Protein Alignment pic and ddb-1

DIOPT Version :9

• Sequence 1: NP_650257.1
• Gene: pic / 41611
• FlyBaseID: FBgn0260962
• Length: 1140
• Species: Drosophila melanogaster
• Sequence 2: NP_502299.1
• Gene: ddb-1 / 178156
• WormBaseID: WBGene00010890
• Length: 1134
• Species: Caenorhabditis elegans
• Alignment Length: 1175
• Identity: 426/1175 - (36%)
• Similarity: 693/1175 - (58%)
• Gaps: 84/1175 - (7%)

  Fly     5 YVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRPLKEINING---TIAVMRH 66
            |.|:|:|.:.||..:.||||...::|||:||.|::::.||:||||:.:.||.|.|   |||:::.
 Worm     5 YCVSAKKASVVVESVVGNFTGHENVNLIVARGNRIDVQLVSPEGLKNVCEIPIYGQVLTIALVKC 69

  Fly    67 FRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAIDPKARVI 131
            .|   ..:..|.::|.::::.||..|...    |||:|.|.::|..|..:: .:.:....:..:|
 Worm    70 KR---DKRHSLIVVTEKWHMAILAYRDGK----VVTRAAGCIADPTGRATD-NLFSLTIHRNGLI 126

  Fly   132 GMCLYQGLFTIIPMDKDASELKATNLRMDELNVYDVEFLHGCLNPT--VIVIHKDSDGRHVKSHE 194
            .:..::|...:|..: ..::|:..|:|.|..||.|.:|:....:..  |..|:.|..|:|::..:
 Worm   127 AIRAFEGSVKMIQWE-SGTDLRHFNVRFDYPNVSDFKFVDTGEDDVYRVAFIYDDDHGKHLQFSD 190

  Fly   195 INLRDKEFMKIAWKQDNVETEATMLIPVPSPIGGVIVIGRESIVYHDGSNYHAVAPLT---FRQS 256
            :|:.||||...: :|.::..::::|||||..||||||:|..|::|....|...|.|.|   ...:
 Worm   191 LNMHDKEFRTYS-RQASIAADSSVLIPVPHAIGGVIVLGSNSVLYKPNDNLGEVVPYTCSLLENT 254

  Fly   257 TINCYARVSSNGLRYLLGNMDGQLYMLFLGTAETSKGVTVKDIKVEQLGEISIPECITYLDNGFL 321
            |..|:..|.::|.|:||.:.||:|.||.|...|:..|.|||:::::.|||.||.:.|.|:|||.:
 Worm   255 TFTCHGIVDASGERFLLSDTDGRLLMLLLNVTESQSGYTVKEMRIDYLGETSIADSINYIDNGVV 319

  Fly   322 YIGARHGDSQLVRLNSEAIDGSYVVPVENFTNLAPILDIAVVDLDRQGQGQIITCSGSFKDGSLR 386
            ::|:|.|||||:||.:|...|||.|.:|.::|:.||.|:.:|:.|  ||.|::||:|:.||||||
 Worm   320 FVGSRLGDSQLIRLMTEPNGGSYSVILETYSNIGPIRDMVMVESD--GQPQLVTCTGADKDGSLR 382

  Fly   387 IIRIGIGIQEHACIDLPGIKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEEVEETEIPGFA 451
            :||.||||.|.|.:||.|:.|::.:::   :|..:|.::::....|.:|.::|||:|:.::....
 Worm   383 VIRNGIGIDELASVDLAGVVGIFPIRL---DSNADNYVIVSLSDETHVLQITGEELEDVKLLEIN 444

  Fly   452 SDLQTFLCSNV----DYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTT--QILVA 510
            :||.|...|.:    |...::|.|...:||:||:  .|...|.||....|..||.|..  ||::|
 Worm   445 TDLPTIFASTLFGPNDSGIILQATEKQIRLMSSS--GLSKFWEPTNGEIISKVSVNAANGQIVLA 507

  Fly   511 SACDIFY----IVIEDGSLREQ--SRRTLAYEVACLDIT-PLDETQKKSDLVAVGLWTDISAVIL 568
             |.|..|    ||.|.|:|..|  :.:....|:||||:: ..|:...|:..:.:..|:..:..::
 Worm   508 -ARDTVYLLTCIVDEMGALDIQLTAEKKFENEIACLDLSNEGDDPNNKATFLVLAFWSTFAMEVI 571

  Fly   569 SLPDLETIYTEKLSGEIIPRSILMTTFEGIHYLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGTQ 633
            .||||.|:....|..:||||||:.|..|.:||||.|.|||::.|::.|..||...:.||..:||:
 Worm   572 QLPDLITVCHTDLPTKIIPRSIIATCIEEVHYLLVAFGDGALVYYVFDIKTGTHGEPKKSNVGTR 636

