DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and hspa8

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_001103873.1	Gene:	hspa8 / 573376	ZFINID:	ZDB-GENE-990415-92	Length:	649	Species:	Danio rerio

Alignment Length:	650	Identity:	459/650 - (70%)
Similarity:	533/650 - (82%)	Gaps:	19/650 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKIPAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKN 65
            |.|.||:|||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||..|
Zfish     1 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65

  Fly    66 TVFDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREI 130
            |||||||||||:|||..:|.|:|.|||.|||:..:||::||:|||.|.|.||||||||||||:||
Zfish    66 TVFDAKRLIGRRFDDGVVQSDMKHWPFNVINDNSRPKVQVEYKGESKSFYPEEISSMVLTKMKEI 130

  Fly   131 AEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNV 195
            ||.|||..|.:||:||||||||||||||||||:|:|||||||||||||||:||||||.:..||||
Zfish   131 AEAYLGKTVSNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195

  Fly   196 LIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARA 260
            |||||||||||||:|:|::| :||||:|||||||||||||||:||||..|||||||.||..|.||
Zfish   196 LIFDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVNHFITEFKRKHKKDISDNKRA 259

  Fly   261 LRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDA 325
            :||||||||||||||||||:||:|||:|:||||||:.|:||||||||.||||.|:.|||:||.||
Zfish   260 VRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDA 324

  Fly   326 KMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQ 390
            ||||..|||:||||||||||||||||||.|.||:||.|||||||||||||||||||:|..|..:|
Zfish   325 KMDKAQIHDIVLVGGSTRIPKIQKLLQDYFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQ 389

  Fly   391 DLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNN 455
            ||||:||.||||||||||||||.|::||..||.||.|.||||||||..|.|||||||||||||||
Zfish   390 DLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454

  Fly   456 LLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRML 520
            |||.|.||||||||||||||||.||::|:||:||:|.|.||||..||||:||||||||.:|:||:
Zfish   455 LLGKFELTGIPPAPRGVPQIEVTFDIDANGIMNVSAVDKSTGKENKITITNDKGRLSKEDIERMV 519

  Fly   521 SEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP-SGVLSETERSKVRDKCSSEASWLDKN 584
            .||||||.|||.||::|.:||.||:|.:..:..|:|.. .|.:|:.::.|:.|||:....|||||
Zfish   520 QEAEKYKAEDDVQRDKVSAKNGLESYAFNMKSTVEDEKLKGKISDEDKQKILDKCNEVIGWLDKN 584

  Fly   585 SLAEKEEFESHLKECQRICTPIMSKIH---------------GGKKGKSSM--GKGSHPTVEEVD 632
            ..||:||||...||.:::|.||::|::               ||..|..:.  |..|.||:||||
Zfish   585 QTAEREEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPEGMPGGFPGAGAAPGGGSSGPTIEEVD 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	457/648 (71%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	299/375 (80%)
hspa8	NP_001103873.1	HSP70	1..614	CDD:331774	448/613 (73%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		303/384 (79%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		88/114 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..649		9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730