Protein Alignment Hsc70-2 and Hspa1l

DIOPT Version :9

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_997711.1
• Gene: Hspa1l / 24963
• RGDID: 1595925
• Length: 641
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 458/639 - (71%)
• Similarity: 536/639 - (83%)
• Gaps: 17/639 - (2%)

  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70
            |||||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||.:||||||
  Rat     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            ||||||||:|..:|.|:|||||:||||.||||:.|.:|||:|.|.||||||||||||:|.||.:|
  Rat    73 KRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVLVSYKGEKKAFYPEEISSMVLTKMKETAEAFL 137

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 200
            |..|.:||:||||||||||||||||||.|||||||||||||||||:||||||...|||:||||||
  Rat   138 GHSVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLIFDL 202

  Fly   201 GGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLR 265
            ||||||||:|:||:| :||||||||||||||||||||||:||.||||||||.||..|.||:||||
  Rat   203 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 266

  Fly   266 TACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKK 330
            ||||||||||||||:|:||||:|:||||||:.|:|||||||..||||.|::|||::|.||||||.
  Rat   267 TACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMDKA 331

  Fly   331 AIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLV 395
            .|||:|||||||||||:||||||.|.|:.||.|||||||||||||||||||.|..|.::|||||:
  Rat   332 KIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLL 396

  Fly   396 DVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTF 460
            ||||||||:||||||||.|::||:.||.||.||||||||||..|.|||||||||||:||||||.|
  Rat   397 DVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRF 461

  Fly   461 NLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAEK 525
            :||||||||||||||||.||::|:|||||.|.|.||||:.||||:||||||||.||:||:.|||:
  Rat   462 DLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEIERMVQEAER 526

  Fly   526 YKVEDDRQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKNSLAEK 589
            ||.||:.|||::.:||.||:|.:..:.|| |:.....:||:::.|:.||||...|||:.|.||||
  Rat   527 YKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKISESDKKKILDKCSEVLSWLEANQLAEK 591

  Fly   590 EEFESHLKECQRICTPIMSKIH-----------GGKKGKSSMGKGSHPTVEEVD 632
            |||:...||.:.:|.||::|::           |...|:::.|    ||:||||
  Rat   592 EEFDHKRKELENMCNPIITKLYQSGCTGPTCAPGYTPGRAATG----PTIEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	456/637 (72%)
		HSPA1-2_6-8-like_NBD	6..382	CDD:212675	301/375 (80%)
Hspa1l	NP_997711.1	PTZ00009	3..641	CDD:240227	456/637 (72%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		303/380 (80%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		89/114 (78%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830