DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pic and DDB1

DIOPT Version :9

Sequence 1:NP_650257.1 Gene:pic / 41611 FlyBaseID:FBgn0260962 Length:1140 Species:Drosophila melanogaster
Sequence 2:NP_001914.3 Gene:DDB1 / 1642 HGNCID:2717 Length:1140 Species:Homo sapiens


Alignment Length:1145 Identity:699/1145 - (61%)
Similarity:876/1145 - (76%) Gaps:10/1145 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSHHYVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRPLKEININGTIAVMR 65
            ||::|||||||||||..|:||:|||..||||:||:|.::||.:||.|||||:||:.:.|.||||.
Human     1 MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVME 65

  Fly    66 HFRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAIDPKARV 130
            .|||...:||||||||.:||..|||.:...:.|.::|:|:|||.|.:|.|||.|:|..|||:.|:
Human    66 LFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRM 130

  Fly   131 IGMCLYQGLFTIIPMDKDASELKATNLRMDELNVYDVEFLHGCLNPTVIVIHKDSDGRHVKSHEI 195
            ||:.||.|||.:||:|:|..||||.|:|::||:|.||:||:||..||:..:::|..|||||::|:
Human   131 IGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEV 195

  Fly   196 NLRDKEFMKIAWKQDNVETEATMLIPVPSPIGGVIVIGRESIVYHDGSNYHAVAPLTFRQSTINC 260
            :||:|||.|..|||:|||.||:|:|.||.|.||.|:||:|||.||:|..|.|:||...:||||.|
Human   196 SLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVC 260

  Fly   261 YARVSSNGLRYLLGNMDGQLYMLFLGTAETSKG-VTVKDIKVEQLGEISIPECITYLDNGFLYIG 324
            :.||..||.|||||:|:|:|:||.|...|...| ||:||::||.|||.||.||:||||||.:::|
Human   261 HNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVG 325

  Fly   325 ARHGDSQLVRLNSEAID-GSYVVPVENFTNLAPILDIAVVDLDRQGQGQIITCSGSFKDGSLRII 388
            :|.||||||:||.::.: |||||.:|.||||.||:|:.||||:||||||::||||:||:||||||
Human   326 SRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRII 390

  Fly   389 RIGIGIQEHACIDLPGIKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEEVEETEIPGFASD 453
            |.||||.|||.||||||||:|.|:...:... ::||||:|||.||:|.|:||||||||:.||..|
Human   391 RNGIGIHEHASIDLPGIKGLWPLRSDPNRET-DDTLVLSFVGQTRVLMLNGEEVEETELMGFVDD 454

  Fly   454 LQTFLCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQILVASACDIFYI 518
            .|||.|.||.:.||||:||.||||||...||||:||:....:.|.|.|||::|::||....::|:
Human   455 QQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYL 519

  Fly   519 VIEDGSLREQSRRTLAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLPDLETIYTEKLSG 583
            .|....||:.|...:.:||||||||||.::...|.|.|:||||||||.||.||..|.::.|.|.|
Human   520 QIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGG 584

  Fly   584 EIIPRSILMTTFEGIHYLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGTQPTTLRTFRSLSTTNV 648
            |||||||||||||..||||||||||:::||.::..||.|:|:||||||||||.||||||||||||
Human   585 EIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNV 649

  Fly   649 FACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNAVILGTIDEIQKLHIRT 713
            ||||||||||||||||||||||||||||:||.||:..|||||||||.:.:.:|||||||||||||
Human   650 FACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRT 714

  Fly   714 VPLGEGPRRIAYQESSQTFAVSTLRIDVHG-RGGAKPLRNSASTQAQNITCSSNFLPKPGGGNST 777
            |||.|.||:|.|||.||.|.|.:.||:|.. .||...||.||||||.:.:.||:.|    ..:||
Human   715 VPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKL----FSSST 775

  Fly   778 AAN-AEVGQEIDVHNLLVIDQNTFEVLHAHQFVAPETISSLMSAKLGDDPNTYYVVATSLVIPEE 841
            |.: ...|:|::|||||:|||:||||||||||:..|...||:|.|||.|||||::|.|::|.|||
Human   776 APHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE 840

  Fly   842 PEPKVGRIIIFHYHENKLTQVAETKVDGTCYALVEFNGKVLAGIGSFVRLYEWTNEKELRMECNI 906
            .|||.|||::|.|.:.||..|||.:|.|..|::||||||:||.|.|.|||||||.|||||.|||.
Human   841 AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNH 905

  Fly   907 QNMIAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARDCEPKWMRAVEILDDDTFLGSET 971
            .|.|.||:||.|||||||||||||:.||.:|.|||.|.|||||..|.||.||||||||.|||:|.
Human   906 YNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAEN 970

  Fly   972 NGNLFVCQKDSAATTDEERQLLPELARFHLGDTVNVFRHGSLVMQNVGERTTPINGCVLYGTCNG 1036
            ..||||||||||||||||||.|.|:..||||:.||||.||||||||:||.:||..|.||:||.||
Human   971 AFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNG 1035

  Fly  1037 AIGIVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHTYYRNFQINSKVEPSEGFIDGDLIESFLDL 1101
            .||:||.:.:.:|:.|..::.||.|:|||||||||:::|:|....|.||:.|||||||||||||:
Human  1036 MIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDI 1100

  Fly  1102 SRDKMRDAVQGLEL-TLNGERKSADVEDVIKIVEDLTRMH 1140
            ||.||::.|..|:. ..:|.::.|..:|:||:||:|||:|
Human  1101 SRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH 1140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
picNP_650257.1 SFT1 13..1139 CDD:227490 687/1130 (61%)
MMS1_N 75..542 CDD:287414 266/468 (57%)
CPSF_A 792..1100 CDD:281209 201/307 (65%)
DDB1NP_001914.3 Interaction with CDT1. /evidence=ECO:0000269|PubMed:15448697 2..768 468/766 (61%)
WD repeat beta-propeller A 13..356 193/342 (56%)
MMS1_N 75..543 CDD:402179 266/468 (57%)
WD repeat beta-propeller B, Interaction with CUL4A 392..708 202/316 (64%)
WD repeat beta-propeller C 709..1043 215/337 (64%)
Interaction with CDT1 and CUL4A. /evidence=ECO:0000269|PubMed:15448697 771..1140 227/368 (62%)
CPSF_A 791..1099 CDD:397339 201/307 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160158
Domainoid 1 1.000 540 1.000 Domainoid score I266
eggNOG 1 0.900 - - E1_KOG1897
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1448
Inparanoid 1 1.050 1370 1.000 Inparanoid score I127
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55223
OrthoDB 1 1.010 - - D146622at2759
OrthoFinder 1 1.000 - - FOG0005098
OrthoInspector 1 1.000 - - oto88924
orthoMCL 1 0.900 - - OOG6_102651
Panther 1 1.100 - - LDO PTHR10644
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R303
SonicParanoid 1 1.000 - - X3618
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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