Protein Alignment pic and Ddb1

DIOPT Version :10

• Sequence 1: NP_650257.1
• Gene: pic / 41611
• FlyBaseID: FBgn0260962
• Length: 1140
• Species: Drosophila melanogaster
• Sequence 2: NP_001397148.1
• Gene: Ddb1 / 13194
• MGIID: 1202384
• Length: 1152
• Species: Mus musculus
• Alignment Length: 1157
• Identity: 699/1157 - (60%)
• Similarity: 875/1157 - (75%)
• Gaps: 22/1157 - (1%)

  Fly     1 MSHHYVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRPLKEININGTIAVMR 65
            ||::|||||||||||..|:||:|||..||||:||:|.::||.:||.|||||:||:.:.|.||||.
Mouse     1 MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVME 65

  Fly    66 HFRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAIDPKARV 130
            .|||...:||||||||.:||..|||.:...:.|.::|:|:|||.|.:|.|||.|:|..|||:.|:
Mouse    66 LFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRM 130

  Fly   131 IGMCLYQGLFTIIPMDKDASELKATNLRMDELNVYDVEFLHGCLNPTVIVIHK------------ 183
            ||:.||.|||.:||:|:|..||||.|:|::||:|.||:||:||..||:..:::
Mouse   131 IGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQPLKGDFGSPKTD 195

  Fly   184 DSDGRHVKSHEINLRDKEFMKIAWKQDNVETEATMLIPVPSPIGGVIVIGRESIVYHDGSNYHAV 248
            |..|||||::|::||:|||.|..|||:|||.||:|:|.||.|.||.|:||:|||.||:|..|.|:
Mouse   196 DPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAI 260

  Fly   249 APLTFRQSTINCYARVSSNGLRYLLGNMDGQLYMLFLGTAETSKG-VTVKDIKVEQLGEISIPEC 312
            ||...:||||.|:.||..||.|||||:|:|:|:||.|...|...| ||:||::||.|||.||.||
Mouse   261 APPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAEC 325

  Fly   313 ITYLDNGFLYIGARHGDSQLVRLNSEAID-GSYVVPVENFTNLAPILDIAVVDLDRQGQGQIITC 376
            :||||||.:::|:|.||||||:||.::.: |||||.:|.||||.||:|:.||||:||||||::||
Mouse   326 LTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTC 390

  Fly   377 SGSFKDGSLRIIRIGIGIQEHACIDLPGIKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEE 441
            ||:||:|||||||.||||.|||.||||||||:|.|:....... ::||||:|||.||:|.|:|||
Mouse   391 SGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPGRET-DDTLVLSFVGQTRVLMLNGEE 454

  Fly   442 VEETEIPGFASDLQTFLCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQ 506
            |||||:.||..|.|||.|.||.:.||||:||.||||||...||||:||:....:.|.|.|||::|
Mouse   455 VEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQGKNISVASCNSSQ 519

  Fly   507 ILVASACDIFYIVIEDGSLREQSRRTLAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLP 571
            ::||....::|:.|....||:.|...:.:||||||||||.::...|.|.|:||||||||.||.||
Mouse   520 VVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLP 584

  Fly   572 DLETIYTEKLSGEIIPRSILMTTFEGIHYLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGTQPTT 636
            ..|.::.|.|.||||||||||||||..||||||||||:::||.::..||.|:|:||||||||||.
Mouse   585 SFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTV 649

  Fly   637 LRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNAVILG 701
            ||||||||||||||||||||||||||||||||||||||||:||.||:..|||||||||.:.:.:|
Mouse   650 LRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIG 714

  Fly   702 TIDEIQKLHIRTVPLGEGPRRIAYQESSQTFAVSTLRIDVH-GRGGAKPLRNSASTQAQNITCSS 765
            |||||||||||||||.|.||:|.|||.||.|.|.:.||:|. ..||...||.||||||.:.:.||
Mouse   715 TIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDSSGGTTALRPSASTQALSSSVSS 779

  Fly   766 NFLPKPGGGNSTAAN-AEVGQEIDVHNLLVIDQNTFEVLHAHQFVAPETISSLMSAKLGDDPNTY 829
            :.|    ..:|||.: ...|:|::|||||:|||:||||||||||:..|...||:|.|||.|||||
Mouse   780 SKL----FSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTY 840

  Fly   830 YVVATSLVIPEEPEPKVGRIIIFHYHENKLTQVAETKVDGTCYALVEFNGKVLAGIGSFVRLYEW 894
            ::|.|::|.|||.|||.|||::|.|.:.||..|||.:|.|..|::||||||:||.|.|.||||||
Mouse   841 FIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEW 905

  Fly   895 TNEKELRMECNIQNMIAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARDCEPKWMRAVE 959
            |.|||||.|||..|.|.||:||.|||||||||||||:.||.:|.|||.|.|||||..|.||.|||
Mouse   906 TTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVE 970

  Fly   960 ILDDDTFLGSETNGNLFVCQKDSAATTDEERQLLPELARFHLGDTVNVFRHGSLVMQNVGERTTP 1024
            |||||.|||:|...||||||||||||||||||.|.|:..||||:.||||.||||||||:||.:||
Mouse   971 ILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGEASTP 1035

  Fly  1025 INGCVLYGTCNGAIGIVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHTYYRNFQINSKVEPSEGF 1089
            ..|.||:||.||.||:||.:.:.:|:.|..::.||.|:|||||||||:::|:|....|.||:.||
Mouse  1036 TQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGF 1100

  Fly  1090 IDGDLIESFLDLSRDKMRDAVQGLEL-TLNGERKSADVEDVIKIVEDLTRMH 1140
            |||||||||||:||.||::.|..|:. ..:|.::.|..:|:||:||:|||:|
Mouse  1101 IDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pic	NP_650257.1	MMS1_N	75..542	CDD:463091	266/480 (55%)
		CPSF_A	790..1100	CDD:427182	203/309 (66%)
Ddb1	NP_001397148.1	MMS1_N	75..555	CDD:463091	266/480 (55%)
		WD repeat beta-propeller B, Interaction with CUL4A. /evidence=ECO:0000250	403..720		203/317 (64%)
		WD repeat beta-propeller C. /evidence=ECO:0000250	721..1055		215/337 (64%)
		Interaction with CDT1 and CUL4A. /evidence=ECO:0000250	783..1152		227/368 (62%)
		CPSF_A	801..1111	CDD:427182	203/309 (66%)