Protein Alignment pic and SF3B3

DIOPT Version :10

• Sequence 1: NP_650257.1
• Gene: pic / 41611
• FlyBaseID: FBgn0260962
• Length: 1140
• Species: Drosophila melanogaster
• Sequence 2: NP_036558.3
• Gene: SF3B3 / 23450
• HGNCID: 10770
• Length: 1217
• Species: Homo sapiens
• Alignment Length: 1271
• Identity: 285/1271 - (22%)
• Similarity: 536/1271 - (42%)
• Gaps: 202/1271 - (15%)

  Fly     5 YVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRP---------LKEININGT 60
            |.:|.|:.|.:...:.|||:......::::|...:|:       |||         |..:.:.|.
Human     4 YNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILEL-------LRPDPNTGKVHTLLTVEVFGV 61

  Fly    61 IAVMRHFRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAID 125
            |..:..||.....||.:.:.:....::|||.:...::...:.:.....|....|..  |...|:|
Human    62 IRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVP--GQFLAVD 124

  Fly   126 PKARVIGMCLYQGLFTIIPMDKDASEL----------KATNLRMDELNVYDVEF---LHGCLNPT 177
            ||.|.:.:...:....:..:::||:..          ||..|....:.| ||.|   :..||...
Human   125 PKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGV-DVGFENPMFACLEMD 188

  Fly   178 VIVIHKDSDGRHVKSHEINLR----DKEFMKIAWK-QDNVETEATMLIPVP----SPIGGVIVIG 233
            ......|..|....:.:..|.    |.....:..| .:.:|.....||.||    .| .||::..
Human   189 YEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGP-SGVLICS 252

  Fly   234 RESIVYHD-GSNYHAVAPLTFRQSTIN---------CYARVSSNGLRYLLGNMD-GQLYMLFLGT 287
            ...|.|.: |.......|:..|::.::         |.|...:..:.:.|...: |.::.:.|.|
Human   253 ENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLET 317

  Fly   288 AETSKGVTVKDIKVEQLGEISIPECITYLDNGFLYIGARHGDSQLVRL-----NSEAIDGSYVVP 347
            .|.    .|.:|:::....:.:...:..|..|||::.:..|:..|.::     :.|..:.|..:|
Human   318 DED----MVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMP 378

  Fly   348 -------------------VENFTNLAPILDIAVVDLDRQGQGQIITCSGSFKDGSLRIIRIGIG 393
                               |:...:|:|||...:.||..:...|:....|.....|||::|.|:.
Human   379 LEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLE 443

  Fly   394 IQEHACIDLPG-IKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEEVEETEIPGFASDLQTF 457
            :.|.|..:||| ...:|:::..: |..::..::::||..|.:|:: ||.|||....||.....|.
Human   444 VSEMAVSELPGNPNAVWTVRRHI-EDEFDAYIIVSFVNATLVLSI-GETVEEVTDSGFLGTTPTL 506

  Fly   458 LCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQILVA-SACDIFYIVIE 521
            .||.:..|.|:||..|.:|.:.:..:  |.||:..|.:||...:.|..|:::| :..::.|..::
Human   507 SCSLLGDDALVQVYPDGIRHIRADKR--VNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMD 569

  Fly   522 -DGSLREQS-RRTLAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLPDLETIYTEKLSGE 584
             .|.|.|.: |:.::.:|.|:.:..:...:::|..:|||| .|.:..|:||...:.:  :.||.:
Human   570 PSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGL-VDNTVRIISLDPSDCL--QPLSMQ 631

  Fly   585 II---PRSILMTTFEGIH--------------YLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGT 632
            .:   |.|:.:....|..              ||...|.:|.:...::|..||.|:|.:...||:
Human   632 ALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGS 696

  Fly   633 QPTTLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNA 697
            :|..|...|......|.|.|.|..:.||...:...:.::.:.:.......::..|:.:...:.|.
Human   697 RPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNT 761

