DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and T24H7.2

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_495249.1	Gene:	T24H7.2 / 174033	WormBaseID:	WBGene00020781	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	757	Identity:	174/757 - (22%)
Similarity:	328/757 - (43%)	Gaps:	158/757 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKIPAIGIDLGTTYSCVGVWQ-NSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKN 65
            |::.|:.|||||.:..:|:.: ...::|..|.:..|.||:.|...:..|...|.|   :.|..:.
Worm    22 GQLAAMTIDLGTQFLKIGIVKPGIPMDIALNTESRRKTPNVVMIQDGHRTFADAA---IGMQVRY 83

  Fly    66 TVF---DAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKM 127
            ...   ....|:|:.......:...:...|..:::..|....:.||...:.:..|.:::|:|...
Worm    84 PHLVHGQLNDLVGKSTQHPSFELFKRRNTFFEVDDAPKNASSINFKLGGESYTVEALTAMILANA 148

  Fly   128 REIAEVYL-GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLK- 190
            ::..|.|. ..::||.|:|||.||..::|.|.:.|..:|||.||::||:.|||||::|:.:..:
Worm   149 KKFTEEYAQAAEIKDVVITVPVYFTPAERLAVERAAQMAGLTVLQLINDGTAAALSHGIFRRKEI 213

  Fly   191 GER--NVLIFDLGGGTFDVSVLSI-------DEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEF 246
            ||:  .::::|:|......:::..       ::.....|.....|..|||.:..|||.:|..|.|
Worm   214 GEKPQRLMVYDMGAAKTTATIVEFKLVKEKYEKQPKMTVLGVGFDRTLGGIEMTNRLRDHLIEMF 278

  Fly   247 KR--KHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMD 309
            ::  |.|:.:..|.||:.:.....||.|:.||::.|...:|::.||.||...|::|..|..|..|
Worm   279 EKNYKPKTKVNTNRRAMTKFSKEAERLKQVLSANAEHFAQIESAHEDIDAKLKVTREDFNHLISD 343

  Fly   310 LFRSTMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGA 374
            :.....:|:|:||..|::....|...||:|..||:||:|:::|...|.|::...:|.|||||.||
Worm   344 MESRFGEPIEQALRMAQIPIDDIDQFVLMGAGTRVPKVQEIVQKTIGTKEIGKFLNTDEAVAMGA 408

  Fly   375 AVQAAILT---GVGSSQIQDLLLVDVAPLSLGI----------ETAG--GVMTNLVERNARIPCK 424
            ..|||.|:   .|....|::.:   :.|:.:..          |..|  .|:..|...|:..|..
Worm   409 LFQAAHLSKGFKVKPFNIEEKV---IFPVEVHFVSKIRDEKTEEITGEKNVVKTLFAANSVYPTH 470

  Fly   425 QQQI-FTTYSDNQNAVTIQVYEGERAMTKD---------NNLLGTFNLTGIPPAPRG-------V 472
            .:.| .|:|||: .:|.:: |....:.||.         :||:.. .::|:..|.:.       .
Worm   471 PKTISLTSYSDD-FSVALK-YGKIESFTKQQVQEIGSLLDNLVDV-EISGLSEALKNRSSEESEF 532

  Fly   473 PQIEVAFDLNADGILNVN---------------------------------AKDNSTGKS----- 499
            ..::|:|.::|.||:.|.                                 ..|:||.:|
Worm   533 KGVKVSFIVDASGIVRVRRAEALFEPKSGLVGSIASTISGLFSSKTEEGEPTTDDSTPQSTEEKT 597

  Fly   500 -EKITI------------------SNDKGRLSKAEIDRMLSEA---------------------- 523
             ||.::                  |.:..:.::.|.:.....|
Worm   598 EEKESVKVEDSTPEPEPETPVNSTSEESPKTNETEKNASSGNATEVKEKKKELPSIVRLRITNKY 662

  Fly   524 ------EKYKVEDDRQR------------ERVQSKNNLEAYIYACRQAVDDAP-SGVLSETERSK 569
                  .||.|:::::|            ||...:|.||::.:.|.|.:::.. :..:::.|::|
Worm   663 PSAFVPNKYDVQEEKRRMEAFAEKERLASERAAVENELESFNFECSQYLEETEFTDYMADEEKTK 727

  Fly   570 VRDKCSSEASWLDKNSLAE--KEEFESHLKECQRICTPIMSK 609
            :.|......:||:.:...:  .::|..:|.|.:.:...:..:
Worm   728 LEDSVKRIRAWLEDDVTKDTPTKDFTDNLLELKNVVRSVKKR 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	174/757 (23%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	116/392 (30%)
T24H7.2	NP_495249.1	HYOU1-like_NBD	27..413	CDD:212672	113/388 (29%)
T24H7.2	NP_495249.1	DnaK	29..669	CDD:223520	153/648 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810