Protein Alignment Hsc70-2 and Hsp110

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001189103.1
• Gene: Hsp110 / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 709
• Identity: 200/709 - (28%)
• Similarity: 346/709 - (48%)
• Gaps: 113/709 - (15%)

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            ||||.|.....|...::..:|.:|||...|.|||:|||:..:|:||..||||...|.||||...|
  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68

  Fly    72 RLIGRKFDDKKIQEDLKLWPFKV-INEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            ||:||||:|..:|.:|...|.:| ....|...|:|.:.||.:.|.||::::|:.||::|.:...:
  Fly    69 RLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAM 133

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGE---RNVLI 197
            ..:|.|.|:..|.:|.:::|:|..||..||||||||::||.||.|||||..||...|   |||:.
  Fly   134 QTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIF 198

  Fly   198 FDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALR 262
            .|.|..:...|..:..:|.| ::.|:..| .:||.|.|..|.::||:||:.::|.:.|.||||..
  Fly   199 VDFGHSSLQASACAFTKGKL-KMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANL 261

  Fly   263 RLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAK 326
            ||.|..|:.|:.:| :||:..|.|:...:.||..|.:.|::.|||...:.:...|..:|.|:::|
  Fly   262 RLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESK 326

  Fly   327 MDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQD 391
            :....||.|.:||||:|||.:::|::.:| .|..:.::|.||||:.|||:|.||::  .:.::::
  Fly   327 LQLDDIHSVEIVGGSSRIPSVKQLIEQVF-NKPASTTLNQDEAVSRGAALQCAIMS--PAVRVRE 388

  Fly   392 LLLVDVAPLSLGI--ETAGGVMTNLVERNARIPCKQQQIFTTYS----------DNQNAVTIQVY 444
            ..:.|:...::.:  ::.|......:|           ||..|.          :.:....:.:.
  Fly   389 FGVTDIQNYAVKVLWDSEGSAAPGEIE-----------IFPQYHASPFSRLLTINRKGPFNVSIV 442

  Fly   445 EGERAMTKDNNLLGTFNLTGIPPAPRGVPQ-IEVAFDLNADGILNV------------------- 489
            .|::....|.. :|.:.:..:.|..||..| :::...:|.:||:.:
  Fly   443 YGQQVPYPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAE 506

  Fly   490 ----------------------------NAKDNST---------GKSEKI-----TISNDKGRLS 512
                                        |..||:|         |.::::     :.::.|.:.|
  Fly   507 QAASEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKAS 571

  Fly   513 KA---------------EIDRMLSEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP-SGV 561
            ||               ::.....:..|....|.::.||:.:||.||.::|..|..:...| ...
  Fly   572 KATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERY 636

  Fly   562 LSETERSKVRDKCSSEASWL-DKNSLAEKEEFESHLKECQRICTPIMSKIHGGKKGKSS 619
            :.|.||.|:..:.:...:|| :.....|::.:.|.|:...:...||..:....::|.::
  Fly   637 VVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAA 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	200/709 (28%)
Hsp110	NP_001189103.1	ASKHA_NBD_HSP70_HSPA4_like	4..378	CDD:466826	150/376 (40%)