DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-2 and hspa4a

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_999881.1	Gene:	hspa4a / 335865	ZFINID:	ZDB-GENE-040426-2832	Length:	833	Species:	Danio rerio

Alignment Length:	700	Identity:	205/700 - (29%)
Similarity:	338/700 - (48%)	Gaps:	111/700 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            :|.|:|.....|.|.:...:|.:||:..:|.|||:|:|....|.||..||:||..|.||||...|
Zfish     4 VGFDVGFQSCYVAVARAGGIETVANEYSDRCTPSFVSFGPRNRSIGAAAKSQVVTNCKNTVQGFK 68

  Fly    72 RLIGRKFDDKKIQE-------DLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMRE 129
            |..||.|.|..::.       ||...|      .|...|:|.:..|.|.|..|::::|:|||::|
Zfish    69 RFHGRAFSDPYVETTQSSLVYDLAQMP------NGTTGIKVMYMEEEKLFGIEQVTAMLLTKLKE 127

  Fly   130 IAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN-----L 189
            .||..|...|.|.|::||:||.|::|::..||..|||||.||::|:.||.|||||:.|.     .
Zfish   128 TAESALKKPVADCVISVPSYFTDAERRSVMDAAQIAGLNCLRLMNDTTAVALAYGIYKQDLPAPE 192

  Fly   190 KGERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDI 254
            :..|.|:..|:|...:.||..:.::|.| :|..:|.|..|||:|||..||.||.|||.:|:|.|:
Zfish   193 EKPRTVVFVDVGHAGYQVSACAFNKGKL-KVLGSAFDPELGGKDFDEVLVKHFCEEFAQKYKLDV 256

  Fly   255 KGNARALRRLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPV 318
            :...|||.||...||:.|:.:| :|::..|.|:.....||..||::||:||||...|......|:
Zfish   257 RSKPRALVRLYQECEKLKKLMSANSSDLPLNIECFMNDIDVSSKLNRAKFEELCAGLLAKVEAPL 321

  Fly   319 ERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTG 383
            :..:...::.|:.|:.|.::||::|||.|::.:...| ||:|:.::|.|||||.|.|:|.|||:
Zfish   322 QSIMEQTRLKKEDIYAVEIIGGASRIPAIKERISKFF-GKELSTTLNLDEAVARGCALQCAILS- 384

  Fly   384 VGSSQIQDLLLVDVAPLSLGIETAG----GVM-TNLVERNARIPCKQQQIFTTYSDNQNAVTIQV 443
             .:.::::..:.||.|..:.::...    ||. ..:..:|...|.  .::.|.|  .:...|::.
Zfish   385 -PAFKVREFSITDVVPYPISLKWTSAADEGVSDCEVFPKNHAAPF--SKVLTFY--RKEPFTLEA 444

  Fly   444 -YEGERAMTKDNNLLGTFNLTGIPPAPRG-VPQIEVAFDLNADGILNVNA--------------- 491
             |...:|:...:..:|.|.:..:.|...| ..:::|...:|..|:.:|::
Zfish   445 YYNNPKALPYPDPTIGQFTIHKVVPQASGESSKVKVKVRVNVHGVFSVSSASLVELLKPGEGEEP 509

  Fly   492 --------------------------------------KDNSTGKSEKITISND------KGRLS 512
                                                  :|..|...:|....||      |.::.
Zfish   510 METDTPAKDEENKMQVDQEAQKAQADDQKEQADKKSDTEDMETSPEDKQEKKNDQPPQAKKAKVK 574

  Fly   513 KAEID---------RMLSEA--------EKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSG 560
            ...:|         ::.|:|        .|..::|..::||..:||.:|.|:|..|..:......
Zfish   575 TKTVDLPIMNSLQWQLASDALNLFMENEGKMIMQDKLEKERNDAKNYVEEYVYEMRDKLHGVLEN 639

  Fly   561 VLSETERSKVRDKCSSEASWL-DKNSLAEKEEFESHLKECQRICTPIMSK 609
            .:||.||.....|.....:|| ::....:|:.:...|.|.:::..||.|:
Zfish   640 FVSEAERDSFSLKLEDTENWLYEEGEDQQKQVYIDKLAELKKLGDPIQSR 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	205/699 (29%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	152/387 (39%)
hspa4a	NP_999881.1	NBD_sugar-kinase_HSP70_actin	2..384	CDD:302596	152/387 (39%)
hspa4a	NP_999881.1	HSP70	3..692	CDD:278441	205/699 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810