Protein Alignment Hsc70-2 and Hspa12a

DIOPT Version :9

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: XP_017444569.1
• Gene: Hspa12a / 307997
• RGDID: 1305531
• Length: 691
• Species: Rattus norvegicus
• Alignment Length: 652
• Identity: 147/652 - (22%)
• Similarity: 232/652 - (35%)
• Gaps: 194/652 - (29%)

  Fly     7 IGIDLGTTYS-----------CVGV---WQNSKVEIIANDQG--NRTTPSYVAFNETERLIGDPA 55
            :.||.|||.|           |:.|   |:       ..|.|  |:.||:.:......:.
  Rat    75 VAIDFGTTSSGYAYSFTKEPECIHVMRRWE-------GGDPGVSNQKTPTTILLTPERKF----- 127

  Fly    56 KNQVAMNAKNTVFDAKRLIGRKFDDKKIQEDLKLWPFKV-INEKGKPKIEVEFKGER-KRFAPEE 118
             :.....|::...|        .|..:.::.|.|..||: ::..|...::.:..... |:....|
  Rat   128 -HSFGYAARDFYHD--------LDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALE 183

  Fly   119 ISSMVLTKMREIAEVYL----GGKVKDA----VVTVPAYFNDSQRQATKDAGSIAGL------NV 169
            |.:..|...:|.|...|    |...:::    |:||||.:....:|..::|...|||      ..
  Rat   184 IFTYALQYFKEQALKELSDQAGSDFENSDVRWVITVPAIWKQPAKQFMREAAYQAGLASPENSEQ 248

  Fly   170 LRIINEPTAAAL--------------------AYG-------------------------LDKNL 189
            |.|..||.||::                    .|.                         |.:|:
  Rat   249 LIIALEPEAASIYCRKLRLHQMIELSSKAVVNGYSASDTVGAGFAQAKEHVRRNRQSRTFLVENV 313

  Fly   190 KGE--------RNVLIFDLGGGTFDVSV--LSIDEGSLFEV-KATAGDTHLGGED--FDNRLVNH 241
            .||        ...::.|.||||.|::|  :.:.||.|.|: |||.|.....|.|  |:..|...
  Rat   314 IGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLLCKI 378

  Fly   242 FAEEFKRKHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFE-- 304
            |.|:|..:.|  ||..| |...|..|.|..||..:......|.|......||:|.|......|
  Rat   379 FGEDFIEQFK--IKRPA-AWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHA 440

  Fly   305 --ELNMD-------------------LFRSTMQPVERALSD--AKMDKKAIHDVVLVGGSTRIPK 346
              :.|:|                   ||:.|:..:...|.|  .|.:...:..:.||||....|.
  Rat   441 LRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAEAPL 505

  Fly   347 IQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVDVAPLSLGIETAGGVM 411
            :|:.:|..||.| ..:.|..|..:   ..::.|:|.|:..:.|:    |..:||:.|:    ||:
  Rat   506 LQQAVQAAFGDK-CRIIIPQDVGL---TILKGAVLFGLDPAVIK----VRRSPLTYGV----GVL 558

  Fly   412 TNLVE----------RNARIPCKQ------------------QQIFTTYSDNQNAVTIQVYEGER 448
            ...||          ::....|..                  ::.:|....:|..:.|.:|..|.
  Rat   559 NRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIIINIYSSEN 623

  Fly   449 ---AMTKDNNL--LGT--FNLTGIP----PAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKI 502
               :...|..:  .||  .:|||..    ||.|.: |..:.|   .|..:...|.|.:|.||.|:
  Rat   624 DDVSFITDPGVKKCGTLRLDLTGTSGAAVPARREI-QTLMQF---GDTEIKATAVDIATSKSVKV 684

  Fly   503 TI 504
            .|
  Rat   685 GI 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	147/652 (23%)
		HSPA1-2_6-8-like_NBD	6..382	CDD:212675	111/489 (23%)
Hspa12a	XP_017444569.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810