Protein Alignment Hsc70-2 and hyou1

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_997868.1
• Gene: hyou1 / 327133
• ZFINID: ZDB-GENE-030131-5344
• Length: 980
• Species: Danio rerio
• Alignment Length: 784
• Identity: 202/784 - (25%)
• Similarity: 350/784 - (44%)
• Gaps: 182/784 - (23%)

  Fly     4 IPAIGIDLGTTYSCVGVWQ-NSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTV 67
            :..:.:|||:.:..|.:.: ...:||:.|.:..|.||..|...|.|||.||.|......|.|...
Zfish    25 VAVMSVDLGSEWMKVAIVKPGVPMEIVLNKESRRKTPVAVCLKENERLFGDGALGVAVKNPKVVY 89

  Fly    68 FDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFK-GERKRFAPEEISSMVLTKMREIA 131
            ...:.::|:..|:.::.|..|.:|...: :|.:.:..|.|| .|..::.|||:..|:|...|.:|
Zfish    90 RFLQSILGKTADNPQVAEYQKHFPEHQL-QKDEKRGTVYFKFSEEMQYTPEELLGMILNYSRTLA 153

  Fly   132 EVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGL----DKNLKGE 192
            :.:....:||||:|||||||.::|:|...|..||||.||::||:.||.||.||:    |.|...:
Zfish   154 QDFAEQPIKDAVITVPAYFNQAERRAVLQAAHIAGLKVLQLINDNTAVALNYGVFRRKDINSTAQ 218

  Fly   193 RNVLIFDLGGGTFDVSVLSI------DEGS--LFEVKATAGDTHLGGEDFDNRLVNHFAEEF--K 247
             |::.:|:|.|:...::::.      :.|:  ..:::....|..|||.:.:.||.:|.|:.|  :
Zfish   219 -NIMFYDMGSGSTTATIVTYQTVKTKESGTQPQLQIRGVGFDRTLGGFEMELRLRDHLAKLFNEQ 282

  Fly   248 RKHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFR 312
            :|.|.|::.|.||:.:|....:|.|..||::.|.:.:|:.|.:.|||.:|::|:.||.|..|||.
Zfish   283 KKSKKDVRDNLRAMAKLLKEAQRLKTVLSANAEHTAQIEGLMDDIDFKAKVTRSEFEALCEDLFD 347

  Fly   313 STMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQ 377
            ....||::||:.|:|....|..|:||||:||:||:|.:|....|.::|:.:||.|||.|.||..|
Zfish   348 RVPGPVKQALAAAEMSMDEIEQVILVGGATRVPKVQDVLLKSVGKEELSKNINADEAAAMGAVYQ 412

  Fly   378 AAILTGVGSSQIQDLLLVDVAPLSLGIETA------GGVMTNLVERNARI------PCKQQQIFT 430
            ||.|:  .:.:::..|:.|.|...:.:|.:      .||.:  ::.|.||      |..|:::.|
Zfish   413 AAALS--KAFKVKPFLVRDAAVFPIQVEFSRETEEEDGVKS--LKHNKRILFQRMAPYPQRKVIT 473

  Fly   431 ------------TYSD-------------NQNAVTIQV--------------------------- 443
                        .|.|             :||..|:::
Zfish   474 FNRYIDDFVFYINYGDLSFLSEQDMKVFGSQNLTTVKLSGVGSSFKKHSDAESKGIKAHFNMDES 538

  Fly   444 ------------------YEGERAMTKDNNLLGTF----------NLT----------------- 463
                              .|.|..:||..|.:.:.          |:|
Zfish   539 GVLILDRVESVFETIVEEKEEESTLTKLGNTISSLFGGGSSEPSANVTEPVTDEEEVTPEAGKEQ 603

  Fly   464 ------------------GIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISND--- 507
                              |....|:...|.|........|    ..:...|.|.|:.|...:
Zfish   604 DQPEKQEETVQEKPETEEGKEAEPQAEEQKEDKEKAENQG----ETESEKTEKPEEKTTDEEKEA 664

  Fly   508 --------KGRLS-----KAEIDRMLS------EAEKYKVED--DR---QRERVQSKNNLEAYIY 548
                    |.::|     :.|::.:|.      |..|.|::|  ||   ::||.::.|:|||:|:
Zfish   665 DMKPKLQKKSKISADIAVELEVNDVLDPSAEDMEGSKKKLQDLTDRDLEKQEREKTLNSLEAFIF 729

  Fly   549 ACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKNSL-AEKEEFESHLKECQRICTPIMSKIH 611
            ..:..: .|....|::|.|:.::..:.|..:||:|:... |..:..:..|.|.:::|..:..::.
Zfish   730 ETQDKLYQDEYQAVVTEEEKEQISGRLSVASSWMDEEGYRAGTKLLKEKLSELKKLCKGMFFRVE 794

  Fly   612 GGKK 615
            ..||
Zfish   795 ERKK 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	202/784 (26%)
hyou1	NP_997868.1	ASKHA_NBD_HSP70_HYOU1	26..414	CDD:466828	135/389 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	558..682		18/127 (14%)
		PTZ00121	<592..973	CDD:173412	40/211 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	894..980
		Prevents secretion from ER. /evidence=ECO:0000255	977..980