DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-2 and HSPA12A

DIOPT Version :9

Sequence 1:NP_524339.1 Gene:Hsc70-2 / 41609 FlyBaseID:FBgn0001217 Length:633 Species:Drosophila melanogaster
Sequence 2:NP_001317093.1 Gene:HSPA12A / 259217 HGNCID:19022 Length:692 Species:Homo sapiens


Alignment Length:656 Identity:147/656 - (22%)
Similarity:231/656 - (35%) Gaps:202/656 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IGIDLGTTYS-----------CVGV---WQNSKVEIIANDQG--NRTTPSYVAFNETERLIGDPA 55
            :.:|.|||.|           |:.|   |:       ..|.|  |:.||:.:......:.     
Human    76 VAVDFGTTSSGYAYSFTKEPECIHVMRRWE-------GGDPGVSNQKTPTTILLTPERKF----- 128

  Fly    56 KNQVAMNAKNTVFDAKRLIGRKFDDKKIQEDLKLWPFKV-INEKGKPKIEVEFKGER-KRFAPEE 118
             :.....|::...|        .|..:.::.|.|..||: ::..|...::.:..... |:....|
Human   129 -HSFGYAARDFYHD--------LDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALE 184

  Fly   119 ISSMVLTKMREIAEVYL----GGKVKDA----VVTVPAYFNDSQRQATKDAGSIAGL------NV 169
            |.:..|...:|.|...|    |.:.:::    |:||||.:....:|..:.|...|||      ..
Human   185 IFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLASPENSEQ 249

  Fly   170 LRIINEPTAAAL--------------------AYG-------------------------LDKNL 189
            |.|..||.||::                    .|.                         |.:|:
Human   250 LIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTFLVENV 314

  Fly   190 KGE--------RNVLIFDLGGGTFDVSV--LSIDEGSLFEV-KATAGDTHLGGED--FDNRLVNH 241
            .||        ...::.|.||||.|::|  :.:.||.|.|: |||.|.....|.|  |:..|...
Human   315 IGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLLYKI 379

  Fly   242 FAEEFKRKHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFE-- 304
            |.|:|..:.|  ||..| |...|..|.|..||..:......|.|......||:|.|......|  
Human   380 FGEDFIEQFK--IKRPA-AWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHA 441

  Fly   305 --ELNMD-------------------LFRSTMQPVERALSD--AKMDKKAIHDVVLVGGSTRIPK 346
              :.|:|                   ||:.|:..:...|.|  .|.:...:..:.||||....|.
Human   442 LRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAEAPL 506

  Fly   347 IQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVDVAPLSLGIETAGGVM 411
            :|:.:|..| |.|..:.|..|..:   ..::.|:|.|:..:.|:    |..:||:.|:    ||:
Human   507 LQQAVQAAF-GDQCRIIIPQDVGL---TILKGAVLFGLDPAVIK----VRRSPLTYGV----GVL 559

  Fly   412 TNLVE----------RNARIPCKQ------------------QQIFTTYSDNQNAVTIQVYEGER 448
            ...||          ::....|..                  ::.:|....:|..:.|.:|..|.
Human   560 NRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIVINIYSSEH 624

  Fly   449 AMTKDN---------NLLGT--FNLTGIP----PAPRGVPQIEVAFDLNADGILNVNAKDNSTGK 498
                ||         ...||  .:|||..    ||.|.: |..:.|   .|..:...|.|.:|.|
Human   625 ----DNVSFITDPGVKKCGTLRLDLTGTSGTAVPARREI-QTLMQF---GDTEIKATAIDIATSK 681

  Fly   499 SEKITI 504
            |.|:.|
Human   682 SVKVGI 687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-2NP_524339.1 PTZ00009 1..632 CDD:240227 147/656 (22%)
HSPA1-2_6-8-like_NBD 6..382 CDD:212675 110/489 (22%)
HSPA12ANP_001317093.1 HSPA12A_like_NBD 74..540 CDD:212685 111/491 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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