DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and cpHsc70-1

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_194159.1	Gene:	cpHsc70-1 / 828531	AraportID:	AT4G24280	Length:	718	Species:	Arabidopsis thaliana

Alignment Length:	640	Identity:	280/640 - (43%)
Similarity:	402/640 - (62%)	Gaps:	40/640 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNET-ERLIGDPAKNQVAMNAKNTVFDA 70
            :|||||||.|.|...:..|..|:.|.:|.|||||.||:.:: :||:|..||.|..:|.:||.|..
plant    81 VGIDLGTTNSAVAAMEGGKPTIVTNAEGQRTTPSVVAYTKSGDRLVGQIAKRQAVVNPENTFFSV 145

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            ||.||||.::  :.|:.|...::|:.::.. .:::|.....|:||.||||:.||.|:.:.|..:|
plant   146 KRFIGRKMNE--VDEESKQVSYRVVRDENN-NVKLECPAINKQFAAEEISAQVLRKLVDDASRFL 207

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 200
            ..||..||:|||||||||||.||||||.||||.|||||||||||:||||.|:  |....:|:|||
plant   208 NDKVTKAVITVPAYFNDSQRTATKDAGRIAGLEVLRIINEPTAASLAYGFDR--KANETILVFDL 270

  Fly   201 GGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLR 265
            ||||||||||.:.:| :|||.:|:|||||||:|||.|:|:..|.|||:....|:..:.:||:||.
plant   271 GGGTFDVSVLEVGDG-VFEVLSTSGDTHLGGDDFDKRVVDWLAAEFKKDEGIDLLKDKQALQRLT 334

  Fly   266 TACERAKRTLSSSTEASLEIDALHEGID----FYSKISRARFEELNMDLFRSTMQPVERALSDAK 326
            .|.|:||..|||.|:.::.:..:....|    ..:.::||:||||..||......|||.:|.|||
plant   335 EAAEKAKIELSSLTQTNMSLPFITATADGPKHIETTLTRAKFEELCSDLLDRVRTPVENSLRDAK 399

  Fly   327 MDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQD 391
            :..|.|.:|:|||||||||.:|:|::.: .||:.|:::||||.||.||||||.:|.|    .:.|
plant   400 LSFKDIDEVILVGGSTRIPAVQELVRKV-TGKEPNVTVNPDEVVALGAAVQAGVLAG----DVSD 459

  Fly   392 LLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNL 456
            ::|:||.|||:|:||.|||||.::.||..:|..:.::|:|.:|.|.:|.|.|.:|||...:||..
plant   460 IVLLDVTPLSIGLETLGGVMTKIIPRNTTLPTSKSEVFSTAADGQTSVEINVLQGEREFVRDNKS 524

  Fly   457 LGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLS 521
            ||:|.|.||||||||||||||.||::|:|||:|:|.|..|||.:.|||:. ...|.|.|:|:|:.
plant   525 LGSFRLDGIPPAPRGVPQIEVKFDIDANGILSVSAVDKGTGKKQDITITG-ASTLPKDEVDQMVQ 588

  Fly   522 EAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWL-DKNS 585
            |||::..:|..:|:.:.:||..::.:|...:.:.:     |.|....:|::|..::...| ||..
plant   589 EAERFAKDDKEKRDAIDTKNQADSVVYQTEKQLKE-----LGEKIPGEVKEKVEAKLQELKDKIG 648

  Fly   586 LAEKEEFESHLKECQRICTPIMSKIH-----------------GGKKGKSSMGKG 623
            ....:|.:..:....:....|...::                 |...|.||..||
plant   649 SGSTQEIKDAMAALNQEVMQIGQSLYNQPGAGGPGAGPSPGGEGASSGDSSSSKG 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	280/640 (44%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	187/379 (49%)
cpHsc70-1	NP_194159.1	PLN03184	40..716	CDD:215618	280/640 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820