DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-2 and ssa2

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_588421.1	Gene:	ssa2 / 2539225	PomBaseID:	SPCC1739.13	Length:	647	Species:	Schizosaccharomyces pombe

Alignment Length:	645	Identity:	439/645 - (68%)
Similarity:	524/645 - (81%)	Gaps:	19/645 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70
            :|||||||||||||.:.|::|||||||||||||||||||.:|||||||.||||||||..||:|||
pombe     4 SIGIDLGTTYSCVGHFSNNRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTIFDA 68

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            ||||||||||.::|.|:|.||||||::.|||.::||:|||.|.|.|||||||||.||||.||.||
pombe    69 KRLIGRKFDDPEVQSDMKHWPFKVISKDGKPVLQVEYKGETKTFTPEEISSMVLMKMRETAEAYL 133

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 200
            ||||.||||||||||||||||||||||.|||||||||||||||||:|||||::.:||.|||||||
pombe   134 GGKVTDAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDRSNQGESNVLIFDL 198

  Fly   201 GGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLR 265
            ||||||||:|:|:|| :||||||||||||||||||:||||||.:|||||:|.||.|||||:||||
pombe   199 GGGTFDVSLLTIEEG-IFEVKATAGDTHLGGEDFDSRLVNHFIQEFKRKNKKDITGNARAVRRLR 262

  Fly   266 TACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKK 330
            |||||||||||||.:||:|||:|.||||||:.|:|||||||..||||.||:||||.|.|:|:||.
pombe   263 TACERAKRTLSSSAQASIEIDSLFEGIDFYTSITRARFEELCADLFRKTMEPVERVLRDSKVDKA 327

  Fly   331 AIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLV 395
            :::::||||||||||::|||:.|.|.||:...|||||||||||||||||:|||..|.:.|||||:
pombe   328 SVNEIVLVGGSTRIPRVQKLVSDFFNGKEPCKSINPDEAVAYGAAVQAAVLTGDTSEKTQDLLLL 392

  Fly   396 DVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTF 460
            ||||||:||||||||||.|::||..||.|:.:||:||||||..|.|||:|||||.|||.||||.|
pombe   393 DVAPLSMGIETAGGVMTPLIKRNTTIPTKKSEIFSTYSDNQPGVLIQVFEGERARTKDCNLLGKF 457

  Fly   461 NLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAEK 525
            .|:||||||||||||||.||::|:|||||:|.:..|||::||||:||||||||.|||||::||||
pombe   458 ELSGIPPAPRGVPQIEVTFDVDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDRMVAEAEK 522

  Fly   526 YKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEA-SWLDKNSLAEK 589
            ||.||:.:..|:|:||:||:|.|:.|.::||.......:....:..||...|. .|||.|:.|.|
pombe   523 YKAEDEAESGRIQAKNHLESYAYSLRNSLDDPNLKDKVDASDKETVDKAVKETIEWLDSNTTAAK 587

  Fly   590 EEFESHLKECQRICTPIMSKIH------GGKKGK-----------SSMGKGSHPTVEEVD 632
            :|||:..||.:.:..|||:||:      ||..|.           ::.|..:.|.|||||
pombe   588 DEFEAKQKELESVANPIMAKIYQAGGAPGGMPGAAPGAAPGAAPGAAPGGDNGPEVEEVD 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	437/643 (68%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	291/375 (78%)
ssa2	NP_588421.1	PTZ00009	4..647	CDD:240227	437/643 (68%)
ssa2	NP_588421.1	HSPA1-2_6-8-like_NBD	4..379	CDD:212675	291/375 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720