Protein Alignment Hsc70-2 and Hspa9

DIOPT Version :9

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001094128.2
• Gene: Hspa9 / 291671
• RGDID: 1311806
• Length: 679
• Species: Rattus norvegicus
• Alignment Length: 634
• Identity: 295/634 - (46%)
• Similarity: 409/634 - (64%)
• Gaps: 29/634 - (4%)

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFN-ETERLIGDPAKNQVAMNAKNTVFDA 70
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||. :.|||:|.|||.|...|..||.:..
  Rat    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTPDGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVIN-EKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVY 134
            ||||||::||.::|:|.|..|||::. ..|...:|    ...|.::|.:|.:.||.||:|.||.|
  Rat   121 KRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVE----AHGKLYSPSQIGAFVLMKMKETAENY 181

  Fly   135 LGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 199
            ||...|:||:||||||||||||||||||.|:||||||:|||||||||||||||:  .::.:.::|
  Rat   182 LGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVYD 244

  Fly   200 LGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRL 264
            |||||||:|:|.|.:| :||||:|.|||.|||||||..|:.|..:||||:...|:..:..||:|:
  Rat   245 LGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRV 308

  Fly   265 RTACERAKRTLSSSTEASLEIDAL--------HEGIDFYSKISRARFEELNMDLFRSTMQPVERA 321
            |.|.|:||..||||.:..:.:..|        |..:    |::||:||.:..||.:.|:.|.::|
  Rat   309 REAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNM----KLTRAQFEGIVTDLIKRTIAPCQKA 369

  Fly   322 LSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGS 386
            :.||::.|..|.:|:||||.||:||:|:.:|||| |:..:.::|||||||.|||:|..:|.|
  Rat   370 MQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAG--- 430

  Fly   387 SQIQDLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMT 451
             .:.|:||:||.||||||||.|||.|.|:.||..||.|:.|:|:|.:|.|..|.|:|.:|||.|.
  Rat   431 -DVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMA 494

  Fly   452 KDNNLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEI 516
            .||.|||.|.|.||||||||||||||.||::|:||::|:|||..||:.::|.|.: .|.|||.:|
  Rat   495 GDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDI 558

  Fly   517 DRMLSEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWL 581
            :.|:..||||..||.|::|||::.|..|..|:.....:::. ...|...|.:|::::.|.....|
  Rat   559 ENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEF-KDQLPADECNKLKEEISKMRELL 622

  Fly   582 DKNSLAEKEEFESHLKECQRICTPIMSKIHGGKKGKSSMGKGSHPTVEE 630
            .:......|.........|:....:....: .|......|.||..|.|:
  Rat   623 ARKDSETGENIRQAASSLQQASLKLFEMAY-KKMASEREGSGSSSTGEQ 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	295/634 (47%)
		HSPA1-2_6-8-like_NBD	6..382	CDD:212675	192/384 (50%)
Hspa9	NP_001094128.2	Interaction with NFS1. /evidence=ECO:0000250|UniProtKB:P38646	1..432		194/391 (50%)
		dnaK	52..656	CDD:234715	290/618 (47%)
		HSPA9-like_NBD	52..428	CDD:212683	192/383 (50%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250|UniProtKB:P38646	432..679		101/242 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..679		5/16 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820