DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and SLC9C2

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	XP_011507728.1	Gene:	SLC9C2 / 284525	HGNCID:	28664	Length:	1129	Species:	Homo sapiens

Alignment Length:	434	Identity:	71/434 - (16%)
Similarity:	137/434 - (31%)	Gaps:	175/434 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAKRLIGRKFDDKKIQED 86
            |::..|::..:...|   ..|...:|::.|    :|.:|...||..|    |..|...||
Human   782 QDAVKELVLMEHEGR---DVVIALKTKQAI----RNVIAKALKNLTF----LCSRGIIDK----- 830

  Fly    87 LKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREI-----------AEVYLGGKV- 139
                 .:||                      ||:.::|.|::.:           .::||...:
Human   831 -----HEVI----------------------EINKVLLKKLKALNNFPKAIPPPTPDIYLHNIIW 868

  Fly   140 ---KDAVVTVPAYFNDSQRQATKDAGS---------------IAGLNVLRIINEPTAAALAYGLD 186
               ||.::.   :|.:..:.|..|:|.               |:|:.:|..:: ||     :|::
Human   869 LEGKDVLID---FFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAILHSLS-PT-----FGIE 924

  Fly   187 KNLKGERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHK 251
            .|.:.:|         |:.|          :|....|.||           ::...:...||:.:
Human   925 SNQRCDR---------GSRD----------MFTEFCTTGD-----------IIGELSCLLKREIE 959

  Fly   252 SDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGID----------------------F 294
            ..:            .||      :|.....:.::.|:||.|                      |
Human   960 YTV------------ICE------TSLQACFISLEDLYEGFDAFWPSLEYKIWLKLALSTAYQYF 1006

  Fly   295 YSKI--SRARFEELNMDLFRSTMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGG 357
            .|.:  ...||:  |..:|.........:.||..:|...:..|::|.||.
Human  1007 ESSLIDEDLRFQ--NCVMFNQAYVETLSSYSDMIIDNMTMKFVIIVYGSV--------------- 1054

  Fly   358 KQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVDVAPLS 401
                :....:|.......:........|:|.:..||::..:.|:
Human  1055 ----IDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLIIQASELT 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	71/434 (16%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	66/413 (16%)
SLC9C2	XP_011507728.1	Na_H_Exchanger	98..380	CDD:294713
		Ion_trans	638..>731	CDD:278921
		CAP_ED	873..980	CDD:237999	25/163 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900