  Fly   698 VILGTIDEIQKLHIRTV-PLGEGPRR-IAYQESSQTFAVSTLRIDVHG----------RGGAKPL 750
            :.:..::::..:..:.. ||...||: :.:.||:....:.|   |.:.          :..|:.:
Human   762 LRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIET---DHNAYTEATKAQRKQQMAEEM 823

  Fly   751 RNSASTQAQNITCS------SNFLPKPGGGNSTAANAEVGQEIDVHNLLVIDQNTFEVLHAHQFV 809
            ..:|....:.:...      :..||:...|...|.|.:....|.|.|  .|..||.:::...|..
Human   824 VEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMN--PIQGNTLDLVQLEQNE 886

  Fly   810 APETISSLMSAKLGDDPNTYYV---VATSLVIPEEPEPKVGRIIIFHYHEN---KLTQVAETKVD 868
            |..:::....:..|:|   :||   ||..|::  .|....|..:..:...|   ||..:.:|.|:
Human   887 AAFSVAVCRFSNTGED---WYVLVGVAKDLIL--NPRSVAGGFVYTYKLVNNGEKLEFLHKTPVE 946

  Fly   869 GTCYALVEFNGKVLAGIGSFVRLYEWTNEKELRMEC---NIQNMIAALFLKAKGDFILVGDLMRS 930
            ....|:..|.|:||.|:|..:|:|:...:|.|| :|   :|.|.|:.  ::..|..::|.|:..|
Human   947 EVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLR-KCENKHIANYISG--IQTIGHRVIVSDVQES 1008

  Fly   931 ITLLQHKQMEGIFVEIARDCEPKWMRAVEILDDDTFLGSETNGNLFVCQKDSAATTDE------- 988
            ...:::|:.|...:..|.|..|:|:....:||.||..|::..||:.|.:. ...|.||
Human  1009 FIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRL-PPNTNDEVDEDPTG 1072

  Fly   989 -----ERQLL-------PELARFHLGDTVNVFRHGSLVMQNVGERTTPING---CVLYGTCNGAI 1038
                 :|.||       ..:..:|:|:||       |.:|    :||.|.|   .::|.|.:|.|
Human  1073 NKALWDRGLLNGASQKAEVIMNYHVGETV-------LSLQ----KTTLIPGGSESLVYTTLSGGI 1126

  Fly  1039 GIVTQIP---QDFYDFLHGLEERLKKIIKSVGKIEHTYYRNFQINSKVEPSEGFIDGDLIESFLD 1100
            ||:  :|   .:.:||...:|..|:.....:...:|..:|::..     |.:..|||||.|.|..
Human  1127 GIL--VPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYF-----PVKNVIDGDLCEQFNS 1184

  Fly  1101 LSRDKMRDAVQGLELTLNGERKSADVEDVIKIVEDL 1136
            :..:|.::..:.|:.|         ..:|.|.:||:
Human  1185 MEPNKQKNVSEELDRT---------PPEVSKKLEDI 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pic	NP_650257.1	MMS1_N	75..542	CDD:463091	116/527 (22%)
		CPSF_A	790..1100	CDD:427182	91/343 (27%)
SF3B3	NP_036558.3	MMS1_N	76..592	CDD:463091	116/527 (22%)
		Interaction with PHF5A, SF3B1 and SF3B5. /evidence=ECO:0000269|PubMed:27720643	105..119		2/15 (13%)
		Interaction with PHF5A, SF3B1 and SF3B5. /evidence=ECO:0000269|PubMed:27720643	145..168		5/22 (23%)
		Interaction with SF3B1 and SF3B5. /evidence=ECO:0000269|PubMed:27720643	193..231		6/37 (16%)
		Interaction with SF3B1 and SF3B5. /evidence=ECO:0000269|PubMed:27720643	786..804		4/20 (20%)
		CPSF_A	863..1182	CDD:427182	92/347 (27%)
		Interaction with SF3B1. /evidence=ECO:0000269|PubMed:27720643	1028..1049		7/20 (35%)
		Interaction with SF3B5. /evidence=ECO:0000269|PubMed:27720643	1100..1123		10/33 (30%)