DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-2 and ECM10

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_010884.1	Gene:	ECM10 / 856682	SGDID:	S000000756	Length:	644	Species:	Saccharomyces cerevisiae

Alignment Length:	593	Identity:	288/593 - (48%)
Similarity:	398/593 - (67%)	Gaps:	44/593 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KIP--AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAF-NETERLIGDPAKNQVAMNAK 64
            |||  .||||||||.|.|.:.:.....||.|.:|:|||||.||| .:.|||:|:|||.|..:|::
Yeast    24 KIPDAVIGIDLGTTNSAVAIMEGKVPRIIENAEGSRTTPSVVAFTKDGERLVGEPAKRQSVINSE 88

  Fly    65 NTVFDAKRLIGRKFDDKKIQEDLKLWPFKVI-NEKGKPKIEVEFKGERKRFAPEEISSMVLTKMR 128
            ||:|..||||||:|:|.::|.|:...|||:: :..|...:|    ...:.::|.:|...:|.||:
Yeast    89 NTLFATKRLIGRRFEDAEVQRDINQVPFKIVKHSNGDAWVE----ARNRTYSPAQIGGFILNKMK 149

  Fly   129 EIAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGER 193
            |.||.||...||:|||||||||||:|||||||||.|.||||||::||||||||||||||:   |.
Yeast   150 ETAEAYLAKSVKNAVVTVPAYFNDAQRQATKDAGQIIGLNVLRVVNEPTAAALAYGLDKS---EP 211

  Fly   194 NVL-IFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGN 257
            .|: :|||||||||:|:|.||.| :||||:|.|||||||||||..|:......||::...|:..:
Yeast   212 KVIAVFDLGGGTFDISILDIDNG-IFEVKSTNGDTHLGGEDFDIYLLQEIISHFKKETGIDLSND 275

  Fly   258 ARALRRLRTACERAKRTLSS--STEASLEI---DAL---HEGIDFYSKISRARFEELNMDLFRST 314
            ..|::|:|.|.|:||..|||  |||.:|..   ||.   |..:.|    ||.:.|.:...|...|
Yeast   276 RMAVQRIREAAEKAKIELSSTLSTEINLPFITADAAGPKHIRMPF----SRVQLENITAPLIDRT 336

  Fly   315 MQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAA 379
            :.||::||.||::....|.||:||||.:|:||:...::.|| ||..:.::|||||||.|||:|||
Yeast   337 VDPVKKALKDARITASDISDVLLVGGMSRMPKVADTVKKLF-GKDASKAVNPDEAVALGAAIQAA 400

  Fly   380 ILTGVGSSQIQDLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVY 444
            :|:|    ::.|:||:||.||||||||.|||.|.|:.||:.||.|:.|||:|.:..|.:|.::|:
Yeast   401 VLSG----EVTDVLLLDVTPLSLGIETLGGVFTKLIPRNSTIPNKKSQIFSTAASGQTSVEVKVF 461

  Fly   445 EGERAMTKDNNLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKG 509
            :|||.:.|||.|:|.|.|.||||||:|.|||||.||::|:||:||:|||.::.|...||::...|
Yeast   462 QGERELVKDNKLIGNFTLAGIPPAPKGTPQIEVTFDIDANGIINVSAKDLASHKDSSITVAGASG 526

  Fly   510 RLSKAEIDRMLSEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPS------GVLSETERS 568
             ||..|||||::|||:||.:|..:|..:::.|..:       |..:|..:      |.|.:|:..
Yeast   527 -LSDTEIDRMVNEAERYKNQDRARRNAIETANKAD-------QLANDTENSIKEFEGKLDKTDSQ 583

  Fly   569 KVRDKCSS 576
            :::|:.||
Yeast   584 RLKDQISS 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	288/593 (49%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	194/386 (50%)
ECM10	NP_010884.1	dnaK	29..644	CDD:234715	285/588 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810