  Fly   634 PTTLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNAV 698
            |.:|...|:.:..::|.|||||.:|:|::.||||||||:|.|:.:|||::.||.|.|.:::.|::
 Worm   637 PPSLHRVRNKNRQHLFVCSDRPVIIFSASKKLVFSNVNVKLVDTVCSLSSSAYRDCLVISDGNSM 701

  Fly   699 ILGTIDEIQKLHIRTVPLGEGPRRIAYQESSQTFAVSTLRIDVHGRGGAKPLRNSASTQAQNITC 763
            :.||:|:|||:|:|::|:||...|||||:|:.|:.|.:               |...::|:.:..
 Worm   702 VFGTVDDIQKIHVRSIPMGESVLRIAYQKSTSTYGVCS---------------NRTESKAERVFA 751

  Fly   764 SSNFL------PKPGGGNSTAANAEVGQEIDVHNLLVIDQNTFEVLHAHQFVAPETISSLMSAKL 822
            |.|.|      ||..   ||.|:.:........:.:|:|||||:|||:|:|...||..|.:|.:.
 Worm   752 SKNALVTSQSRPKVA---STRADMDESPPNTTSSFMVLDQNTFQVLHSHEFGPWETALSCISGQF 813

  Fly   823 GDDPNTYYVVATSLVIPEEPEPKVGRIIIFHYHE---NKLTQVAETKVDGTCYALVEFNGKVLAG 884
            .:|.:|||||.|.|:.|:|.|.|:|||::|...:   :||.:|.|..|.|:..|:...|||::|.
 Worm   814 TNDSSTYYVVGTGLIYPDETETKIGRIVVFEVDDVERSKLRRVHELVVRGSPLAIRILNGKLVAA 878

  Fly   885 IGSFVRLYEWTNEKELRMECNIQNMIAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARD 949
            |.|.:||:|||.:||||:||:..|.:.||.||...:.:.|.|:|||::||.::.:||.|.|:|:|
 Worm   879 INSSIRLFEWTTDKELRLECSSFNHVIALDLKVMNEEVAVADVMRSVSLLSYRMLEGNFEEVAKD 943

  Fly   950 CEPKWMRAVEILDDDTFLGSETNGNLFVCQKD-SAATTDEERQLLPELARFHLGDTVNVFRHGSL 1013
            ...:||...|.:..::.||.|.:.|||..:.| :...||:.|.:|.....::||:...|....:|
 Worm   944 WNSQWMVTCEFITAESILGGEAHLNLFTVEVDKTRPITDDGRYVLEPTGYWYLGELPKVMTRSTL 1008

  Fly  1014 VMQ---NVGERTTPINGCVLYGTCNGAIGIVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHTYYR 1075
            |:|   ::.:.:.||    ::||..|.||::.||...:..||..:|:.:...:|:...|||:.||
 Worm  1009 VIQPEDSIIQYSQPI----MFGTNQGTIGMIVQIDDKWKKFLIAIEKAIADSVKNCMHIEHSSYR 1069

  Fly  1076 NFQINSKVEPSEGFIDGDLIESFLDLSRDKMRDAV-----QGLELTLNGERKSADVEDVIKIVED 1135
            .|....:.||..||:||||:||.||:.|....|.:     :|.:.:|     ..|..:::|::||
 Worm  1070 TFVFQKRAEPPSGFVDGDLVESILDMDRSVAMDILSKVSDKGWDPSL-----PRDPVEILKVIED 1129

  Fly  1136 LTRMH 1140
            |.|||
 Worm  1130 LARMH 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pic	NP_650257.1	SFT1	13..1139	CDD:227490	419/1164 (36%)
		MMS1_N	75..542	CDD:287414	168/483 (35%)
		CPSF_A	792..1100	CDD:281209	122/314 (39%)
ddb-1	NP_502299.1	MMS1_N	75..544	CDD:287414	168/483 (35%)
		CPSF_A	781..1094	CDD:281209	122/316 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167654
Domainoid	1	1.000	267	1.000	Domainoid score	I991
eggNOG	1	0.900	-	-		E1_KOG1897
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	725	1.000	Inparanoid score	I322
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55223
OrthoDB	1	1.010	-	-		D146622at2759
OrthoFinder	1	1.000	-	-		FOG0005098
OrthoInspector	1	1.000	-	-		oto18959
orthoMCL	1	0.900	-	-		OOG6_102651
Panther	1	1.100	-	-	LDO	PTHR10644
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R303
SonicParanoid	1	1.000	-	-		X3618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840