Protein Alignment Hsc70-2 and hspa4a

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_999881.1
• Gene: hspa4a / 335865
• ZFINID: ZDB-GENE-040426-2832
• Length: 833
• Species: Danio rerio
• Alignment Length: 700
• Identity: 205/700 - (29%)
• Similarity: 338/700 - (48%)
• Gaps: 111/700 - (15%)

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            :|.|:|.....|.|.:...:|.:||:..:|.|||:|:|....|.||..||:||..|.||||...|
Zfish     4 VGFDVGFQSCYVAVARAGGIETVANEYSDRCTPSFVSFGPRNRSIGAAAKSQVVTNCKNTVQGFK 68

  Fly    72 RLIGRKFDDKKIQE-------DLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMRE 129
            |..||.|.|..::.       ||...|      .|...|:|.:..|.|.|..|::::|:|||::|
Zfish    69 RFHGRAFSDPYVETTQSSLVYDLAQMP------NGTTGIKVMYMEEEKLFGIEQVTAMLLTKLKE 127

  Fly   130 IAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN-----L 189
            .||..|...|.|.|::||:||.|::|::..||..|||||.||::|:.||.|||||:.|.     .
Zfish   128 TAESALKKPVADCVISVPSYFTDAERRSVMDAAQIAGLNCLRLMNDTTAVALAYGIYKQDLPAPE 192

  Fly   190 KGERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDI 254
            :..|.|:..|:|...:.||..:.::|.| :|..:|.|..|||:|||..||.||.|||.:|:|.|:
Zfish   193 EKPRTVVFVDVGHAGYQVSACAFNKGKL-KVLGSAFDPELGGKDFDEVLVKHFCEEFAQKYKLDV 256

  Fly   255 KGNARALRRLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPV 318
            :...|||.||...||:.|:.:| :|::..|.|:.....||..||::||:||||...|......|:
Zfish   257 RSKPRALVRLYQECEKLKKLMSANSSDLPLNIECFMNDIDVSSKLNRAKFEELCAGLLAKVEAPL 321

  Fly   319 ERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTG 383
            :..:...::.|:.|:.|.::||::|||.|::.:...| ||:|:.::|.|||||.|.|:|.|||:
Zfish   322 QSIMEQTRLKKEDIYAVEIIGGASRIPAIKERISKFF-GKELSTTLNLDEAVARGCALQCAILS- 384

  Fly   384 VGSSQIQDLLLVDVAPLSLGIETAG----GVM-TNLVERNARIPCKQQQIFTTYSDNQNAVTIQV 443
             .:.::::..:.||.|..:.::...    ||. ..:..:|...|.  .::.|.|  .:...|::.
Zfish   385 -PAFKVREFSITDVVPYPISLKWTSAADEGVSDCEVFPKNHAAPF--SKVLTFY--RKEPFTLEA 444

  Fly   444 -YEGERAMTKDNNLLGTFNLTGIPPAPRG-VPQIEVAFDLNADGILNVNA--------------- 491
             |...:|:...:..:|.|.:..:.|...| ..:::|...:|..|:.:|::
Zfish   445 YYNNPKALPYPDPTIGQFTIHKVVPQASGESSKVKVKVRVNVHGVFSVSSASLVELLKPGEGEEP 509

  Fly   492 --------------------------------------KDNSTGKSEKITISND------KGRLS 512
                                                  :|..|...:|....||      |.::.
Zfish   510 METDTPAKDEENKMQVDQEAQKAQADDQKEQADKKSDTEDMETSPEDKQEKKNDQPPQAKKAKVK 574

  Fly   513 KAEID---------RMLSEA--------EKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSG 560
            ...:|         ::.|:|        .|..::|..::||..:||.:|.|:|..|..:......
Zfish   575 TKTVDLPIMNSLQWQLASDALNLFMENEGKMIMQDKLEKERNDAKNYVEEYVYEMRDKLHGVLEN 639

  Fly   561 VLSETERSKVRDKCSSEASWL-DKNSLAEKEEFESHLKECQRICTPIMSK 609
            .:||.||.....|.....:|| ::....:|:.:...|.|.:::..||.|:
Zfish   640 FVSEAERDSFSLKLEDTENWLYEEGEDQQKQVYIDKLAELKKLGDPIQSR 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	205/699 (29%)
hspa4a	NP_999881.1	ASKHA_ATPase-like	2..382	CDD:483947	150/385 (39%)
		EzrA	<607..>751	CDD:428797	22/82 (27%)