DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pic and Ddb1

DIOPT Version :9

Sequence 1:	NP_650257.1	Gene:	pic / 41611	FlyBaseID:	FBgn0260962	Length:	1140	Species:	Drosophila melanogaster
Sequence 2:	XP_006526702.1	Gene:	Ddb1 / 13194	MGIID:	1202384	Length:	1152	Species:	Mus musculus

Alignment Length:	1157	Identity:	699/1157 - (60%)
Similarity:	875/1157 - (75%)	Gaps:	22/1157 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHHYVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRPLKEININGTIAVMR 65
            ||::|||||||||||..|:||:|||..||||:||:|.::||.:||.|||||:||:.:.|.||||.
Mouse     1 MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVME 65

  Fly    66 HFRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAIDPKARV 130
            .|||...:||||||||.:||..|||.:...:.|.::|:|:|||.|.:|.|||.|:|..|||:.|:
Mouse    66 LFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRM 130

  Fly   131 IGMCLYQGLFTIIPMDKDASELKATNLRMDELNVYDVEFLHGCLNPTVIVIHK------------ 183
            ||:.||.|||.:||:|:|..||||.|:|::||:|.||:||:||..||:..:::
Mouse   131 IGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQPLKGDFGSPKTD 195

  Fly   184 DSDGRHVKSHEINLRDKEFMKIAWKQDNVETEATMLIPVPSPIGGVIVIGRESIVYHDGSNYHAV 248
            |..|||||::|::||:|||.|..|||:|||.||:|:|.||.|.||.|:||:|||.||:|..|.|:
Mouse   196 DPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAI 260

  Fly   249 APLTFRQSTINCYARVSSNGLRYLLGNMDGQLYMLFLGTAETSKG-VTVKDIKVEQLGEISIPEC 312
            ||...:||||.|:.||..||.|||||:|:|:|:||.|...|...| ||:||::||.|||.||.||
Mouse   261 APPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAEC 325

  Fly   313 ITYLDNGFLYIGARHGDSQLVRLNSEAID-GSYVVPVENFTNLAPILDIAVVDLDRQGQGQIITC 376
            :||||||.:::|:|.||||||:||.::.: |||||.:|.||||.||:|:.||||:||||||::||
Mouse   326 LTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTC 390

  Fly   377 SGSFKDGSLRIIRIGIGIQEHACIDLPGIKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEE 441
            ||:||:|||||||.||||.|||.||||||||:|.|:....... ::||||:|||.||:|.|:|||
Mouse   391 SGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPGRET-DDTLVLSFVGQTRVLMLNGEE 454

  Fly   442 VEETEIPGFASDLQTFLCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQ 506
            |||||:.||..|.|||.|.||.:.||||:||.||||||...||||:||:....:.|.|.|||::|
Mouse   455 VEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQGKNISVASCNSSQ 519

  Fly   507 ILVASACDIFYIVIEDGSLREQSRRTLAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLP 571
            ::||....::|:.|....||:.|...:.:||||||||||.::...|.|.|:||||||||.||.||
Mouse   520 VVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLP 584

  Fly   572 DLETIYTEKLSGEIIPRSILMTTFEGIHYLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGTQPTT 636
            ..|.::.|.|.||||||||||||||..||||||||||:::||.::..||.|:|:||||||||||.
Mouse   585 SFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTV 649

  Fly   637 LRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNAVILG 701
            ||||||||||||||||||||||||||||||||||||||||:||.||:..|||||||||.:.:.:|
Mouse   650 LRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIG 714

  Fly   702 TIDEIQKLHIRTVPLGEGPRRIAYQESSQTFAVSTLRIDVH-GRGGAKPLRNSASTQAQNITCSS 765
            |||||||||||||||.|.||:|.|||.||.|.|.:.||:|. ..||...||.||||||.:.:.||
Mouse   715 TIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDSSGGTTALRPSASTQALSSSVSS 779

  Fly   766 NFLPKPGGGNSTAAN-AEVGQEIDVHNLLVIDQNTFEVLHAHQFVAPETISSLMSAKLGDDPNTY 829
            :.|    ..:|||.: ...|:|::|||||:|||:||||||||||:..|...||:|.|||.|||||
Mouse   780 SKL----FSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTY 840

  Fly   830 YVVATSLVIPEEPEPKVGRIIIFHYHENKLTQVAETKVDGTCYALVEFNGKVLAGIGSFVRLYEW 894
            ::|.|::|.|||.|||.|||::|.|.:.||..|||.:|.|..|::||||||:||.|.|.||||||
Mouse   841 FIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEW 905

  Fly   895 TNEKELRMECNIQNMIAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARDCEPKWMRAVE 959
            |.|||||.|||..|.|.||:||.|||||||||||||:.||.:|.|||.|.|||||..|.||.|||
Mouse   906 TTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVE 970

  Fly   960 ILDDDTFLGSETNGNLFVCQKDSAATTDEERQLLPELARFHLGDTVNVFRHGSLVMQNVGERTTP 1024
            |||||.|||:|...||||||||||||||||||.|.|:..||||:.||||.||||||||:||.:||
Mouse   971 ILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGEASTP 1035

  Fly  1025 INGCVLYGTCNGAIGIVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHTYYRNFQINSKVEPSEGF 1089
            ..|.||:||.||.||:||.:.:.:|:.|..::.||.|:|||||||||:::|:|....|.||:.||
Mouse  1036 TQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGF 1100

  Fly  1090 IDGDLIESFLDLSRDKMRDAVQGLEL-TLNGERKSADVEDVIKIVEDLTRMH 1140
            |||||||||||:||.||::.|..|:. ..:|.::.|..:|:||:||:|||:|
Mouse  1101 IDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pic	NP_650257.1	SFT1	13..1139	CDD:227490	687/1142 (60%)
		MMS1_N	75..542	CDD:287414	266/480 (55%)
		CPSF_A	792..1100	CDD:281209	201/307 (65%)
Ddb1	XP_006526702.1	MMS1_N	75..555	CDD:371047	266/480 (55%)
Ddb1	XP_006526702.1	CPSF_A	803..1109	CDD:367377	199/305 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850532
Domainoid	1	1.000	541	1.000	Domainoid score	I268
eggNOG	1	0.900	-	-		E1_KOG1897
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1448
Inparanoid	1	1.050	1371	1.000	Inparanoid score	I127
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55223
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005098
OrthoInspector	1	1.000	-	-		oto92491
orthoMCL	1	0.900	-	-		OOG6_102651
Panther	1	1.100	-	-	LDO	PTHR10644
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R303
SonicParanoid	1	1.000	-	-		X3618
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790