DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pic and Sf3b3

DIOPT Version :9

Sequence 1:	NP_650257.1	Gene:	pic / 41611	FlyBaseID:	FBgn0260962	Length:	1140	Species:	Drosophila melanogaster
Sequence 2:	NP_728546.1	Gene:	Sf3b3 / 38093	FlyBaseID:	FBgn0035162	Length:	1227	Species:	Drosophila melanogaster

Alignment Length:	1299	Identity:	279/1299 - (21%)
Similarity:	524/1299 - (40%)	Gaps:	248/1299 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEG----LRPLKEININGTIAVMR 65
            |.:|.||.|.|...:.|||:......::::|...:|  |:.|:.    :..|....|.|.:..:.
  Fly     4 YNLTLQKATGVTHAVHGNFSGGKQQEVLLSRGKSLE--LLRPDSNTGKVHTLLSTEIFGCVRALM 66

  Fly    66 HFRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVG----IPSEGGVIAAIDP 126
            .||.....||.:.:.:....::|||   .|.....:.|.:.......|    :|   |...||||
  Fly    67 AFRLTGGTKDYIVVGSDSGRIVILE---YNPSKNALEKVHQETFGKSGCRRIVP---GQYFAIDP 125

  Fly   127 KAR--VIGMCLYQGLFTIIPMDKDASELKATNLRMDELNV-------YDVEF---LHGCLNPTVI 179
            |.|  :||....|.|..|:..|..|....::.|...:.|.       .||.|   :..||.....
  Fly   126 KGRAVMIGAVEKQKLAYIMNRDTQARLTISSPLEAHKSNTLTYHMVGVDVGFDNPMFACLEIDYE 190

  Fly   180 VIHKDSDG-------RHVKSHEINLRDKEFMKIAWKQDNVETEATMLIPVP----SPIGGVIVIG 233
            ....|..|       :.:..:|::|.....::  ...:.:|..|..|:.||    .| .||::..
  Fly   191 EADMDPSGDAAQRTQQTLTFYELDLGLNHVVR--KYSEPLEEHANFLVSVPGGNDGP-SGVLICS 252

  Fly   234 RESIVYHDGSNYHAV-APLTFRQSTIN---------CYARVSSNGLR-YLLGNMDGQLYMLFLGT 287
            ...:.|.:..:.|.: .|:..|::.::         |.|...:..:. :||....|.::.:   |
  Fly   253 ENYLTYKNLGDQHDIRCPIPRRRNDLDDPERGMIFICSATHRTKSMYFFLLQTEQGDIFKI---T 314

  Fly   288 AETSKGVTVKDIKVEQLGEISIPECITYLDNGFLYIGARHGDS---QLVRLNSEAIDGSY----- 344
            .||...| |.:||::....:.....:..|..|||::.:..|:.   |:..|..:..:..:
  Fly   315 LETDDDV-VSEIKLKYFDTVPPATAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDDEPEFSSAMP 378

  Fly   345 ----------------VVPVENFTNLAPILDIAVVDLDRQGQGQIITCSGSFKDGSLRIIRIGIG 393
                            :|.|:...:.|||:...|.||..:...|:....|.....:||::|.|:.
  Fly   379 LEEGETFFFAPRALKNLVLVDELPSFAPIITSQVADLANEDTPQLYVLCGRGPRSTLRVLRHGLE 443

  Fly   394 IQEHACIDLPG-IKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEEVEETEIPGFASDLQTF 457
            :.|.|..:||| ...:|::|...|:. ::..::::||..|.:|:: ||.|||....||.....|.
  Fly   444 VSEMAVSELPGNPNAVWTVKKRADDE-FDAYIIVSFVNATLVLSI-GETVEEVTDSGFLGTTPTL 506

  Fly   458 LCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQILVA-SACDIFYIVIE 521
            .|:.:..|.|:||..|.:|.:.|..:  |.||:..|.::|...:.|..|:::. |..::.|..::
  Fly   507 CCAALGDDALVQVYPDGIRHIRSDKR--VNEWKAPGKKSITKCAVNQRQVVITLSGRELVYFEMD 569

  Fly   522 -DGSLREQSRRT-LAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLPDLETIYTEKLSGE 584
             .|.|.|.:.|: :..|:.|:.:..:.|.:::|..:|||| .|.:..|||| |.....| ..|.:
  Fly   570 PTGELNEYTERSEMPAEIMCMALGTVPEGEQRSWFLAVGL-ADNTVRILSL-DPNNCLT-PCSMQ 631

