DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-2 and Hspa9

DIOPT Version :10

Sequence 1:NP_524339.1 Gene:Hsc70-2 / 41609 FlyBaseID:FBgn0001217 Length:633 Species:Drosophila melanogaster
Sequence 2:NP_034611.2 Gene:Hspa9 / 15526 MGIID:96245 Length:679 Species:Mus musculus


Alignment Length:625 Identity:296/625 - (47%)
Similarity:404/625 - (64%) Gaps:65/625 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFN-ETERLIGDPAKNQVAMNAKNTVFDA 70
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||. :.|||:|.|||.|...|..||.:..
Mouse    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVIN-EKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVY 134
            ||||||::||.::|:|.|..|||::. ..|...:|    ...|.::|.:|.:.||.||:|.||.|
Mouse   121 KRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVE----AHGKLYSPSQIGAFVLMKMKETAENY 181

  Fly   135 LGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 199
            ||...|:||:||||||||||||||||||.|:||||||:|||||||||||||||:  .::.:.::|
Mouse   182 LGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVYD 244

  Fly   200 LGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRL 264
            |||||||:|:|.|.:| :||||:|.|||.|||||||..|:.|..:||||:...|:..:..||:|:
Mouse   245 LGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRV 308

  Fly   265 RTACERAKRTLSSSTEASLEIDAL--------HEGIDFYSKISRARFEELNMDLFRSTMQPVERA 321
            |.|.|:||..||||.:..:.:..|        |..:    |::||:||.:..||.:.|:.|.::|
Mouse   309 REAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNM----KLTRAQFEGIVTDLIKRTIAPCQKA 369

  Fly   322 LSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGS 386
            :.||::.|..|.:|:||||.||:||:|:.:|||| |:..:.::|||||||.|||:|..:|.|   
Mouse   370 MQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAG--- 430

  Fly   387 SQIQDLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMT 451
             .:.|:||:||.||||||||.|||.|.|:.||..||.|:.|:|:|.:|.|..|.|:|.:|||.|.
Mouse   431 -DVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMA 494

  Fly   452 KDNNLLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEI 516
            .||.|||.|.|.||||||||||||||.||::|:||::|:|||..||:.::|.|.: .|.|||.:|
Mouse   495 GDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDI 558

  Fly   517 DRMLSEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWL 581
            :.|:..||||..||.|::|||::.|..|               |::.:||               
Mouse   559 ENMVKNAEKYAEEDRRKKERVEAVNMAE---------------GIIHDTE--------------- 593

  Fly   582 DKNSLAEKEEFESHL--KECQRICTPIMSKIHGGKKGKSS 619
                 .:.|||:..|  .||.::...| ||:.....||.|
Mouse   594 -----TKMEEFKDQLPADECNKLKEEI-SKMRALLAGKDS 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-2NP_524339.1 PTZ00009 1..632 CDD:240227 296/625 (47%)
Hspa9NP_034611.2 Interaction with NFS1. /evidence=ECO:0000250|UniProtKB:P38646 1..432 194/391 (50%)
dnaK 52..673 CDD:234715 296/625 (47%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P38646 63..431 188/383 (49%)
Interaction with FXN and ISCU. /evidence=ECO:0000250|UniProtKB:P38646 432..679 102/233 (44%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:P38646 432..441 4/8 (50%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P38646 442..679 97/223 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..679
Blue background indicates that the domain is not in the aligned region.

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