DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and SSZ1

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_011931.2	Gene:	SSZ1 / 856461	SGDID:	S000001106	Length:	538	Species:	Saccharomyces cerevisiae

Alignment Length:	557	Identity:	163/557 - (29%)
Similarity:	276/557 - (49%)	Gaps:	85/557 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PAIGIDLGTTYSCVGVWQNSK--VEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTV 67
            |.|||..|.|.|.: .:.|.|  |::|||..|.|..||.:::...:...|..|..|:..|.|||:
Yeast     4 PVIGITFGNTSSSI-AYINPKNDVDVIANPDGERAIPSALSYVGEDEYHGGQALQQLIRNPKNTI 67

  Fly    68 FDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFK---------GERKRFAPEEISSMV 123
            .:.:..||..||...:.        |..|  |.|.:||:.|         |:.::...:|:.|..
Yeast    68 INFRDFIGLPFDKCDVS--------KCAN--GAPAVEVDGKVGFVISRGEGKEEKLTVDEVVSRH 122

  Fly   124 LTKMREIAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN 188
            |.:::..||.|:|..||:||:|||..|::.|:.|.|.:.:..||.:::.||||:||.||:.....
Yeast   123 LNRLKLAAEDYIGSAVKEAVLTVPTNFSEEQKTALKASAAKIGLQIVQFINEPSAALLAHAEQFP 187

  Fly   189 LKGERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSD 253
            .:.:.||::.|.||...|.:|:::..| :|.:.|||.|..|||::.|..||.:||.||::|::::
Yeast   188 FEKDVNVVVADFGGIRSDAAVIAVRNG-IFTILATAHDLSLGGDNLDTELVEYFASEFQKKYQAN 251

  Fly   254 IKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPV 318
            .:.|||:|.:|:......|:|||::|.|::.||:|.:|.|:::.|:|.|:|.:...:|......|
Yeast   252 PRKNARSLAKLKANSSITKKTLSNATSATISIDSLADGFDYHASINRMRYELVANKVFAQFSSFV 316

  Fly   319 ERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQ-------DLFGGKQLNLSINPDEAVAYGAAV 376
            :..::.|::|...|..|:|.||.:..||:...|:       ::.|.:..|.|.||:|..|.|||:
Yeast   317 DSVIAKAELDPLDIDAVLLTGGVSFTPKLTTNLEYTLPESVEILGPQNKNASNNPNELAASGAAL 381

  Fly   377 QAAILTGVGSSQIQDLL---LVDVAPLS--LGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQ 436
            ||.:::...:.::.:.|   :|:...|.  :|:..|.|....::......|.:::   .|....:
Yeast   382 QARLISDYDADELAEALQPVIVNTPHLKKPIGLIGAKGEFHPVLLAETSFPVQKK---LTLKQAK 443

  Fly   437 NAVTIQVYEGE--------RAMTKDNNL-----------------------------LGTFNLTG 464
            ....|.||||:        ..:.|:.|.                             ||..|..|
Yeast   444 GDFLIGVYEGDHHIEEKTLEPIPKEENAEEDDESEWSDDEPEVVREKLYTLGTKLMELGIKNANG 508

  Fly   465 IPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEK 501
                      :|:.|::|.||.|.|.|:|..||.:.|
Yeast   509 ----------VEIIFNINKDGALRVTARDLKTGNAVK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	163/557 (29%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	131/393 (33%)
SSZ1	NP_011931.2	ScSsz1p_like_NBD	4..384	CDD:212674	131/391 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810