DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and HSPA14

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_057383.2	Gene:	HSPA14 / 51182	HGNCID:	29526	Length:	509	Species:	Homo sapiens

Alignment Length:	505	Identity:	178/505 - (35%)
Similarity:	286/505 - (56%)	Gaps:	8/505 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70
            |||:.||.|.:||.|:::.:..::|||.|:|.||:.||::|.|.::|..||.....|..|||...
Human     3 AIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVMKV 67

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            |:::||...|.:.|:.:......||.:.||.:.|::...|.|...||:::.::.:||:|.|...|
Human    68 KQILGRSSSDPQAQKYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAHSVL 132

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNL-KGERNVLIFD 199
            |....|.|:|||..|.:.|:.|..:|...||.||||:|:||:||.||||:.::. .|:.|:|:|.
Human   133 GSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFK 197

  Fly   200 LGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRL 264
            |||.:..:||:.::.| ::.|.:|..|.::||..|...|..:.|.||:|..|.|::|||||:.:|
Human   198 LGGTSLSLSVMEVNSG-IYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMMKL 261

  Fly   265 RTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDK 329
            ..:.|.||.:||:...|:..:|:|:||.||...:||||||.|...||...::.:...|.......
Human   262 TNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTA 326

  Fly   330 KAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLL 394
            ..|:.|||.|||:||||:|:|::|||...:|..||.|||.:..|||::|.||.|..:..::|.|:
Human   327 DDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLM 391

  Fly   395 VDVAP---LSLGIETAGGV-MTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGE-RAMTKDN 454
            ::.:.   |..|::.:|.. .|.|......:|.::|..... ..:.::|.:::||.: :...|:.
Human   392 IECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQA-PGSISSVCLELYESDGKNSAKEE 455

  Fly   455 NLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITI 504
            .......|..:.....|:..|.....:..||.|:|...|..|||.|.|:|
Human   456 TKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	178/505 (35%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	149/376 (40%)
HSPA14	NP_057383.2	HSPA14-like_NBD	2..376	CDD:212680	147/373 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1413
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.760