DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and HSP70T-2

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_180771.1	Gene:	HSP70T-2 / 817771	AraportID:	AT2G32120	Length:	563	Species:	Arabidopsis thaliana

Alignment Length:	536	Identity:	170/536 - (31%)
Similarity:	271/536 - (50%)	Gaps:	47/536 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVA----MNAKNT 66
            |:|||:||:...:.||..|:|.|:.|.:..:...|:|.|.:.....|  ..||:|    |.....
plant    30 ALGIDIGTSQCSIAVWNGSQVHILRNTRNQKLIKSFVTFKDEVPAGG--VSNQLAHEQEMLTGAA 92

  Fly    67 VFDAKRLIGRKFDDKKIQEDLKLWPFKV--INEKGKPKIEVEFKGERKRFAPEEISSMVLTKMRE 129
            :|:.|||:||...|..:.....| ||.|  ::...:|.|........:...|||:.::.|.::|.
plant    93 IFNMKRLVGRVDTDPVVHASKNL-PFLVQTLDIGVRPFIAALVNNAWRSTTPEEVLAIFLVELRL 156

  Fly   130 IAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLK---- 190
            :||..|...|::.|:|||..|:..|....:.|.::|||:|||::.||||.||.|...:.:.
plant   157 MAEAQLKRPVRNVVLTVPVSFSRFQLTRFERACAMAGLHVLRLMPEPTAIALLYAQQQQMTTHDN 221

  Fly   191 ----GERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHK 251
                .||..:||::|.|..||:| :...|.:.::||.|| :.:||||.....:.|.|..
plant   222 MGSGSERLAVIFNMGAGYCDVAV-TATAGGVSQIKALAG-SPIGGEDILQNTIRHIAPP------ 278

  Fly   252 SDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQ 316
                 |..|...||.|.:.|...|:......:|:| |..|......:.|..|||:|..:|....:
plant   279 -----NEEASGLLRVAAQDAIHRLTDQENVQIEVD-LGNGNKISKVLDRLEFEEVNQKVFEECER 337

  Fly   317 PVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAIL 381
            .|.:.|.||:::...|.|:::|||.:.|||::.:::::....::...:||.||...|||::.|:.
plant   338 LVVQCLRDARVNGGDIDDLIMVGGCSYIPKVRTIIKNVCKKDEIYKGVNPLEAAVRGAALEGAVT 402

  Fly   382 TGV----GSSQIQDLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQ 442
            :|:    ||   .|||.:...||::|:...|.....::.||..:|.::...|||..|||....|.
plant   403 SGIHDPFGS---LDLLTIQATPLAVGVRANGNKFIPVIPRNTMVPARKDLFFTTVQDNQKEALII 464

  Fly   443 VYEGERAMTKDNNLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKI----- 502
            :||||....::|:|||.|.|.||||||:|||:|.|..|::|...|.|.|.....|.|..:
plant   465 IYEGEGETVEENHLLGYFKLVGIPPAPKGVPEINVCMDIDASNALRVFAAVLMPGSSSPVVPVIE 529

  Fly   503 ----TISNDKGRLSKA 514
                |:.:..|..::|
plant   530 VRMPTVDDGHGWCAQA 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	170/536 (32%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	119/389 (31%)
HSP70T-2	NP_180771.1	HSP70_NBD	31..400	CDD:212667	117/385 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910