DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and BIP3

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_172382.4	Gene:	BIP3 / 837429	AraportID:	AT1G09080	Length:	675	Species:	Arabidopsis thaliana

Alignment Length:	629	Identity:	359/629 - (57%)
Similarity:	478/629 - (75%)	Gaps:	14/629 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            ||||||||||||||:.|..|||||||||||.|||:|||.:||||||:.||||.|.|.:.|:||.|
plant    53 IGIDLGTTYSCVGVYHNKHVEIIANDQGNRITPSWVAFTDTERLIGEAAKNQAAKNPERTIFDPK 117

  Fly    72 RLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYLG 136
            |||||||||..:|.|:|..|:||:|:.|||.|:|:.|||.|.|:|||||:|:||||:|.||.:||
plant   118 RLIGRKFDDPDVQRDIKFLPYKVVNKDGKPYIQVKVKGEEKLFSPEEISAMILTKMKETAEAFLG 182

  Fly   137 GKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDLG 201
            .|:||||:||||||||:|||||||||:||||||:|||||||.||:||||||. .||.|:|::|||
plant   183 KKIKDAVITVPAYFNDAQRQATKDAGAIAGLNVVRIINEPTGAAIAYGLDKK-GGESNILVYDLG 246

  Fly   202 GGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLRT 266
            |||||||:|:||.| :|||.:|:|||||||||||:|::::|.:..|:|:..||..:.:||.:||.
plant   247 GGTFDVSILTIDNG-VFEVLSTSGDTHLGGEDFDHRVMDYFIKLVKKKYNKDISKDHKALGKLRR 310

  Fly   267 ACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKKA 331
            .||.|||:||:..:..:||::|.:|:||...::||||||||||||:.||:||::||.||.:.|..
plant   311 ECELAKRSLSNQHQVRVEIESLFDGVDFSEPLTRARFEELNMDLFKKTMEPVKKALKDAGLKKSD 375

  Fly   332 IHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVD 396
            |.::|||||||||||:|::|:|.|.||:.:...|||||||||||||..:|:|.|..:.|::||:|
plant   376 IDEIVLVGGSTRIPKVQQMLKDFFDGKEPSKGTNPDEAVAYGAAVQGGVLSGEGGEETQNILLLD 440

  Fly   397 VAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTFN 461
            ||||||||||.||||||::.||..||.|:.|:||||.|.|..|||.||||||:|||||..||.|:
plant   441 VAPLSLGIETVGGVMTNIIPRNTVIPTKKSQVFTTYQDQQTTVTINVYEGERSMTKDNRELGKFD 505

  Fly   462 LTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAEKY 526
            ||||.|||||||||||.|:::|:|||.|.|:|.....|:.|||:||||||::.||:.|:.|||::
plant   506 LTGILPAPRGVPQIEVTFEVDANGILQVKAEDKVAKTSQSITITNDKGRLTEEEIEEMIREAEEF 570

  Fly   527 KVEDDRQRERVQSKNNLEAYIYACRQAVDDAP--SGVLSETERSKVRDKCSSEASWLDKNSLAEK 589
            ..||...:|::.::|.||.|:|..:..|.|..  :..:|:.::.|:.........||::|..|||
plant   571 AEEDKIMKEKIDARNKLETYVYNMKSTVADKEKLAKKISDEDKEKMEGVLKEALEWLEENVNAEK 635

  Fly   590 EEFESHLKECQRICTPIMSKIHGGKKGKSSMGKGSHPTVEEVDG 633
            |:::..|||.:.:|.|::..::...:|::          |:.||
plant   636 EDYDEKLKEVELVCDPVIKSVYEKTEGEN----------EDDDG 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	357/626 (57%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	240/374 (64%)
BIP3	NP_172382.4	HSPA5-like_NBD	50..423	CDD:212681	240/371 (65%)
BIP3	NP_172382.4	PTZ00009	53..658	CDD:240227	355/606 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730