DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-2 and hspa4b

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_956151.1	Gene:	hspa4b / 334086	ZFINID:	ZDB-GENE-030131-6018	Length:	840	Species:	Danio rerio

Alignment Length:	701	Identity:	198/701 - (28%)
Similarity:	334/701 - (47%)	Gaps:	112/701 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            :|.|:|.....|.|.:...:|.:||:..:|.||:.|:|....|.||..||:|:..|.||||...|
Zfish     4 VGFDVGFLNCYVAVARAGGIETVANEYSDRCTPACVSFGPRNRSIGAAAKSQMVTNCKNTVHGFK 68

  Fly    72 RLIGRKFDDKKIQE-------DLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMRE 129
            |..||.|.|..:|.       ||...|      .|...::|.:..|.|.|:.|::::|:|||::|
Zfish    69 RFHGRAFSDPFVQNLKPSLVYDLAQMP------SGTTGLKVMYMEEEKVFSIEQVTAMLLTKLKE 127

  Fly   130 IAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN-----L 189
            .||..|...|.|.|::||.::.|::|::..||..|||||.||::||.||.|||||:.|.     .
Zfish   128 TAESALKKPVADCVISVPCFYTDAERRSVIDAAQIAGLNCLRLMNETTAVALAYGIYKQDLPAPE 192

  Fly   190 KGERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDI 254
            :..|||:..|:|...:.|||.:.::|.| ::.|||.|..:||:.||.|||.:|.|||..|:|.|.
Zfish   193 EKPRNVVFVDIGHSGYQVSVCAFNKGKL-KILATAFDPEMGGKYFDERLVKYFCEEFVVKYKLDA 256

  Fly   255 KGNARALRRLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPV 318
            |...|||.||...||:.|:.:| :|::..|.|:.....:|..|:::||:|||:..|:......|:
Zfish   257 KTKPRALIRLFQECEKLKKLMSANSSDLPLNIECFMNDVDVSSRLNRAQFEEMCADILARVEPPL 321

  Fly   319 ERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTG 383
            ...|..|.:.|..||.|.:|||::|:|.|::.:...| ||:.:.::|.|||||.|.|:|.|||:
Zfish   322 RSLLEQAHLKKDDIHAVEIVGGASRMPAIKERISKFF-GKEPSTTLNADEAVARGCALQCAILS- 384

  Fly   384 VGSSQIQDLLLVDVAPLSLGIE----TAGGVM-TNLVERNARIPCKQQQIFTTYSDNQNAVTIQV 443
             .:.::::..:.:|.|..:.::    ...||. ..:..:|...|.  .::.|.|  .:...|:..
Zfish   385 -PAFKVREFSITEVVPFPISLKWNSAAEDGVSDCEVFPKNHAAPF--SKVLTFY--RREPFTLDA 444

  Fly   444 -YEGERAMTKDNNLLGTFNLTGIPPAPRG-VPQIEVAFDLNADGILNVNA-------KDNSTGKS 499
             |...:.:...:..:|.:.:..:.|...| ..:::|...:|..||.:|::       |.....:|
Zfish   445 YYNSPKELPYPDPTIGQYVVQKVVPQASGESSKVKVKVRVNIHGIFSVSSASLVEVQKSEEEEES 509

  Fly   500 EKITISNDKGRLSKAEIDR---------------------MLSEAEKYK---------------- 527
            .:...|.:|...:|.::|:                     |.:.||:.|
Zfish   510 METEQSTEKENENKMQVDQEEQKTPETEQENGEKKPGTEEMETSAEEGKQEKKSDQPPQAKKPKV 574

  Fly   528 ---------------------------------VEDDRQRERVQSKNNLEAYIYACRQAVDDAPS 559
                                             ::|..::||..:||.:|.|:|..|..:.....
Zfish   575 KTKVLDLPIENNPQWQLANDMLNLFVESEGKMIMQDKLEKERNDAKNYVEEYVYEMRDKLHGIFE 639

  Fly   560 GVLSETERSKVRDKCSSEASWLDKNSLAE-KEEFESHLKECQRICTPIMSK 609
            ..::|::|..:..|......||.::...: |:.:...|.|.:.:..||..:
Zfish   640 KFVTESDRDVLSLKLEDTEVWLYEDGEDQPKQIYIDKLAELKNLGQPIQDR 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	198/701 (28%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	150/387 (39%)
hspa4b	NP_956151.1	HSPA4_NBD	2..384	CDD:212687	150/387 (39%)
hspa4b	NP_956151.1	HSP70	3..693	CDD:278441	198/701 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810