DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and BIP2

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_001331824.1	Gene:	BIP2 / 834207	AraportID:	AT5G42020	Length:	673	Species:	Arabidopsis thaliana

Alignment Length:	635	Identity:	374/635 - (58%)
Similarity:	490/635 - (77%)	Gaps:	9/635 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKIPAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKN 65
            :|.:  ||||||||||||||::|..|||||||||||.|||:|.|.::|||||:.||||.|:|.:.
plant    39 LGSV--IGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVGFTDSERLIGEAAKNQAAVNPER 101

  Fly    66 TVFDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFK-GERKRFAPEEISSMVLTKMRE 129
            ||||.||||||||:||::|:|.||.|::::|:.|||.|:|:.| ||.|.|:|||||:|:||||:|
plant   102 TVFDVKRLIGRKFEDKEVQKDRKLVPYQIVNKDGKPYIQVKIKDGETKVFSPEEISAMILTKMKE 166

  Fly   130 IAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERN 194
            .||.|||.|:|||||||||||||:|||||||||.||||||.||||||||||:||||||. .||:|
plant   167 TAEAYLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKK-GGEKN 230

  Fly   195 VLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNAR 259
            :|:|||||||||||||:||.| :|||.:|.|||||||||||:|::.:|.:..|:||:.||..:.:
plant   231 ILVFDLGGGTFDVSVLTIDNG-VFEVLSTNGDTHLGGEDFDHRIMEYFIKLIKKKHQKDISKDNK 294

  Fly   260 ALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSD 324
            ||.:||..||||||.|||..:..:||::|.:|:|....::||||||||.||||.||.||::|:.|
plant   295 ALGKLRRECERAKRALSSQHQVRVEIESLFDGVDLSEPLTRARFEELNNDLFRKTMGPVKKAMDD 359

  Fly   325 AKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQI 389
            |.:.|..|.::|||||||||||:|:||:|.|.||:.|..:|||||||||||||..||:|.|..:.
plant   360 AGLQKSQIDEIVLVGGSTRIPKVQQLLKDFFEGKEPNKGVNPDEAVAYGAAVQGGILSGEGGDET 424

  Fly   390 QDLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDN 454
            :|:||:|||||:|||||.|||||.|:.||..||.|:.|:||||.|.|..|:|||:||||::|||.
plant   425 KDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSLTKDC 489

  Fly   455 NLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRM 519
            .|||.|:|||:||||||.|||||.|:::|:|||||.|:|.::||||||||:|:|||||:.|||||
plant   490 RLLGKFDLTGVPPAPRGTPQIEVTFEVDANGILNVKAEDKASGKSEKITITNEKGRLSQEEIDRM 554

  Fly   520 LSEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP--SGVLSETERSKVRDKCSSEASWLD 582
            :.|||::..||.:.:|::.::|.||.|:|..:..|.|..  :..|...|:.|:.........|||
plant   555 VKEAEEFAEEDKKVKEKIDARNALETYVYNMKNQVSDKDKLADKLEGDEKEKIEAATKEALEWLD 619

  Fly   583 KNSLAEKEEFESHLKECQRICTPIMSKIHGGKKGKSSMGKGSHPTVEEVD 632
            :|..:||||::..|||.:.:|.||::.::  ::...:.|.|...:.||.|
plant   620 ENQNSEKEEYDEKLKEVEAVCNPIITAVY--QRSGGAPGAGGESSTEEED 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	373/633 (59%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	247/376 (66%)
BIP2	NP_001331824.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730