Protein Alignment Hsc70-2 and Hspa12b

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001381945.1
• Gene: Hspa12b / 311427
• RGDID: 1312004
• Length: 685
• Species: Rattus norvegicus
• Alignment Length: 654
• Identity: 151/654 - (23%)
• Similarity: 234/654 - (35%)
• Gaps: 212/654 - (32%)

  Fly    28 IIANDQGNRTTPSYVAFN-----ETERLI-----GDPAKNQVAMNAKNT--------VFDAKRLI 74
            ::|.|.|  ||.|..||:     |...::     |||.   ||.....|        :|.:....
  Rat    62 VVAIDFG--TTSSGYAFSFATDPEAIHMMRKWEGGDPG---VAHQKTPTCLLLTPEGIFHSFGYT 121

  Fly    75 GRKF----DDKKIQEDLKLWPFKV----------------INEKGKPKIEVEFKGERKRFAPEEI 119
            .|.:    |.::.::.|....||:                :|  ||..:.:|......||..|.
  Rat   122 ARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVN--GKKMLALEVFAHALRFFKEH- 183

  Fly   120 SSMVLTKMREIAEVYLGGKVKDA---VVTVPAYFNDSQRQATKDAGSIAGL------NVLRIINE 175
               .|.::||.:|..|   .|||   |:||||.:....:|..::|..:|||      ..|.|..|
  Rat   184 ---ALQELREQSECML---EKDAVRWVLTVPAIWKQPAKQFMREAAYLAGLVSREDAEKLLIALE 242

  Fly   176 PTAAAL-----------------AYG--------LDKNLKGERNVL------------------- 196
            |.||::                 |.|        :|.:.:..|..|
  Rat   243 PEAASVYCRKLRLHQLMDLSSRTAGGGRLGERRSIDSSFRHAREQLRRSRHSRTFLVESGVGELW 307

  Fly   197 ----------IFDLGGGTFDVSVLSIDE--GSLFEV-KATAGDTHLGGED--FDNRLVNHFAEEF 246
                      :.|.||||.|::|..:::  |:|.|: ||:.|.....|.|  |:..|...|.|:|
  Rat   308 SEMQEGDRYMVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDF 372

  Fly   247 KRKHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSK-------------- 297
            ..|.|   :....|...|..|.|..|||.......:|.|......||||.|
  Rat   373 IAKFK---RQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSS 434

  Fly   298 ----------ISRARFEELNMDLFRST----MQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQ 348
                      :.|...|.:| :||:.|    :|.:|..|  ||.:.:.:..:.||||......:|
  Rat   435 VNFVKWSSQGMLRMSCEAMN-ELFQPTVSGIIQHIEMLL--AKPEVQGVKLLFLVGGFAESAVLQ 496

  Fly   349 KLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVDVAPLSLGIETAGGVMT- 412
            ..:|:..|.:.|.:.:..|..:   ..::.|:|.|    |...::.|..:||:.|:    ||:.
  Rat   497 HAVQEALGNRGLRVVVPHDVGL---TILKGAVLFG----QAPGVVRVRRSPLTYGV----GVLNR 550

  Fly   413 ---------NLVERNARIPCKQ---------------QQIFTTY---SDNQNAVTIQVY----EG 446
                     .|:.|:.|..|..               :::..:|   ...|..|.|.:|    |.
  Rat   551 FVPGHHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAED 615

  Fly   447 ERAMTKDN-NLLGTFNL----------TGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSE 500
            .|.:|... ...|..:|          ||..|:.|   :|..|... .|..:.|.|.|.||.:|.
  Rat   616 ARFITDPGVRKCGALSLELEPEGSPENTGTSPSRR---EIRAAMQF-GDTEIKVTAVDVSTNRSV 676

  Fly   501 KITI 504
            :..|
  Rat   677 RAAI 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	151/654 (23%)
Hspa12b	NP_001381945.1	ASKHA_ATPase-like	61..528	CDD:483947	115/488 (24%)