Protein Alignment Hsc70-2 and KAR2

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_012500.3
• Gene: KAR2 / 853418
• SGDID: S000003571
• Length: 682
• Species: Saccharomyces cerevisiae
• Alignment Length: 627
• Identity: 361/627 - (57%)
• Similarity: 467/627 - (74%)
• Gaps: 8/627 - (1%)

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            ||||||||||||.|.:|.|.||:||:||||.|||||||.:.||||||.||||||.|.:||:||.|
Yeast    53 IGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFTDDERLIGDAAKNQVAANPQNTIFDIK 117

  Fly    72 RLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYLG 136
            ||||.|::|:.:|:|:|..||.|:|:.|||.:||..|||:|.|.|||||.|:|.||::|||.|||
Yeast   118 RLIGLKYNDRSVQKDIKHLPFNVVNKDGKPAVEVSVKGEKKVFTPEEISGMILGKMKQIAEDYLG 182

  Fly   137 GKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDLG 201
            .||..|||||||||||:|||||||||:|||||||||:|||||||:||||||:.| |..::::|||
Yeast   183 TKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKSDK-EHQIIVYDLG 246

  Fly   202 GGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLRT 266
            |||||||:|||:.| :|||:||:|||||||||||.::|....:.||:||..|:..|.:||.:|:.
Yeast   247 GGTFDVSLLSIENG-VFEVQATSGDTHLGGEDFDYKIVRQLIKAFKKKHGIDVSDNNKALAKLKR 310

  Fly   267 ACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKKA 331
            ..|:|||.|||.....:|||:..:|||....::||:|||||:|||:.|::|||:.|.|:.::||.
Yeast   311 EAEKAKRALSSQMSTRIEIDSFVDGIDLSETLTRAKFEELNLDLFKKTLKPVEKVLQDSGLEKKD 375

  Fly   332 IHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVD 396
            :.|:|||||||||||:|:||:..|.||:.:..|||||||||||||||.:|:  |...::|::|:|
Yeast   376 VDDIVLVGGSTRIPKVQQLLESYFDGKKASKGINPDEAVAYGAAVQAGVLS--GEEGVEDIVLLD 438

  Fly   397 VAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTFN 461
            |..|:|||||.|||||.|::||..||.|:.|||:|..|||..|.|:||||||||:|||||||.|.
Yeast   439 VNALTLGIETTGGVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVMIKVYEGERAMSKDNNLLGKFE 503

  Fly   462 LTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAEKY 526
            ||||||||||||||||.|.|:|:|||.|:|.|..|||||.|||:||||||::.|||||:.||||:
Yeast   504 LTGIPPAPRGVPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQEEIDRMVEEAEKF 568

  Fly   527 KVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWLDKN-SLAEKE 590
            ..||...:.:|:|:|.||.|.::.:..|:......|.|.::..:.|..:....|||.| ..|..|
Yeast   569 ASEDASIKAKVESRNKLENYAHSLKNQVNGDLGEKLEEEDKETLLDAANDVLEWLDDNFETAIAE 633

  Fly   591 EFESHLKECQRICTPIMSKIHGGKKGKSSMGKGSHPTVEEVD 632
            :|:...:...::..||.||::||..|.   |...:...:|.|
Yeast   634 DFDEKFESLSKVAYPITSKLYGGADGS---GAADYDDEDEDD 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	360/625 (58%)
KAR2	NP_012500.3	HSP70	52..654	CDD:394970	355/604 (59%)