DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and CG7182

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	145/516 - (28%)
Similarity:	246/516 - (47%)	Gaps:	51/516 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PAIGIDLGTTYSCVG-VWQNSKVEIIANDQGNRTTPSYVAFNETERL-IGDPAKNQVAMNAKNTV 67
            |..||.:|.:..|:. |..:.|.|:|||.||:|.:.:.:.::....: .|..||.::|...:..|
  Fly     3 PRFGIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAV 67

  Fly    68 FDAKRLIGRK--FDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERK----RFAPEEISSMVLTK 126
            ..:.:|:..|  ..::|:...|:..|.....|:...::|.....:|:    |...:::|:..:|.
  Fly    68 AHSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDREDQDDRVVTKDLSAYQVTV 132

  Fly   127 MREIAEVYL-------GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYG 184
            ....||:.|       |.:...||:::|:|:..|..:...||...||.:|.:||.|||||.|.|.
  Fly   133 ELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAVLGYS 197

  Fly   185 L-DKNLKGERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKR 248
            : ::..:..|:||....||...|::..|:..| ||...||.|...:||..|...||....|||:|
  Fly   198 IGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNG-LFVQLATFGPFPIGGRQFTEALVQFICEEFRR 261

  Fly   249 KHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRS 313
            |:|.|...:.|::.::|||....|..|::.....|.||:|.:|:|:.:::||||||.|...:..:
  Fly   262 KYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMSRARFESLIQPVINN 326

  Fly   314 TMQPVERALSDAKMDK---KAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAA 375
            .:|.:...:..|:.:.   ..|.|:||:|.:.:|||:|..:...|...:|:.|.:.||.||.|.|
  Fly   327 LIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSADEVVAIGCA 391

  Fly   376 VQAAILTGVGSSQI---------QDLLLV------DVAPLSLGIETAGGVMTNLVERNARIPCKQ 425
            .||..|......|:         :|.|.:      ..|.|.||   .|.|:...:    ||...|
  Fly   392 RQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLG---RGSVLPAKI----RISLPQ 449

  Fly   426 QQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTFNLTGIPPAPRGVPQIEVAFDL-NADG 485
            .:.......::.|.:.::..||      :.:|.....:.||  ..|:.|:||..|: :.||
  Fly   450 SEEGKGDDVSKAAASFKLRTGE------SEILARLPDSTIP--EDGLYQLEVEVDVDDKDG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	145/516 (28%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	118/394 (30%)
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	116/389 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840