Protein Alignment Hsc70-2 and hsp-110

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_498868.1
• Gene: hsp-110 / 176195
• WormBaseID: WBGene00016250
• Length: 776
• Species: Caenorhabditis elegans
• Alignment Length: 675
• Identity: 196/675 - (29%)
• Similarity: 320/675 - (47%)
• Gaps: 103/675 - (15%)

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            :|.|:|.....:||.:...:|:|.||.....||:.|:|...:|.:|..|:..|..|.||||.:.|
 Worm     4 LGFDIGNLNCYIGVARQGGIEVITNDYSLHATPACVSFGPKDRSMGVAARQAVTTNIKNTVINFK 68

  Fly    72 RLIGRKFDDKKIQEDLKLWPFKVI----NEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAE 132
            .||||||.|...|..:...|.||:    ::.|   ::|.:.||...|.||::.:.:|||:|.|.|
 Worm    69 HLIGRKFSDPVAQRFIPFIPCKVVKLPNDDIG---VQVSYLGEPHTFTPEQVLAALLTKLRTIVE 130

  Fly   133 VYLGG--KVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDK-NLKGE-- 192
            ..|..  ||.|.|:.||:||.|.||:|...|...||||.|||:||.||.|||||:.| :|..|
 Worm   131 SQLSDVKKVSDCVLAVPSYFTDVQRRAVLSAIQYAGLNSLRIVNETTAIALAYGIYKQDLPEEDA 195

  Fly   193 --RNVLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIK 255
              |||:..|:|..:...|:::.:.|.| ::..|:.|...||..||..:..||.:|||.|:..|..
 Worm   196 KSRNVVFLDIGHSSTQASLVAFNRGKL-QMVNTSYDLESGGIWFDALIREHFRKEFKTKYGIDAA 259

  Fly   256 GNARALRRLRTACERAKRTLSSS-TEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVE 319
            .:.|...||...|||.|:.:|:: |...|.|:...|..|...|:.|..||:|...:|....|.:.
 Worm   260 TSPRPWLRLLDECERVKKQMSANQTPIPLNIECFMEDKDVTGKMQRQEFEDLAAPIFNRIKQVLI 324

  Fly   320 RALSD-AKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTG 383
            ...:| ..:..:.|.::.:||||:|||.|:::::||| ||:...::|.|||||.|||:|.|||:
 Worm   325 NLFADGVSIKPEEIDEIEIVGGSSRIPMIREIVKDLF-GKEPKTTMNQDEAVARGAAMQCAILS- 387

  Fly   384 VGSSQIQDLLLVDVAPLSLGI------ETAGGVMTNLVERNARIPCKQQQIFTTYSD-------- 434
             .:.::::..:.|..|..:.:      |..|                :..:|:...:
 Worm   388 -PTFRVREFAIKDTQPYRIRLSWNSTGENGG----------------ENDVFSPRDEVPFSKLVS 435

  Fly   435 --NQNAVTIQVYEGERAMTKDNNL-LGTFNLTGI-PPAPRGVPQIEVAFDLNADGILNV------ 489
              ......::.:..:..:...|.: :|::.:.|. |.|..|..:::|...:|.|||..:
 Worm   436 LLRSGPFNVEAHYAQPNVVPHNQVHIGSWKVNGARPGADGGNQKVKVKVRVNPDGIFTIASATMY 500

  Fly   490 -----------------NAKDNSTGKS-----------------EKITISNDKGRLSKAEIDRML 520
                             :||..:..:.                 |.|.:|.|..:....|:....
 Worm   501 EPRIVEEVPAEAMEVDGDAKTEAPAEPLEPVKKTKLVPVDLEVIESIPVSYDVQKFHNLELQMQE 565

  Fly   521 SEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWL-DKN 584
            |:|        |::.:..:||:||.|:|..|..|.|..:..::.....:.|...:|...|| |:.
 Worm   566 SDA--------REKAKADAKNSLEEYVYEMRDKVSDQYAEFITPAAADEFRSVLTSTEDWLYDEG 622

  Fly   585 SLAEKEEFESHLKECQRICTPIMSK 609
            ..||::.:|..|.|.:.:.||::.:
 Worm   623 EDAERDVYEKRLSELKAVGTPVVER 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	196/675 (29%)
hsp-110	NP_498868.1	HSP70	3..650	CDD:394970	196/675 (29%)