  Fly   585 IIP---RSILM--------TTFEGIH---------------YLLCALGDGSMYYFIMDQTTGQLT 623
            .:|   .|:.:        ||..|:.               ||...|.:|.:...::|..:|.|.
  Fly   632 ALPSPAESLCLVEMGHTESTTQGGLDDDAPAQRSGNNKGTIYLNIGLSNGVLLRTVLDPVSGDLA 696

  Fly   624 DKKKVTLGTQPTTLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPD 688
            |.:...||::|..|...:...:..|.|.|.|..:.|...::...:.::.:.:.:....:::...:
  Fly   697 DTRTRYLGSRPVKLFRIKMQGSEAVLAMSSRTWLSYYHQNRFHLTPLSYETLEYASGFSSEQCSE 761

  Fly   689 SLALANKNAVILGTIDEIQKLHIRTV-PLGEGPRRI-----------------AYQESSQTFAVS 735
            .:...:.|.:.:..::::..:..:.. ||...||..                 ||.|.:::....
  Fly   762 GIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRTFVIHPDTGRMLIAETDHNAYTEDTKSARKE 826

  Fly   736 TLRIDVHGRGGAKPLRNSASTQAQNITCSSNFLPKPGGGNSTAANAEVGQEI--DVHN------- 791
            .:         |:.:|::|..:.:.:.             ...|||.:.:.:  ||.:
  Fly   827 QM---------AEEMRSAAGDEERELA-------------REMANAFINEVLPEDVFSSPKAGLG 869

  Fly   792 LLVIDQNTFEVLHAH-QFVAP----ETISSLMSAKLGDDPNTYYVVATSLVIPEEPEPKV---GR 848
            |........:.:|.. .|..|    |.|.|:...|.....:..|.:|..:....:..|::   |.
  Fly   870 LWASQIRCLDAMHGQTMFSVPLTQNEAIMSMAMLKFSIAADGRYYLAVGIAKDLQLNPRISQGGC 934

  Fly   849 IIIFHYHENKLTQVAETKVDGTCY---------------ALVEFNGKVLAGIGSFVRLYEWTNEK 898
            |.|:             |:|.||.               ||..|.|::|||.|..:|:|::..:|
  Fly   935 IDIY-------------KIDPTCSSLEFMHRTDIDEIPGALCGFQGRLLAGCGRMLRIYDFGKKK 986

  Fly   899 ELRMECNIQNM-IAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARDCEPKWMRAVEILD 962
            .|| :|..::: ...:.::|.|..:.|.|:..|:..:::::.|...:..|.|..|:|:.|..:||
  Fly   987 MLR-KCENKHIPYQIVNIQAMGHRVYVSDVQESVFFIRYRRAENQLIIFADDTHPRWVTATTLLD 1050

  Fly   963 DDTFLGSETNGNLFVCQKDSAATTDE------------ERQLL-------PELARFHLGDTVNVF 1008
            .||...::..|||.: |:...:.||:            :|.||       ..:..||:|:.:...
  Fly  1051 YDTIAIADKFGNLSI-QRLPHSVTDDVDEDPTGTKSLWDRGLLSGASQKSENICSFHVGEIIMSL 1114

  Fly  1009 RHGSLVMQNVGERTTPINGCVLYGTCNGAIG-IVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHT 1072
            :..:|:...        :..::|.|.:|.:| .|....::.|||...||..::.....:...:|.
  Fly  1115 QKATLIPGG--------SEALIYATLSGTVGAFVPFTSREDYDFFQHLEMHMRNENPPLCGRDHL 1171

  Fly  1073 YYRNFQINSKVEPSEGFIDGDLIESFLDLSRDKMRDAVQGLELTLNGERKSADVEDVIKIVEDL 1136
            .||     |...|.:..:||||.|.:|.:...|.:.....:..|.|         .:.|.:||:
  Fly  1172 SYR-----SSYYPVKNVLDGDLCEQYLSIEAAKQKSIAGDMFRTPN---------QICKKLEDI 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pic	NP_650257.1	SFT1	13..1139	CDD:227490	275/1291 (21%)
		MMS1_N	75..542	CDD:287414	121/532 (23%)
		CPSF_A	792..1100	CDD:281209	80/351 (23%)
Sf3b3	NP_728546.1	MMS1_N	76..592	CDD:402179	121/532 (23%)
Sf3b3	NP_728546.1	CPSF_A	872..1194	CDD:397339	79/349 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10644
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940