DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and Hsp70-2

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_195869.1	Gene:	Hsp70-2 / 831856	AraportID:	AT5G02490	Length:	653	Species:	Arabidopsis thaliana

Alignment Length:	650	Identity:	434/650 - (66%)
Similarity:	518/650 - (79%)	Gaps:	20/650 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKIPAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNT 66
            |:.||||||||||||||||||:.:|||||||||||||||||||.::||||||.||||||||..||
plant     5 GEGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPVNT 69

  Fly    67 VFDAKRLIGRKFDDKKIQEDLKLWPFKVINEKG-KPKIEVEFKGERKRFAPEEISSMVLTKMREI 130
            ||||||||||:|.|..:|.|.:||||.:|:... ||.|.||:|||.|:||.||||||||.|||||
plant    70 VFDAKRLIGRRFSDASVQSDRQLWPFTIISGTAEKPMIVVEYKGEEKQFAAEEISSMVLIKMREI 134

  Fly   131 AEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLK--GER 193
            ||.:||..||:|||||||||||||||||||||.|||||||||||||||||:||||||...  ||:
plant   135 AEAFLGTTVKNAVVTVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKKATSVGEK 199

  Fly   194 NVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNA 258
            |||||||||||||||:|:|:|| :||||||||||||||||||||:||||.:|||||:|.||.|..
plant   200 NVLIFDLGGGTFDVSLLTIEEG-IFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKNKQDITGQP 263

  Fly   259 RALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALS 323
            |||||||||||||||||||:.:.::|||:|:.|.||||.|:||||||:||||||..|:|||:.|.
plant   264 RALRRLRTACERAKRTLSSTAQTTIEIDSLYGGADFYSPITRARFEEMNMDLFRKCMEPVEKCLR 328

  Fly   324 DAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQ 388
            ||||||..:|::|||||||||||:|:||||.|.||:|..|||||||||||||||||||:|.|:.:
plant   329 DAKMDKSTVHEIVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEK 393

  Fly   389 IQDLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKD 453
            :|||||:||.|||||:||||||||.|::||..||.|::|:|:||||||..|.|||:|||||.|||
plant   394 VQDLLLLDVTPLSLGLETAGGVMTTLIQRNTTIPTKKEQVFSTYSDNQPGVLIQVFEGERARTKD 458

  Fly   454 NNLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDR 518
            |||||.|.|:||||||||||||.|.||::|:|||||:|:|.:|||..||||:||||||||.:|::
plant   459 NNLLGKFELSGIPPAPRGVPQITVCFDIDANGILNVSAEDKTTGKKNKITITNDKGRLSKEDIEK 523

  Fly   519 MLSEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSG-VLSETERSKVRDKCSSEASWLD 582
            |:.||||||.||:..:::|::||.||.|.|..|..:.|...| .|...::.||.|.......|||
plant   524 MVQEAEKYKSEDEEHKKKVEAKNALENYAYNMRNTIRDEKIGEKLPAADKKKVEDSIEEAIQWLD 588

  Fly   583 KNSLAEKEEFESHLKECQRICTPIMSKIHGGKKGKSSMGKGSH---------------PTVEEVD 632
            .|.|.|.:|||..:||.:.:|.||::|::.|..|..:.|.|:.               |.:||||
plant   589 GNQLGEADEFEDKMKELESVCNPIIAKMYQGGAGGEAGGPGASGMDEDEAPPASGGAGPKIEEVD 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	432/648 (67%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	290/378 (77%)
Hsp70-2	NP_195869.1	PTZ00009	5..653	CDD:240227	432/648 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74294
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730