQTRTFGICSL------------------------------------GNQ- 735

  Fly   778 AANAEVGQEIDVHNLLVIDQNTFEVLHAHQFVAPETISSLMSAKLGDDPNTYYVVATSLVIPEEP 842
             :|:|   |.::|.:.::|..|||.:..:...:.|...|::|....:|.|.||.|.|:.|:|||.
plant   736 -SNSE---ESEMHFVRLLDDQTFEFMSTYPLDSFEYGCSILSCSFTEDKNVYYCVGTAYVLPEEN 796

  Fly   843 EPKVGRIIIFHYHENKLTQVAETKVDGTCYALVEFNGKVLAGIGSFVRLYEW----TNEKELRME 903
            ||..|||::|...:.:|..:||.:..|..|:|..||||:||.|...::||:|    ...:||:.|
plant   797 EPTKGRILVFIVEDGRLQLIAEKETKGAVYSLNAFNGKLLAAINQKIQLYKWMLRDDGTRELQSE 861

  Fly   904 CNIQNMIAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARDCEPKWMRAVEILDDDTFLG 968
            |.....|.||:::.:||||:|||||:||:||.:|..||...|.|||....||.||||||||.:||
plant   862 CGHHGHILALYVQTRGDFIVVGDLMKSISLLLYKHEEGAIEERARDYNANWMSAVEILDDDIYLG 926

  Fly   969 SETNGNLFVCQKDSAATTDEERQLLPELARFHLGDTVNVFRHGSLVMQ----NVGERTTPINGCV 1029
            :|.|.||...:|:|...|||||..|..:..:|||:.||.||||||||:    .:|:..|     |
plant   927 AENNFNLLTVKKNSEGATDEERGRLEVVGEYHLGEFVNRFRHGSLVMRLPDSEIGQIPT-----V 986

  Fly  1030 LYGTCNGAIGIVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHTYYRNFQINSKVEPSEGFIDGDL 1094
            ::||.||.||::..:||:.|.||..|:..|:|:||.||.:.|..:|:|....:...:..|:||||
plant   987 IFGTVNGVIGVIASLPQEQYTFLEKLQSSLRKVIKGVGGLSHEQWRSFNNEKRTAEARNFLDGDL 1051

  Fly  1095 IESFLDLSRDKMRDAVQGLELTLNGERKSADVEDVIKIVEDLTRMH 1140
            |||||||||:||.|..:.:         :..||::.|.||:|||:|
plant  1052 IESFLDLSRNKMEDISKSM---------NVQVEELCKRVEELTRLH 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pic	NP_650257.1	SFT1	13..1139	CDD:227490	532/1137 (47%)
		MMS1_N	75..542	CDD:287414	221/470 (47%)
		CPSF_A	792..1100	CDD:281209	136/315 (43%)
DDB1A	NP_192451.1	MMS1_N	76..537	CDD:402179	221/470 (47%)
DDB1A	NP_192451.1	CPSF_A	744..1057	CDD:397339	137/317 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	414	1.000	Domainoid score	I125
eggNOG	1	0.900	-	-		E1_KOG1897
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1448
Inparanoid	1	1.050	1000	1.000	Inparanoid score	I42
OMA	1	1.010	-	-		QHG55223
OrthoDB	1	1.010	-	-		D146622at2759
OrthoFinder	1	1.000	-	-		FOG0005098
OrthoInspector	1	1.000	-	-		otm3135
orthoMCL	1	0.900	-	-		OOG6_102651
Panther	1	1.100	-	-	LDO	PTHR10644
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840