Protein Alignment Hsc70-2 and HSPA4L

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 199/738 - (26%)
• Similarity: 350/738 - (47%)
• Gaps: 136/738 - (18%)

  Fly     2 GKIPA----------IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAK 56
            |.:||          :|||||.....:.|.::..:|.|||:..:|.||:.::.....|.||:.||
Human    20 GSVPAARPSRGGMSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAK 84

  Fly    57 NQVAMNAKNTVFDAKRLIGRKFDDKKIQEDLKLWPFKVIN-EKGKPKIEVEFKGERKRFAPEEIS 120
            :|:..|.:||:...|:|.||.|||..:|.:....|:::.. ..|...::|.:..|.:.||.|:::
Human    85 SQIVTNVRNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVT 149

  Fly   121 SMVLTKMREIAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGL 185
            .|:|.|::|.:|..|...|.|.|:::|::|.|::|::...|..:||||.||::||.||.|||||:
Human   150 GMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGI 214

  Fly   186 DKN-----LKGERNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEE 245
            .|.     .:..|||:..|:|...:.|.|.:.::|.| :|.||..|.:|||.:||..||::|.:|
Human   215 YKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDE 278

  Fly   246 FKRKHKSDIKGNARALRRLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMD 309
            ||.|:|.::|.|:|||.||...||:.|:.:| ::::..|.|:.....:|..||::||:||:|...
Human   279 FKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCAS 343

  Fly   310 LFRSTMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGA 374
            |......|::..:..|.:.::.|..:.:|||:||||.:::.:...| .|.::.::|.|||||.|.
Human   344 LLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFF-LKDISTTLNADEAVARGC 407

  Fly   375 AVQAAILTGVGSSQIQDLLLVDVAPLSL------GIETAGGVMTNLVERNARIPCKQ-----QQI 428
            |:|.|||:  .:.::::..:.|:.|.|:      ..|...|        ...:.||.     .::
Human   408 ALQCAILS--PAFKVREFSITDLVPYSITLRWKTSFEDGSG--------ECEVFCKNHPAPFSKV 462

  Fly   429 FTTYSDNQNAVTIQVYEGERAMTKDNNL------LGTFNLTGIPPAPRG-VPQIEVAFDLNADGI 486
            .|.:..       :.:|.|...|..:.:      :|:|.:..:.|...| ..:::|...:|..||
Human   463 ITFHKK-------EPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGI 520

  Fly   487 LNVNA----------------------------KDN--------------------------STG 497
            .:|.:                            |||                          .||
Human   521 FSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTG 585

  Fly   498 KSEKITISNDKGRLSKA-------EID--------RMLSE---------AEKYKVEDDRQRERVQ 538
            ...|..:|:.:.||::.       .||        |.|.:         ..|..::|..::||..
Human   586 AKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERND 650

  Fly   539 SKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWLDKNSLAE-KEEFESHLKECQRI 602
            :||.:|.|:|..|..:.......::..:.||:........:||.::...: |:.:...|:|.::.
Human   651 AKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKY 715

  Fly   603 CTPIMSKI--HGGK-KGKSSMGK 622
            ..||..|.  |..: |..:.:||
Human   716 GQPIQMKYMEHEERPKALNDLGK 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	199/738 (27%)
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	138/383 (36%)