Protein Alignment Hsc70-2 and HSPA12A

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001317093.1
• Gene: HSPA12A / 259217
• HGNCID: 19022
• Length: 692
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 147/656 - (22%)
• Similarity: 231/656 - (35%)
• Gaps: 202/656 - (30%)

  Fly     7 IGIDLGTTYS-----------CVGV---WQNSKVEIIANDQG--NRTTPSYVAFNETERLIGDPA 55
            :.:|.|||.|           |:.|   |:       ..|.|  |:.||:.:......:.
Human    76 VAVDFGTTSSGYAYSFTKEPECIHVMRRWE-------GGDPGVSNQKTPTTILLTPERKF----- 128

  Fly    56 KNQVAMNAKNTVFDAKRLIGRKFDDKKIQEDLKLWPFKV-INEKGKPKIEVEFKGER-KRFAPEE 118
             :.....|::...|        .|..:.::.|.|..||: ::..|...::.:..... |:....|
Human   129 -HSFGYAARDFYHD--------LDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALE 184

  Fly   119 ISSMVLTKMREIAEVYL----GGKVKDA----VVTVPAYFNDSQRQATKDAGSIAGL------NV 169
            |.:..|...:|.|...|    |.:.:::    |:||||.:....:|..:.|...|||      ..
Human   185 IFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLASPENSEQ 249

  Fly   170 LRIINEPTAAAL--------------------AYG-------------------------LDKNL 189
            |.|..||.||::                    .|.                         |.:|:
Human   250 LIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTFLVENV 314

  Fly   190 KGE--------RNVLIFDLGGGTFDVSV--LSIDEGSLFEV-KATAGDTHLGGED--FDNRLVNH 241
            .||        ...::.|.||||.|::|  :.:.||.|.|: |||.|.....|.|  |:..|...
Human   315 IGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLLYKI 379

  Fly   242 FAEEFKRKHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFE-- 304
            |.|:|..:.|  ||..| |...|..|.|..||..:......|.|......||:|.|......|
Human   380 FGEDFIEQFK--IKRPA-AWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHA 441

  Fly   305 --ELNMD-------------------LFRSTMQPVERALSD--AKMDKKAIHDVVLVGGSTRIPK 346
              :.|:|                   ||:.|:..:...|.|  .|.:...:..:.||||....|.
Human   442 LRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAEAPL 506

  Fly   347 IQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVDVAPLSLGIETAGGVM 411
            :|:.:|..| |.|..:.|..|..:   ..::.|:|.|:..:.|:    |..:||:.|:    ||:
Human   507 LQQAVQAAF-GDQCRIIIPQDVGL---TILKGAVLFGLDPAVIK----VRRSPLTYGV----GVL 559

  Fly   412 TNLVE----------RNARIPCKQ------------------QQIFTTYSDNQNAVTIQVYEGER 448
            ...||          ::....|..                  ::.:|....:|..:.|.:|..|.
Human   560 NRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIVINIYSSEH 624

  Fly   449 AMTKDN---------NLLGT--FNLTGIP----PAPRGVPQIEVAFDLNADGILNVNAKDNSTGK 498
                ||         ...||  .:|||..    ||.|.: |..:.|   .|..:...|.|.:|.|
Human   625 ----DNVSFITDPGVKKCGTLRLDLTGTSGTAVPARREI-QTLMQF---GDTEIKATAIDIATSK 681

  Fly   499 SEKITI 504
            |.|:.|
Human   682 SVKVGI 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	147/656 (22%)
HSPA12A	NP_001317093.1	ASKHA_NBD_HSP70_HSPA12A	74..540	CDD:466841	111/491 (23%)