Protein Alignment pic and DDB1

DIOPT Version :10

• Sequence 1: NP_650257.1
• Gene: pic / 41611
• FlyBaseID: FBgn0260962
• Length: 1140
• Species: Drosophila melanogaster
• Sequence 2: NP_001914.3
• Gene: DDB1 / 1642
• HGNCID: 2717
• Length: 1140
• Species: Homo sapiens
• Alignment Length: 1145
• Identity: 699/1145 - (61%)
• Similarity: 876/1145 - (76%)
• Gaps: 10/1145 - (0%)

  Fly     1 MSHHYVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRPLKEININGTIAVMR 65
            ||::|||||||||||..|:||:|||..||||:||:|.::||.:||.|||||:||:.:.|.||||.
Human     1 MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVME 65

  Fly    66 HFRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAIDPKARV 130
            .|||...:||||||||.:||..|||.:...:.|.::|:|:|||.|.:|.|||.|:|..|||:.|:
Human    66 LFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRM 130

  Fly   131 IGMCLYQGLFTIIPMDKDASELKATNLRMDELNVYDVEFLHGCLNPTVIVIHKDSDGRHVKSHEI 195
            ||:.||.|||.:||:|:|..||||.|:|::||:|.||:||:||..||:..:::|..|||||::|:
Human   131 IGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEV 195

  Fly   196 NLRDKEFMKIAWKQDNVETEATMLIPVPSPIGGVIVIGRESIVYHDGSNYHAVAPLTFRQSTINC 260
            :||:|||.|..|||:|||.||:|:|.||.|.||.|:||:|||.||:|..|.|:||...:||||.|
Human   196 SLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVC 260

  Fly   261 YARVSSNGLRYLLGNMDGQLYMLFLGTAETSKG-VTVKDIKVEQLGEISIPECITYLDNGFLYIG 324
            :.||..||.|||||:|:|:|:||.|...|...| ||:||::||.|||.||.||:||||||.:::|
Human   261 HNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVG 325

  Fly   325 ARHGDSQLVRLNSEAID-GSYVVPVENFTNLAPILDIAVVDLDRQGQGQIITCSGSFKDGSLRII 388
            :|.||||||:||.::.: |||||.:|.||||.||:|:.||||:||||||::||||:||:||||||
Human   326 SRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRII 390

  Fly   389 RIGIGIQEHACIDLPGIKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEEVEETEIPGFASD 453
            |.||||.|||.||||||||:|.|:...:... ::||||:|||.||:|.|:||||||||:.||..|
Human   391 RNGIGIHEHASIDLPGIKGLWPLRSDPNRET-DDTLVLSFVGQTRVLMLNGEEVEETELMGFVDD 454

  Fly   454 LQTFLCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQILVASACDIFYI 518
            .|||.|.||.:.||||:||.||||||...||||:||:....:.|.|.|||::|::||....::|:
Human   455 QQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYL 519

  Fly   519 VIEDGSLREQSRRTLAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLPDLETIYTEKLSG 583
            .|....||:.|...:.:||||||||||.::...|.|.|:||||||||.||.||..|.::.|.|.|
Human   520 QIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGG 584

  Fly   584 EIIPRSILMTTFEGIHYLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGTQPTTLRTFRSLSTTNV 648
            |||||||||||||..||||||||||:::||.::..||.|:|:||||||||||.||||||||||||
Human   585 EIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNV 649

  Fly   649 FACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNAVILGTIDEIQKLHIRT 713
            ||||||||||||||||||||||||||||:||.||:..|||||||||.:.:.:|||||||||||||
Human   650 FACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRT 714

  Fly   714 VPLGEGPRRIAYQESSQTFAVSTLRIDVHG-RGGAKPLRNSASTQAQNITCSSNFLPKPGGGNST 777
            |||.|.||:|.|||.||.|.|.:.||:|.. .||...||.||||||.:.:.||:.|    ..:||
Human   715 VPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKL----FSSST 775

  Fly   778 AAN-AEVGQEIDVHNLLVIDQNTFEVLHAHQFVAPETISSLMSAKLGDDPNTYYVVATSLVIPEE 841
            |.: ...|:|::|||||:|||:||||||||||:..|...||:|.|||.|||||::|.|::|.|||
Human   776 APHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE 840

  Fly   842 PEPKVGRIIIFHYHENKLTQVAETKVDGTCYALVEFNGKVLAGIGSFVRLYEWTNEKELRMECNI 906
            .|||.|||::|.|.:.||..|||.:|.|..|::||||||:||.|.|.|||||||.|||||.|||.
Human   841 AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNH 905

  Fly   907 QNMIAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARDCEPKWMRAVEILDDDTFLGSET 971
            .|.|.||:||.|||||||||||||:.||.:|.|||.|.|||||..|.||.||||||||.|||:|.
Human   906 YNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAEN 970

  Fly   972 NGNLFVCQKDSAATTDEERQLLPELARFHLGDTVNVFRHGSLVMQNVGERTTPINGCVLYGTCNG 1036
            ..||||||||||||||||||.|.|:..||||:.||||.||||||||:||.:||..|.||:||.||
Human   971 AFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNG 1035

  Fly  1037 AIGIVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHTYYRNFQINSKVEPSEGFIDGDLIESFLDL 1101
            .||:||.:.:.:|:.|..::.||.|:|||||||||:::|:|....|.||:.|||||||||||||:
Human  1036 MIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDI 1100

  Fly  1102 SRDKMRDAVQGLEL-TLNGERKSADVEDVIKIVEDLTRMH 1140
            ||.||::.|..|:. ..:|.::.|..:|:||:||:|||:|
Human  1101 SRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pic	NP_650257.1	MMS1_N	75..542	CDD:463091	266/468 (57%)
		CPSF_A	790..1100	CDD:427182	203/309 (66%)
DDB1	NP_001914.3	Interaction with CDT1. /evidence=ECO:0000269|PubMed:15448697	2..768		468/766 (61%)
		WD repeat beta-propeller A	13..356		193/342 (56%)
		MMS1_N	75..543	CDD:463091	266/468 (57%)
		WD repeat beta-propeller B, Interaction with CUL4A	392..708		202/316 (64%)
		WD repeat beta-propeller C	709..1043		215/337 (64%)
		Interaction with CDT1 and CUL4A. /evidence=ECO:0000269|PubMed:15448697	771..1140		227/368 (62%)
		CPSF_A	789..1099	CDD:427182	203/309 (66%)