Protein Alignment Hsc70-2 and Hspa12a

DIOPT Version :9

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: XP_006527440.1
• Gene: Hspa12a / 73442
• MGIID: 1920692
• Length: 695
• Species: Mus musculus
• Alignment Length: 656
• Identity: 148/656 - (22%)
• Similarity: 231/656 - (35%)
• Gaps: 202/656 - (30%)

  Fly     7 IGIDLGTTYS-----------CVGV---WQNSKVEIIANDQG--NRTTPSYVAFNETERLIGDPA 55
            :.||.|||.|           |:.|   |:       ..|.|  |:.||:.:......:.
Mouse    79 VAIDFGTTSSGYAYSFTKEPECIHVMRRWE-------GGDPGVSNQKTPTTILLTPERKF----- 131

  Fly    56 KNQVAMNAKNTVFDAKRLIGRKFDDKKIQEDLKLWPFKV-INEKGKPKIEVEFKGER-KRFAPEE 118
             :.....|::...|        .|..:.::.|.|..||: ::..|...::.:..... |:....|
Mouse   132 -HSFGYAARDFYHD--------LDPSEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALE 187

  Fly   119 ISSMVLTKMREIAEVYL----GGKVKDA----VVTVPAYFNDSQRQATKDAGSIAGL------NV 169
            |.:..|...:|.|...|    |...:::    |:||||.:....:|..::|...|||      ..
Mouse   188 IFAYALQYFKEQALKELSDQAGSDFENSDVRWVITVPAIWKQPAKQFMREAAYQAGLASPENSEQ 252

  Fly   170 LRIINEPTAAAL--------------------AYG-------------------------LDKNL 189
            |.|..||.||::                    .|.                         |.:|:
Mouse   253 LIIALEPEAASIYCRKLRLHQMIELSSKAVVNGYSASDTVGAGFAQAKEHVRRNRQSRTFLVENV 317

  Fly   190 KGE--------RNVLIFDLGGGTFDVSV--LSIDEGSLFEV-KATAGDTHLGGED--FDNRLVNH 241
            .||        ...::.|.||||.|::|  :.:.||.|.|: |||.|.....|.|  |:..|...
Mouse   318 IGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLLCKI 382

  Fly   242 FAEEFKRKHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFE-- 304
            |.|:|..:.|  ||..| |...|..|.|..||..:......|.|......||:|.|......|
Mouse   383 FGEDFIEQFK--IKRPA-AWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHA 444

  Fly   305 --ELNMD-------------------LFRSTMQPVERALSD--AKMDKKAIHDVVLVGGSTRIPK 346
              :.|:|                   ||:.|:..:...|.|  .|.:...:..:.||||....|.
Mouse   445 LRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAEAPL 509

  Fly   347 IQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVDVAPLSLGIETAGGVM 411
            :|:.:|..||.| ..:.|..|..:   ..::.|:|.|:..:.|:    |..:||:.|:    ||:
Mouse   510 LQQAVQTAFGDK-CRIIIPQDVGL---TILKGAVLFGLDPAVIK----VRRSPLTYGV----GVL 562

  Fly   412 TNLVE----------RNARIPCKQ------------------QQIFTTYSDNQNAVTIQVYEGER 448
            ...||          ::....|..                  ::.:|....:|..:.|.:|..|.
Mouse   563 NRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIIINIYSSEH 627

  Fly   449 AMTKDN---------NLLGT--FNLTG----IPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGK 498
                ||         ...||  .:|||    ..||.|.:..| :.|   .|..:...|.|.:|.|
Mouse   628 ----DNVSFITDPGVKKCGTLRLDLTGSGGTAVPARREIQTI-MQF---GDTEIKATAVDITTSK 684

  Fly   499 SEKITI 504
            |.|:.|
Mouse   685 SVKVGI 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	148/656 (23%)
		HSPA1-2_6-8-like_NBD	6..382	CDD:212675	111/489 (23%)
Hspa12a	XP_006527440.1	HSPA12A_like_NBD	77..543	CDD:212685	112/491 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810