Protein Alignment Hsc70-2 and LHS1

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_012850.1
• Gene: LHS1 / 853789
• SGDID: S000001556
• Length: 881
• Species: Saccharomyces cerevisiae
• Alignment Length: 684
• Identity: 164/684 - (23%)
• Similarity: 292/684 - (42%)
• Gaps: 118/684 - (17%)

  Fly     1 MGKIPAI-GIDLG-TTYSCVGVWQNSKVEIIANDQGNRTTPSYVAF-----------NETERLIG 52
            :|.:.|: |:|.| .....:.|...:.:|::...:..|...|.::.           |..||:.|
Yeast    16 IGSLAAVLGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYG 80

  Fly    53 DPAKNQVAMNAKNTVFDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIE--------VEFKG 109
            ....:......:||:...|.|:|:..:|:..         ..:..|..|.:|        :.|..
Yeast    81 SAVGSLATRFPQNTLLHLKPLLGKSLEDETT---------VTLYSKQHPGLEMVSTNRSTIAFLV 136

  Fly   110 ERKRFAPEEISSMVLTKMREIAEVYLGGKVKDA---------VVTVPAYFNDSQRQATKDAGSI- 164
            :...:..||:.:|.:.::...|...|  |.:||         ..|:|.:|:..||:|..||.||
Yeast   137 DNVEYPLEELVAMNVQEIANRANSLL--KDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSIT 199

  Fly   165 AGLNVLRIINEPTAAALAYGLDKNL--KGE-RNVLIFDLGGGTFDVSVLSI------DEGSLFEV 220
            .|:....:::|..:.|:.:.|.:..  .|| ::.:::|:|.|:...|:.||      .:....|.
Yeast   200 TGIEETYLVSEGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEF 264

  Fly   221 KATAGDTHLGGE----DFDNRLVNHFAEEFKRKHKSDIKGNARALRRLRTACERAKRTLSSSTEA 281
            :....:.||||.    |..:.:.|.|.|........::..|.:||.::..|.|:||..||:::||
Yeast   265 EGYGYNPHLGGAKFTMDIGSLIENKFLETHPAIRTDELHANPKALAKINQAAEKAKLILSANSEA 329

  Fly   282 SLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDA----KMDKKAIHDVVLVGGST 342
            |:.|::|...|||.:.|:|..|||...|.....::|:..|::..    ..:...|:.|:|.|||:
Yeast   330 SINIESLINDIDFRTSITRQEFEEFIADSLLDIVKPINDAVTKQFGGYGTNLPEINGVILAGGSS 394

  Fly   343 RIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGV---GSSQIQDLLLVDVAPLSLGI 404
            |||.:|..|..|...:::..::|.||     :||...::.|:   .|.:.:.|.:||     ..:
Yeast   395 RIPIVQDQLIKLVSEEKVLRNVNADE-----SAVNGVVMRGIKLSNSFKTKPLNVVD-----RSV 449

  Fly   405 ETAGGVMTNLVE------RNARIPCKQQQIFTTYSDNQNAVTIQVYE-GERAMTKDNNLLGTFNL 462
            .|....::|..|      |.:..|.|...:..|.....|..||.::| |:...|...|.....|.
Yeast   450 NTYSFKLSNESELYDVFTRGSAYPNKTSILTNTTDSIPNNFTIDLFENGKLFETITVNSGAIKNS 514

  Fly   463 TGIPPAPRGVPQIEVAFDLNADGILNVN------AKDNSTGKSEKITISNDKG------------ 509
            ........|| ...:.|||::|.:.::.      ..:|..|.|::|   .:||
Yeast   515 YSSDKCSSGV-AYNITFDLSSDRLFSIQEVNCICQSENDIGNSKQI---KNKGSRLAFTSEDVEI 575

  Fly   510 -RLSKAEIDRMLSEAEKYKVEDDRQRERVQSKNN---LEAYIYACRQAVDDAPSGVLSETERSKV 570
             |||.:|..|:   .|..|:.|.:.:||.|.:.|   ||:.:|..|..:.|  ..|:....:|:|
Yeast   576 KRLSPSERSRL---HEHIKLLDKQDKERFQFQENLNVLESNLYDARNLLMD--DEVMQNGPKSQV 635

  Fly   571 RDKCSSE-----ASWLDKNSL-AEKEEFESHLKE 598
            .:  .||     ..||:..|. .:.|:..|.::|
Yeast   636 EE--LSEMVKVYLDWLEDASFDTDPEDIVSRIRE 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	164/684 (24%)
LHS1	NP_012850.1	ASKHA_NBD_HSP70_HYOU1	21..431	CDD:466828	103/425 (24%)