DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and Hspa4

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_032326.3	Gene:	Hspa4 / 15525	MGIID:	1342292	Length:	842	Species:	Mus musculus

Alignment Length:	695	Identity:	204/695 - (29%)
Similarity:	339/695 - (48%)	Gaps:	100/695 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71
            :|||||.....|.|.:...:|.|||:..:|.||:.|:|....|.||..||:||..||||||...|
Mouse     4 VGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSIGAAAKSQVISNAKNTVQGFK 68

  Fly    72 RLIGRKFDDKKIQEDLKLWPFKVIN-EKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135
            |..||.|.|..::.:.....:.::. ..|...|:|.:..|.:.|..|::::|:|:|::|.||..|
Mouse    69 RFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVL 133

  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN-----LKGERNV 195
            ...|.|.||:||:::.|::|::..||..|||||.||::||.||.|||||:.|.     .:..|||
Mouse   134 KKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNV 198

  Fly   196 LIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARA 260
            :..|:|...:.|||.:.::|.| :|.|||.||.|||..||..|||||.|||.:|:|.|||...||
Mouse   199 VFVDMGHSAYQVSVCAFNKGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKIRA 262

  Fly   261 LRRLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSD 324
            |.||...||:.|:.:| ::::..|.|:.....||....::|.:|.|:..||......|:...|..
Mouse   263 LLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSVLEQ 327

  Fly   325 AKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQI 389
            :|:.|:.|:.|.:|||:||||.:::.:...| ||:|:.::|.||||..|.|:|.|||:  .:.::
Mouse   328 SKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PAFKV 389

  Fly   390 QDLLLVDVAPLSLGIETAGGVMTNLVE-----RNARIPCKQQQIFTTYSDNQNAVTIQV-YEGER 448
            ::..:.||.|..:.:.........|.:     :|...|.  .::.|.|  .:...|::. |...:
Mouse   390 REFSITDVVPYPISLRWNSPAEEGLSDCEVFPKNHAAPF--SKVLTFY--RKEPFTLEAYYSSPQ 450

  Fly   449 AMTKDNNLLGTFNLTGIPPAPRG-VPQIEVAFDLNADGILNVNA-----------------KDNS 495
            .:...:..:..|::..:.|...| ..:::|...:|..||.:|::                 .|.:
Mouse   451 DLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQN 515

  Fly   496 TGKSEKITISNDKGRL------------SKAEIDRMLS--------------EAEKYKV------ 528
            ..:.||:.:..::...            :|||.:.|.:              :|:|.||
Mouse   516 AKEEEKMQVDQEEPHTEEQQQQPQTPAENKAESEEMETSQAGSKDKKTDQPPQAKKAKVKTSTVD 580

  Fly   529 ----------------------------EDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSET 565
                                        :|..::||..:||.:|.|:|..|..:.......:||.
Mouse   581 LPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSED 645

  Fly   566 ERSKVRDKCSSEASWLDKNSLAE-KEEFESHLKECQRICTPIMSK 609
            :|:....|.....:||.::...: |:.:...|.|.:.:..||.::
Mouse   646 DRNTFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKSLGQPIKTR 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	204/695 (29%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	154/381 (40%)
Hspa4	NP_032326.3	HSPA4_NBD	2..384	CDD:212687	154/381 (40%)
		HSP70	3..609	CDD:278441	184/612 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..577		11/76 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810