DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-2 and HSPA9

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_004125.3	Gene:	HSPA9 / 3313	HGNCID:	5244	Length:	679	Species:	Homo sapiens

Alignment Length:	631	Identity:	295/631 - (46%)
Similarity:	410/631 - (64%)	Gaps:	32/631 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFN-ETERLIGDPAKNQVAMNAKNTVFDA 70
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||. :.|||:|.|||.|...|..||.:..
Human    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVIN-EKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVY 134
            ||||||::||.::|:|:|..|||::. ..|...:|    ...|.::|.:|.:.||.||:|.||.|
Human   121 KRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVE----AHGKLYSPSQIGAFVLMKMKETAENY 181

  Fly   135 LGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 199
            ||...|:||:||||||||||||||||||.|:||||||:|||||||||||||||:  .::.:.::|
Human   182 LGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVYD 244

  Fly   200 LGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRL 264
            |||||||:|:|.|.:| :||||:|.|||.|||||||..|:.|..:||||:...|:..:..||:|:
Human   245 LGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRV 308

  Fly   265 RTACERAKRTLSSSTEASLEIDAL--------HEGIDFYSKISRARFEELNMDLFRSTMQPVERA 321
            |.|.|:||..||||.:..:.:..|        |..:    |::||:||.:..||.|.|:.|.::|
Human   309 REAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNM----KLTRAQFEGIVTDLIRRTIAPCQKA 369

  Fly   322 LSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGS 386
            :.||::.|..|.:|:||||.||:||:|:.:|||| |:..:.::|||||||.|||:|..:|.|
Human   370 MQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAG--- 430

  Fly   387 SQIQDLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMT 451
             .:.|:||:||.||||||||.|||.|.|:.||..||.|:.|:|:|.:|.|..|.|:|.:|||.|.
Human   431 -DVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMA 494

  Fly   452 KDNNLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEI 516
            .||.|||.|.|.||||||||||||||.||::|:||::|:|||..||:.::|.|.: .|.|||.:|
Human   495 GDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDI 558

  Fly   517 DRMLSEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWL 581
            :.|:..||||..||.|::|||::.|..|..|:.....:::. ...|...|.:|::::.|.....|
Human   559 ENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEF-KDQLPADECNKLKEEISKMRELL 622

  Fly   582 DKNSLAEKEEFESHLKECQRICTPIM----SKIHGGKKGKSSMGKG 623
            .:......|.........|:....:.    .|:...::|..|.|.|
Human   623 ARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTG 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	295/631 (47%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	193/384 (50%)
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269\|PubMed:26702583	1..432		195/391 (50%)
		dnaK	52..673	CDD:234715	295/631 (47%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269\|PubMed:26702583	432..679		100/239 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..679		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820