Protein Alignment Hsc70-2 and HSPA2

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 459/635 - (72%)
• Similarity: 537/635 - (84%)
• Gaps: 8/635 - (1%)

  Fly     5 PAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFD 69
            ||||||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||..||:||
Human     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    70 AKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVY 134
            |||||||||:|..:|.|:|.|||:|::|.||||::||:|||.|.|.||||||||||||:||||.|
Human    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   135 LGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN--LKGERNVLI 197
            |||||..||:||||||||||||||||||:|.|||||||||||||||:||||||.  ..||:||||
Human   136 LGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   198 FDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALR 262
            |||||||||||:|:|::| :||||:|||||||||||||||:|:|.|||||||||.||..|.||:|
Human   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264

  Fly   263 RLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKM 327
            |||||||||||||||||:||:|||:|:||:|||:.|:||||||||.||||.|::|||:||.|||:
Human   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329

  Fly   328 DKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDL 392
            ||..|.::||||||||||||||||||.|.||:||.|||||||||||||||||||.|..|..:|||
Human   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394

  Fly   393 LLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLL 457
            ||:||.||||||||||||||.|::||..||.||.|.||||||||::|.:||||||||||||||||
Human   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459

  Fly   458 GTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSE 522
            |.|:||||||||||||||||.||::|:|||||.|.|.||||..||||:||||||||.:||||:.|
Human   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524

  Fly   523 AEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP-SGVLSETERSKVRDKCSSEASWLDKNSL 586
            ||:||.||:..|:||.:||.||:|.|..:|.|:|.. .|.:||.:::|:.|||....:|||:|.:
Human   525 AERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589

  Fly   587 AEKEEFESHLKECQRICTPIMSKIHGGKKGKSSMGKGS----HPTVEEVD 632
            |||:|:|...||.:|:|.||:||::.|..|..|.|.||    .||:||||
Human   590 AEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	457/633 (72%)
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	447/609 (73%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		301/383 (79%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		88/114 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		10/25 (40%)