DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and hspa14

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_001038541.1	Gene:	hspa14 / 565232	ZFINID:	ZDB-GENE-041210-73	Length:	504	Species:	Danio rerio

Alignment Length:	510	Identity:	184/510 - (36%)
Similarity:	293/510 - (57%)	Gaps:	26/510 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70
            |||:..|.|.:||.|:::.:.:::|||.|:|.||:.||:.:||:::|..||.....||.|||...
Zfish     3 AIGVHFGYTCACVAVFKDGRADVVANDAGDRVTPAVVAYRDTEQIVGIAAKQGRIRNAANTVVKV 67

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            |:::||::||...|...:.....|:|:.|.|:.|::.....|..:||:::.::..||:|.|:..|
Zfish    68 KQILGRRYDDPDAQAHKEESKCIVVNKSGLPRYEIDTGETTKYVSPEDVAKLIFHKMKETAQSAL 132

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAY--GLDKNLKGERNVLIF 198
            |..|||||:|||..|::.|:.|.:.|...||.||||:|:||:||.|||  |.|..| |:.:||::
Zfish   133 GSDVKDAVITVPFEFDEMQKNALRQAAESAGFNVLRLIHEPSAALLAYDIGQDSPL-GKSHVLVY 196

  Fly   199 DLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRR 263
            .|||.:..|:||.::.| ::.|.||..|...|||.|...|..|.|.|||:..|.|:.|||||:.:
Zfish   197 KLGGTSLSVTVLEVNSG-VYRVLATQTDHQTGGESFTQELAQHLAAEFKKTFKQDVSGNARAMMK 260

  Fly   264 LRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMD 328
            |..:.:.||.|||:...|:..:|:|::|:||...:||||||.:...||...:||::..|....:.
Zfish   261 LMNSADVAKHTLSTLGSANCFVDSLYDGMDFECNVSRARFELICSSLFNKCIQPIKSLLEQVNLS 325

  Fly   329 KKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQI-QDL 392
            ...::.|||.|||.||||:|::::|||...:|..||.|||.:..|||:||.||.|..|..: :|.
Zfish   326 TSDVNKVVLSGGSARIPKLQQMIRDLFPDVELLNSIPPDEVIPVGAAMQAGILVGKDSLALGEDS 390

  Fly   393 LLVDVAPLSL--------GIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERA 449
            :.||.....:        |:|    |.|.|......:|.::|..... ..:.::|.:|:::.::.
Zfish   391 ITVDCCASDITLKEVDDSGLE----VFTVLFPSGTPLPARRQHTLQG-PGSLSSVRLQLFQAQQP 450

  Fly   450 MTKDNNLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITI 504
            :.:       ..|..:.|... :..:.....:..||.|:|...:.|:|:||.|||
Zfish   451 IAQ-------IVLGDLEPKEE-LHDVVTVLTMKRDGSLHVTCTEQSSGRSEAITI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	184/510 (36%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	156/377 (41%)
hspa14	NP_001038541.1	HSPA14-like_NBD	2..376	CDD:212680	154/374 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810