Protein Alignment Hsc70-2 and HSPA6

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_002146.2
• Gene: HSPA6 / 3310
• HGNCID: 5239
• Length: 643
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 446/637 - (70%)
• Similarity: 529/637 - (83%)
• Gaps: 11/637 - (1%)

  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70
            |:|||||||||||||:|..:|||:|||||||||||||||.:||||:||.||:|.|:|..||||||
Human     8 AVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDA 72

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            ||||||||.|..:|.|:|.|||:|::|.||||:.|.::||.|.|.|||||||||:||:|.||.||
Human    73 KRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYL 137

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 200
            |..||.||:||||||||||||||||||:|||||||||||||||||:|||||:...||||||||||
Human   138 GQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDL 202

  Fly   201 GGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLR 265
            |||||||||||||.| :|||||||||||||||||||||||||.|||:|||..|:.||.|||||||
Human   203 GGGTFDVSVLSIDAG-VFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLR 266

  Fly   266 TACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKK 330
            ||||||||||||||:|:||||:|.||:|||:.|:|||||||..||||||::|||:||.|||:||.
Human   267 TACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKA 331

  Fly   331 AIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLV 395
            .|||||||||||||||:||||||.|.||:||.|||||||||||||||||:|.|....::|||||:
Human   332 QIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLL 396

  Fly   396 DVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTF 460
            ||||||||:||||||||.|::|||.||.||.|.||||||||..|.||||||||||||||||||.|
Human   397 DVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRF 461

  Fly   461 NLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAEK 525
            .|:||||||||||||||.||::|:|||:|.|.|.||||:.||||:||||||||.|::||:.|||:
Human   462 ELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAEQ 526

  Fly   526 YKVEDDRQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKNSLAEK 589
            ||.||:.||:||.:||:|||:::..:.:: :::....:.|.:|.|::|||....:||:.|.||||
Human   527 YKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEK 591

  Fly   590 EEFESHLKECQRICTPIMSKIHGGK--KGKSSMG-------KGSHPTVEEVD 632
            ||:|...:|.::||.||.|:::||.  .|.||.|       ..:.|.:||||
Human   592 EEYEHQKRELEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPSTGPIIEEVD 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	444/635 (70%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		296/380 (78%)
		PTZ00009	8..643	CDD:240227	444/635 (70%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		88/114 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..643		7/26 (27%)