DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and Hspa4l

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_035150.3	Gene:	Hspa4l / 18415	MGIID:	107422	Length:	838	Species:	Mus musculus

Alignment Length:	720	Identity:	198/720 - (27%)
Similarity:	349/720 - (48%)	Gaps:	120/720 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            :|||||.....:.|.::..:|.|||:..:|.||:.::.....|.||:.||:|:..|.:||:...|
Mouse     4 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIHGFK 68

  Fly    72 RLIGRKFDDKKIQEDLKLWPFKVIN-EKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            :|.||.|||..:|.:....|:::.. ..|...::|.:..|.:.||.|:::.|:|.|::|.:|..|
Mouse    69 KLHGRSFDDPIVQTERIRLPYELQKMPNGSTGVKVRYLEEERPFAIEQVTGMLLAKLKETSENAL 133

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN-----LKGERNV 195
            ...|.|.|:::|::|.|::|::...|..:||||.||::||.||.|||||:.|.     .:..|||
Mouse   134 KKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEKPRNV 198

  Fly   196 LIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARA 260
            :..|:|...:.|||.:.::|.| :|.||..|.:|||.:||..||::|.:|||.|:|.::|.|:||
Mouse   199 VFIDMGHSAYQVSVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENSRA 262

  Fly   261 LRRLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSD 324
            |.||...||:.|:.:| ::::..|.|:.....:|..||::||:||:|...|......|::..:..
Mouse   263 LLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKSVMDQ 327

  Fly   325 AKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQI 389
            |.:.::.|:.:.:|||:||||.:::.:...| .|.::.::|.|||||.|.|:|.|||:  .:.::
Mouse   328 ANLQREDINSIEIVGGATRIPAVKEQVTRFF-LKDISTTLNADEAVARGCALQCAILS--PAFKV 389

  Fly   390 QDLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQV--------YEG 446
            ::..:.|:.|.|:.:..    .|:..|....  |:      .:|.|..|...:|        :|.
Mouse   390 REFSITDLVPYSVTLRW----KTSFEEGTGE--CE------VFSKNHPAPFSKVITFHKKEPFEL 442

  Fly   447 ERAMTKDNNL------LGTFNLTGIPPAPRG-VPQIEVAFDLNADGILNVNA-----KDNSTG-- 497
            |...|..:.:      :|.|.:..:.|...| ..:::|...:|..||.:|.:     |.|..|
Mouse   443 EAFYTNLHEVPYPDPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDH 507

  Fly   498 ----------KSE------KITISNDKGRLSKA--------EIDRMLSEAE-------------- 524
                      |||      |:.:..::|...|.        |||...::|:
Mouse   508 NDAAMETEAPKSEGKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAPPSDKQDRINQTI 572

  Fly   525 ---------------------------------KYKVEDDRQRERVQSKNNLEAYIYACRQAVDD 556
                                             |..::|..::||..:||.:|.|:|..|..:..
Mouse   573 KKGKIKSIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKLGT 637

  Fly   557 APSGVLSETERSKVRDKCSSEASWL-DKNSLAEKEEFESHLKECQRICTPIMSKI--HGGK-KGK 617
            .....::..:.:|:........:|| ::.....|:.:...|:|.::...||..|.  |..: |..
Mouse   638 VYEKFITPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDRLQELKKYGQPIQMKYVEHEERPKAL 702

  Fly   618 SSMGK 622
            :.:||
Mouse   703 NDLGK 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	198/720 (28%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	139/381 (36%)
Hspa4l	NP_035150.3	HSPA4L_NBD	2..384	CDD:212688	139/381 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..566		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910